Jatropha Diterpenes: An Updated Review Concerning Their Structural Diversity, Therapeutic Performance, and Future Pharmaceutical Applications DOI Creative Commons
Thalisson Amorim de Souza, Leila Maria Moreira Beltrão Pereira, Alan Ferreira Alves

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1399 - 1399

Published: Oct. 19, 2024

The

Language: Английский

Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products DOI Creative Commons
Dongyang Li, Xingguo Lan,

Linyi Xu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences efficacy have been observed clinical practice. There is increasing evidence that gut microbial metabolites influence distal via gut-liver axis, gut-brain axis and gut-breast a process may involve modulating expression immune cells cytokines microenvironment (TME). this review, we systematically explore relationship between immunotherapy, examine corresponding natural products their mechanisms action. The in-depth exploration research area will provide new ideas strategies to enhance mitigate adverse effects.

Language: Английский

Citations

0
Development and Optimization of Curcumin-Loaded Citric Acid Functionalized Multi-Walled Carbon Nanotubes for Enhanced Breast Cancer Treatment Using Design of Experiment DOI

Saurabh Morparia,

Vasanti Suvarna

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)

Published: Feb. 28, 2025

Language: Английский

Citations

0
Network pharmacology and in vitro experiments based strategy to explore the effects of Jujuboside A on the proliferation and migration ability of glioma cells DOI

Q. Lv,

Lin Chen, Du Yuan

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149570 - 149570

Published: March 1, 2025

Language: Английский

Citations

0
Design, synthesis and biological activity of novel Xuetongsu derivatives as potential anticancer agents by inducing apoptosis DOI Creative Commons
Qi Jiang, Hui Zhong, Cong Wu

et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 40(1)

Published: April 8, 2025

Xuetongsu (XTS, Schisanlactone E) is one of the main active compounds and considered as star molecule isolated from Kadsura heteroclita (Roxb.) Craib. In order to improve XTS anti-tumour bioactivities, a series novel derivatives were designed synthesised by introducing an amide bond at parent. Anti-proliferative assays on four different human tumour cell lines (BGC-823, HepG-2, HCT-116, MCF-7) showed that activities most increased greatly compared parent XTS, especially, A-7, A-14, A-18 exhibited multiple effects. Among them, compound A-7 has best biological with IC50 values ranging 13.86 20.71 μM, which could significantly increase fraction apoptotic cells according flow cytometry experience. Further study demonstrated induce apoptosis HepG-2 through influencing key related proteins, such Bcl-2, Bax, cleaved Caspase-3.

Language: Английский

Citations

0
2‐Undecanone induces ferroptosis via the STAT3/GPX4 pathway to enhance sensitivity of renal cell carcinoma to sunitinib DOI
Zixuan Chen,

Chengtao Han,

Huiwen Xie

et al.

BioFactors, Journal Year: 2025, Volume and Issue: 51(2)

Published: March 1, 2025

Abstract The development of resistance significantly reduces the efficacy targeted therapies, such as sunitinib, in renal cell carcinoma (RCC) patients, emphasizing need for novel therapeutic agents. Natural products, known their diverse chemical structures and mechanisms action, offer promising anti‐tumor potential with favorable safety profiles lower toxicity compared to synthetic drugs. 2‐Undecanone, a natural compound extracted from Houttuynia cordata Thunb., has demonstrated effects, but its specific role RCC treatment remains unclear. In this study, we integrated network pharmacology vitro experiments explore underlying 2‐Undecanone's effects on RCC. Our results reveal that 2‐Undecanone effectively inhibits viability, proliferation, migration. Mechanistically, discovered induces ferroptosis cells by promoting reactive oxygen species (ROS) generation, intracellular Fe 2+ accumulation, glutathione (GSH) production, lipid peroxidation, modulation STAT3/GPX4 signaling pathway. Furthermore, lowers IC50 value sunitinib cells, enhancing sensitivity therapy. Additionally, potentiates sunitinib‐induced ferroptosis. summary, our research reveals enhances through targeting pathway, providing new insights into strategies

Language: Английский

Citations

0
Revealing the Mechanism of Esculin in Treating Renal Cell Carcinoma Based on Network Pharmacology and Experimental Validation DOI Creative Commons
Zixuan Chen,

Cunzhou Wang,

Yuesong Cai

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 1043 - 1043

Published: Aug. 22, 2024

Purpose: This study aims to explore the potential mechanisms of esculin in treatment renal cell carcinoma (RCC). Methods: We employed network pharmacology predict and targets RCC. Molecular docking techniques were then validate predicted targets. Additionally, a series vitro experiments conducted verify anticancer effects on RCC cells, including CCK-8 assay, EdU wound healing apoptosis Western blot. Results: Network molecular results identified GAPDH, TNF, GSK3B, CCND1, MCL1, IL2, CDK2 as core GO KEGG analyses suggested that may influence apoptotic processes target PI3K/Akt pathway Furthermore, assay demonstrated inhibited viability. Microscopic observations revealed following treatment, there was an increase crumpling, reduction density, accumulation floating dead cells. with increasing concentrations, proportion EdU-positive cells decreased, closure ratio PI-positive increased, expression levels BAX cleaved-caspase-3 proteins level Bcl2 protein decreased. These findings inhibits proliferation migration while promoting apoptosis. Moreover, found GAPDH inhibit pathway. Conclusions: is first elucidate therapeutic The provide evidence supporting clinical application introduce promising new candidate for treatment.

Language: Английский

Citations

1
Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities DOI Creative Commons

Wen-Zhe Nie,

Yalan Wang,

Xinlu Tian

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4193 - 4193

Published: Sept. 4, 2024

The emergence of natural products has provided extremely valuable references for the treatment various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is most abundant member cucurbitin family exhibits wide range biological activities, including anti-inflammatory, anti-cancer, even agricultural applications. Due to its high toxicity narrow therapeutic window, structural modification dosage form development are necessary address these issues with cucurbitacin B. This paper reviews recent research progress in pharmacological action, modification, application review aims enhance understanding advancements this field provide constructive suggestions further on

Language: Английский

Citations

1
Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma DOI Creative Commons

Sasikumar J. Soumya,

Kesavan R. Arya,

Chandran S. Abhinand

et al.

Published: Sept. 13, 2024

Glioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resistance that limits their clinical efficacy. A multi-target multi-drug approach has emerged as compelling strategies address this enhance the treatment outcomes. This review examines complex environment of anti-VEGF resistant GBM analyses using natural products.

Language: Английский

Citations

1
Determination of beneficial effects of cuminaldehyde on hyperglycemia associated kidney malfunctions DOI
Abhishek Das, Sumit Ghosh, Parames C. Sil

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

Citations

1
Jatropha Diterpenes: An Updated Review Concerning Their Structural Diversity, Therapeutic Performance, and Future Pharmaceutical Applications DOI Creative Commons
Thalisson Amorim de Souza, Leila Maria Moreira Beltrão Pereira, Alan Ferreira Alves

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1399 - 1399

Published: Oct. 19, 2024

The

Language: Английский

Citations

1