In Silico Optimization of a Streptomyces sp. Antimicrobial Peptide Against Oncobacteria in Oral Squamous Cell Carcinoma DOI Open Access
Zarin Taj,

Vannamathi Marisamy,

Indranil Chattopadhyay

et al.

Peptide Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

ABSTRACT Oral squamous cell carcinoma (OSCC) is a major public health concern, accounting for more than 90% of all oral malignancies. Pathogenic bacteria, such as Streptococcus mutans , Fusobacterium nucleatum and Porphyromonas gingivalis are closely linked to OSCC promote chronic inflammation, key factor in the tumor microenvironment. The increasing incidence malignancies necessitates development antimicrobial peptides (AMPs) with enhanced anticancer activity targeted therapeutics against bacteria mitigate their impact on OSCC. A total 182 Streptomyces genus‐derived AMPs were collected analyzed silico determine potent antibacterial characteristics. Fourteen tested 3D structural alignment prediction validation, most efficient peptide was determined be sAMP2. genome‐based analysis sourced from globisporus C‐1027 conducted explore its evolutionary significance. cell‐penetrating sAMP2 optimized make it stable better able target host cellular receptors. Mut_sAMP2 found interact bacterial virulence proteins DEX S. LPS F. KGP P. OSCC‐associated (TNFα, IL‐6, IL‐8, p38, p53, E‐cadherin, Jak‐1, PAR2) greater binding affinity. treated OECM‐1 cells showed reduced survival by cytotoxicity IC50 5.4 μg/mL. To best our knowledge, computational study first significantly new effective cancer sp. derived broad spectrum potential evaluating combat progression oncobacteria.

Language: Английский

Exploring the anti-colon cancer potential of febuxostat-based mixed metal complexes with 2,2′-bipyridine: MTT assay, toxicity evaluation, prediction profiles, and computational studies DOI
Leila M. Abbass, Mustapha Belaidi, Saleh M. Bufarwa

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114460 - 114460

Published: April 1, 2025

Language: Английский

Citations

0
Targeting Microbial Biofilms and Promoting Wound Healing in MRSA-Infected Diabetic Rats using Postbiotics of Lactiplantibacillus plantarum DOI

A Narang,

Kirandeep Kaur, Neena Bedi

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

0
Antimicrobial Peptide-Coated Molybdenum Disulfide Nanoparticles for Enhanced Antimicrobial Effect and Biofilm Eradication DOI
Jianping Yang, Runze Yang, Jiale Sun

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
In Silico Optimization of a Streptomyces sp. Antimicrobial Peptide Against Oncobacteria in Oral Squamous Cell Carcinoma DOI Open Access
Zarin Taj,

Vannamathi Marisamy,

Indranil Chattopadhyay

et al.

Peptide Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

ABSTRACT Oral squamous cell carcinoma (OSCC) is a major public health concern, accounting for more than 90% of all oral malignancies. Pathogenic bacteria, such as Streptococcus mutans , Fusobacterium nucleatum and Porphyromonas gingivalis are closely linked to OSCC promote chronic inflammation, key factor in the tumor microenvironment. The increasing incidence malignancies necessitates development antimicrobial peptides (AMPs) with enhanced anticancer activity targeted therapeutics against bacteria mitigate their impact on OSCC. A total 182 Streptomyces genus‐derived AMPs were collected analyzed silico determine potent antibacterial characteristics. Fourteen tested 3D structural alignment prediction validation, most efficient peptide was determined be sAMP2. genome‐based analysis sourced from globisporus C‐1027 conducted explore its evolutionary significance. cell‐penetrating sAMP2 optimized make it stable better able target host cellular receptors. Mut_sAMP2 found interact bacterial virulence proteins DEX S. LPS F. KGP P. OSCC‐associated (TNFα, IL‐6, IL‐8, p38, p53, E‐cadherin, Jak‐1, PAR2) greater binding affinity. treated OECM‐1 cells showed reduced survival by cytotoxicity IC50 5.4 μg/mL. To best our knowledge, computational study first significantly new effective cancer sp. derived broad spectrum potential evaluating combat progression oncobacteria.

Language: Английский

Citations

0