Applied and Environmental Microbiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Antimicrobial resistance (AMR) has emerged as a significant crisis in global health. Due to their advantageous properties, antimicrobial peptides (AMPs) have garnered considerable attention potential alternative therapy address the AMR crisis. These might disrupt cell membranes or walls exhibit activity, modulate immune response promote recovery from diseases. In recent years, progress been made research of AMPs, alongside emergence new challenges. This review first systematically summarizes and critically discusses advancements understanding characteristics current landscapes well regulatory mechanisms action practical applications, particularly those reported approved within last 5 years. Additionally, principles, paths for identification, future trends AMPs are also analyzed following discussion advantages disadvantages comparison conventional antibiotics. Unlike prior literature this field, report summarized latest major discovery methods and, more importantly, emphasized applications by supporting various viewpoints using selected examples AMPs' real-life scenarios. Besides, some emerging hot topics including derived gut microbiota synergistic effects combating AMR, were profiled. All these indicate originality provide valuable references AMP discoveries applications.
Language: Английский