Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis DOI Creative Commons
Rebecca L. Ross, Georgia Mavria, Francesco Del Galdo

et al.

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: May 5, 2022

Systemic sclerosis (SSc) is a terminal disease characterized by vasculopathy, tissue fibrosis, and autoimmunity. Although the exact etiology of SSc remains unknown, endothelial dysfunction, oxidative stress, calcium handling dysregulation have been associated with large number SSc-related complications such as neointima formation, vasculogenesis, pulmonary arterial hypertension, impaired angiogenesis, cardiac arrhythmias. Hemeoxygenase-1 (HO-1) an antioxidant enzyme involved in multiple biological actions cardiovascular system including vascular tone, cellular proliferation, apoptosis, stress. The aim this work was to investigate physiological role HO-1 its relevance occurring SSc. We found that, early phases SSc, expression dermal fibroblast lower compared those isolated from healthy control individuals. This particularly relevant reduction HO-1/CO signaling pathway dysfunction vasculopathy. show evidence HO-1/carbon monoxide (CO) handling. Using vitro model hypertension (PAH) we investigated Ca2+ mobilization intracellular stores. Our results indicate that regulates release stores human cells. interrogated activity angiogenesis using organotypic co-culture fibroblast-endothelial cell. Inhibition significantly reduced ability cells form tubules. further if could be cell motility or migration into extracellular matrix synthesized fibroblasts. By mean holographic imaging, studied morphological functional features presence activator selective inhibitors. demonstrate inhibition reduces proliferation (migration) cultured cells, whilst activation does not modify either morphology, motility. In addition, CO on Kv7.1 (KCQN1) channel current, important component action potential repolarization. electrophysiology (whole-cell patch-clamp recombinant overexpressing KCQN1 channel), assessed regulation CO. CORM-2, donor, suggesting may play modulation via ion channel. summary, our clear link between: 1) downregulation signaling; 2) pathophysiological processes homeostasis dysregulation, A better understanding canonical (mainly due CO), non-canonical HO-1, well interaction other gasotransmitters will contribute development novel therapeutic approaches.

Language: Английский

Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy DOI Creative Commons

Yuan-Hua Wu,

Rong-Jane Chen, Hui‐Wen Chiu

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 40 - 58

Published: Nov. 29, 2022

Immunotherapies are now emerging as an efficient anticancer therapeutic strategy. Cancer immunotherapy utilizes the host's immune system to fight against cancer cells and has gained increasing interest due its durable efficacy low toxicity compared traditional antitumor treatments, such chemotherapy radiotherapy (RT). Although combination of RT drawn extensive attention in clinical setting, overall response rates still low. Therefore, strategies for further improvement urgently needed. Nanotechnology been used target not only but also tumor microenvironment (TME), thereby helping generate a long-term response. Nanomaterials can be effective delivery strong autophagy inducer, with ability elevate very high levels. Interestingly, could play critical role optimal function, mediating cell-extrinsic homeostatic effects through regulation danger signaling neoplastic under immunogenic and/or RT. In this review, we summarize preclinical development therapy highlight latest progress nanotechnology augmenting The underlying mechanisms nanomaterial-triggered TME discussed depth. Finally, suggest implications these three combined together achieve goal maximizing advantages show recent advances biomarkers evaluation those therapies.

Language: Английский

Citations

19
Recent advances in the role of gasotransmitters in necroptosis DOI Creative Commons
Marlene M. Hao, Kai Li,

Hang-Shen Han

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0
Acetate and propionate vs. iTBS as a novel method for cognitive dysfunction and anxiety symptoms in delayed encephalopathy after acute carbon monoxide poisoning rat DOI Creative Commons

Tianyu Meng,

Xin Zhang, Jili Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

The optimal treatment methods for delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) were not identified. Thus, this study was conducted to compare the efficacies of intermittent theta burst stimulation (iTBS) and short-chain fatty acids (SCFAs) in treating cognitive dysfunction anxiety symptoms DEACMP rat. In phase I, a rat model built assess inflammation levels hippocampus SCFAs serum rats. II, rats randomly assigned into four groups: + placebo, SCFAs, sham iTBS, iTBS. intervention continued 2 weeks. A Morris water maze open field tests used function symptoms, respectively. three inflammatory factors (IL-1β, IL-6, TNF-α) two (acetate propionate) significantly increased decreased, respectively, After treatment, improved iTBS group (consisting acetate group. Both could improve IL-1β, TNF-α hippocampus, also decreased GPR41, GPR43, dopamine, norepinephrine These results indicate that both SCFA solutions consisting propionate produced good effects on by regulating acetate/propionate-GPR41/GPR43-IL-1β/IL-6/TNF-α-dopamine/norepinephrine may be potential pathway DEACMP.

Language: Английский

Citations

0
HBCOC attenuates cerebral ischemia-reperfusion injury in mice by inhibiting the inflammatory response and autophagy via TREM-1/ERK/NF-κB DOI Creative Commons

R. Li,

Qin Li, Cheng Yang

et al.

