Organellar quality control crosstalk in aging‐related disease: Innovation to pave the way DOI Creative Commons
Yu Li, Jinxin Qi,

Lina Guo

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 12, 2024

Abstract Organellar homeostasis and crosstalks within a cell have emerged as essential regulatory determining factors for the survival functions of cells. In response to various stimuli, cells can activate organellar quality control systems (QCS) maintain homeostasis. Numerous studies demonstrated that dysfunction QCS lead aging‐related diseases such neurodegenerative, pulmonary, cardiometabolic cancers. However, interplay between their potential role in these are poorly understood. this review, we present an overview current findings crosstalk, encompassing mitochondria, endoplasmic reticulum, Golgi apparatus, ribosomes, peroxisomes, lipid droplets, lysosomes well aberrant interplays among organelles contributes onset progression disorders. Furthermore, therapeutic approaches based on interactions discussed. Our perspectives enhance insights into networks underlying pathology aging diseases, which may pave way development novel targets.

Language: Английский

Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating? DOI

Kexin Tan,

Xiao‐Ai Zhang,

Jian‐Yuan Yang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 291 - 339

Published: March 13, 2025

Language: Английский

Citations

0
Nano‐Biointeractions of Functional Nanomaterials: The Emerging Role of Inter‐Organelle Contact Sites, Targeting, and Signaling DOI Creative Commons
Naym Blal, Giuseppe Bardi, Pier Paolo Pompa

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 29, 2024

Abstract The study of nano‐biointeractions, at the forefront interdisciplinary research, unveils intricate interplays between nanomaterials (NMs) and intracellular organelles, which are pivotal hubs orchestrating diverse cellular processes. Thanks also to formation dynamic contacts among their membranes, organelles regulate lipid exchange, calcium signaling, metabolic pathways. Recently, potential role NMs in homeostasis through regulation organelle membrane contact sites (MCSs) is emerging, a complete overview this issue still lacking. This perspective aims elucidating synergy functional site underscoring advancing comprehension cell biology mechanisms fostering therapeutic breakthroughs. subject represents crucial aspect as it can reveal new molecular targets for potentially revolutionize strategies. Nanotechnology may offer unprecedented tools decipher manipulate interfaces with remarkable precision. Engineered serve versatile probes effectors, enabling targeted modulation unraveling intricacies governing dynamics. Furthermore, nano‐biointeraction‐driven insights hold promise innovations, offering novel avenues diseases linked dysregulated contacts.

Language: Английский

Citations

1
Organellar quality control crosstalk in aging‐related disease: Innovation to pave the way DOI Creative Commons
Yu Li, Jinxin Qi,

Lina Guo

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 12, 2024

Abstract Organellar homeostasis and crosstalks within a cell have emerged as essential regulatory determining factors for the survival functions of cells. In response to various stimuli, cells can activate organellar quality control systems (QCS) maintain homeostasis. Numerous studies demonstrated that dysfunction QCS lead aging‐related diseases such neurodegenerative, pulmonary, cardiometabolic cancers. However, interplay between their potential role in these are poorly understood. this review, we present an overview current findings crosstalk, encompassing mitochondria, endoplasmic reticulum, Golgi apparatus, ribosomes, peroxisomes, lipid droplets, lysosomes well aberrant interplays among organelles contributes onset progression disorders. Furthermore, therapeutic approaches based on interactions discussed. Our perspectives enhance insights into networks underlying pathology aging diseases, which may pave way development novel targets.

Language: Английский

Citations

1