Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio)

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137515 - 137515

Published: Feb. 6, 2025

Language: Английский

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An Overview of Current New Approach Methodologies for Developmental Toxicity and the Current Research Gaps

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Advances in genomic toxicology: In vitro developmental toxicity test based on signal network disruption dynamics

Current Opinion in Toxicology, Journal Year: 2024, Volume and Issue: 39, P. 100489 - 100489

Published: July 14, 2024

Developmental toxicity outcomes in humans and animals often exhibit variability; hence, the demand for predictive non-animal alternatives, particularly human cell-based models, are increasing. Despite advancements genomic toxicology, which have facilitated identification of mechanisms potential biomarkers, existing transcriptome analysis-based methods yet to yield highly vitro developmental assays. One possible reason is that assays at a single time point could not capture entire dynamic signal network during processes. This article addresses challenges comprehensive gene expression analysis introduces novel focused on time-dependent dynamics signaling pathway responses crucial development.

Language: Английский

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Standardization and optimization of the hiPSC-based PluriLum assay for detection of embryonic and developmental toxicants

Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Language: Английский

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