Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neuropsychiatric disorders DOI Creative Commons
Egon A. Ozer, Abdurrahman Keskin,

Yusuf Huseyin Berrak

et al.

Discover Mental Health, Journal Year: 2025, Volume and Issue: 5(1)

Published: Feb. 22, 2025

Viral infections may disrupt the structural and functional integrity of nervous system, leading to acute conditions such as encephalitis, neuropsychiatric mood disorders, schizophrenia, neurodegenerative diseases. Investigating viral interactions human proteins reveal mechanisms underlying these effects offer insights for therapeutic interventions. This study explores molecular virus that be related disorders. Herpes Simplex Virus-1 (HSV-1), Cytomegalovirus (CMV), Epstein-Barr Virus (EBV), Influenza A (IAV) (H1N1, H5N1), Human Immunodeficiency (HIV1&2) were selected key viruses. Protein structures each accessed from Data Bank analyzed using HMI-Pred web server detect interface mimicry between proteins. The PANTHER classification system was used categorize viral-human protein based on function cellular localization. Energetically favorable identified HSV-1 (467), CMV (514), EBV (495), H1N1 (3331), H5N1 (3533), HIV 1&2 (62425). Besides immune apoptosis-related pathways, including those associated with Parkinson's Huntington's diseases, frequently interacted. total 38 proteins, calmodulin 2, Ras-related botulinum toxin substrate 1 (Rac1), PDGF-β, vimentin, found interact all six indicates a substantial number energetically underscoring complexity breadth strategies hijack host mechanisms. Further in vivo vitro validation is required understand implications interactions.

Language: Английский

Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neuropsychiatric disorders DOI Creative Commons
Egon A. Ozer, Abdurrahman Keskin,

Yusuf Huseyin Berrak

et al.

Discover Mental Health, Journal Year: 2025, Volume and Issue: 5(1)

Published: Feb. 22, 2025

Viral infections may disrupt the structural and functional integrity of nervous system, leading to acute conditions such as encephalitis, neuropsychiatric mood disorders, schizophrenia, neurodegenerative diseases. Investigating viral interactions human proteins reveal mechanisms underlying these effects offer insights for therapeutic interventions. This study explores molecular virus that be related disorders. Herpes Simplex Virus-1 (HSV-1), Cytomegalovirus (CMV), Epstein-Barr Virus (EBV), Influenza A (IAV) (H1N1, H5N1), Human Immunodeficiency (HIV1&2) were selected key viruses. Protein structures each accessed from Data Bank analyzed using HMI-Pred web server detect interface mimicry between proteins. The PANTHER classification system was used categorize viral-human protein based on function cellular localization. Energetically favorable identified HSV-1 (467), CMV (514), EBV (495), H1N1 (3331), H5N1 (3533), HIV 1&2 (62425). Besides immune apoptosis-related pathways, including those associated with Parkinson's Huntington's diseases, frequently interacted. total 38 proteins, calmodulin 2, Ras-related botulinum toxin substrate 1 (Rac1), PDGF-β, vimentin, found interact all six indicates a substantial number energetically underscoring complexity breadth strategies hijack host mechanisms. Further in vivo vitro validation is required understand implications interactions.

Language: Английский

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