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108280 - 108280

Published: March 1, 2025

Hemoglobin-based carbon monoxide carrier (HBCOC) can dissociate and ameliorate organ damage by inhibiting inflammation oxidative stress. In this study, we evaluated its effect on cerebral ischemia-reperfusion injury in mice explored potential mechanism. A middle artery occlusion/reperfusion (MCAO/R) mouse model was established using the wire embolization method, HBCOC or equivalent normal saline administered via tail vein during reperfusion. HE staining TEM were used to observe tissue. The levels of IL-1β, IL-6, TNF-α detected ELISA RT-qPCR, meantime, western blotting detect expressions TREM-1, ERK, NF-κB,LC3 P62. We found that treatment alleviated nerve reduced infarction area caused ischemia-reperfusion, simultaneously lowered expression plasma brain tissues. suppressed LC3II, lysosomes, autophagy brain, suggesting potent inhibition autophagy. Mechanistic analysis indicated TREM-1/ERK/NF-κB pathway-related proteins mRNA higher group than group. combined with targeting TREM-1 receptor inhibitors LP17 inhibited protein, further reducing release inflammatory factors autophagy, restoring function infarct after reperfusion, exerting an overall protective against reperfusion injury. summary, our results TREM-1.

Language: Английский

Citations

0
Stable liposomal cerasome for ultrasound/H2O2-activated CO release to augment tumor chemotherapy and immunotherapy DOI

Suhui Sun,

Ruiqi Wu,

S. Sha

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161398 - 161398

Published: March 1, 2025

Language: Английский

Citations

0
Predictors of delayed encephalopathy after acute carbon monoxide poisoning: a literature review DOI Creative Commons

Yongjing Wang,

Zunzhen Zhou,

Dailiang Zhang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is one of the severe complications that can occur (ACOP). The pathogenesis DEACMP complex, featuring a delitescence onset and poor prognosis. As result, many scholars are concentrating on identifying predictors evaluating their effects, including clinical characteristics, laboratory indicators, neuroelectrophysiology, imaging examination, genetic susceptibility. However, current identified lack consensus application limited. Therefore, we need to explore new predictors. Exosomes, smallest extracellular vesicles (EVs) with nano-size, participate in both physiological pathological processes brain, changes content provide valuable information for diagnosis evaluation neurodegenerative diseases, suggesting they may serve as potential biomarker. practicability exosomes biomarkers remains unclear. In present review, first introduced currently Then, also discussed possibility DEACMP, aiming stimulate more attention discussion this topic, thereby providing meaningful insights future research.

Language: Английский

Citations

0
Urban air pollutant mapping and tracing using multi-points in situ measurements combined with clustering and trajectory analysis DOI
Muhammad Rizky Mulyana, Yosi Aristiawan,

Chairil Linggabinangkit

et al.

Environmental Monitoring and Assessment, Journal Year: 2025, Volume and Issue: 197(4)

Published: March 26, 2025

Language: Английский

Citations

0
Cardiovascular biomarkers: exploring troponin and BNP applications in conditions related to carbon monoxide exposure DOI Creative Commons
Andia Taghdiri

The Egyptian Heart Journal, Journal Year: 2024, Volume and Issue: 76(1)

Published: Jan. 29, 2024

Abstract Background The diagnosis and prognosis of cardiovascular disorders are greatly aided by biomarkers. uses troponin B-type natriuretic peptide in situations involving carbon monoxide exposure examined this narrative review. These biomarkers important because they help predict outcomes disorders, track the effectiveness therapy, influence therapeutic choices. Main body Clinical practice makes considerable use (BNP), which has diuretic vasodilatory effects, troponin, a particular marker for myocardial injury. Carbon (CO) poisoning is major worldwide health problem CO, “silent killer,” significant clinical consequences. Higher risk cardiac problems, poorer outcomes, greater severity all linked to elevated levels. BNP’s adaptability diagnosing dysfunction directing decisions hyperbaric oxygen therapy complemented troponin’s specificity identifying CO-induced damage. When combined, improve accuracy diagnoses offer thorough understanding pathophysiology. Conclusions To sum up, review emphasizes importance (BNP) as indicators during exposure. While BNP predicts long-term better at short-term morbidity death prediction. highly sensitive I (hsTnI) diagnostic patients improved. One difficulties evaluating biomarker levels since symptoms not always clear-cut. Accurate treatment depend on investigation new standardized criteria. results advance intricate field

Language: Английский

Citations

3
Simultaneous Detection of CO and NO2 Gases using Interaction Analysis of SnS2 Sensor Array Response DOI Creative Commons
Srinivasulu Kanaparthi, Shiv Govind Singh

ECS Sensors Plus, Journal Year: 2023, Volume and Issue: 2(4), P. 045201 - 045201

Published: Nov. 16, 2023

Developing a multi-analyte gas sensing system that simultaneously detects trace levels of CO and NO 2 at low temperatures is necessary for the Internet Things (IoT) based air quality monitoring applications. Nevertheless, sensors operating are nonspecific rarely detect target gases lower ppb in air. Herein, an array two SnS with different bias voltages has been developed characterized upon exposure to individual binary mixtures concentrations. The achieved detection limit 45 150 CO. Further, co-adsorption-induced interaction analysis was carried out predict concentration mixture using mixed response. mean absolute percentage error 7.86% observed predicting concentrations mixture, which indicates high prediction accuracy proposed method. As minimal resource intensive approach, method can be used applications require low-power low-cost sensors.

Language: Английский

Citations

6
Enhanced efficiency and selectivity of carbon monoxide absorption by cuprous-based bimetallic deep eutectic solvents via iron activation DOI

Wen-Qiang Gong,

Zhang-Min Li,

Xue-Rui Zhou

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 357, P. 130079 - 130079

Published: Oct. 11, 2024

Language: Английский

Citations

2