Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116457 - 116457
Published: March 22, 2024
Ferroptosis, distinct from apoptosis, necrosis, autophagy, and other types of cell death, is a novel iron-dependent regulated death characterized by the accumulation lipid peroxides redox imbalance with morphological, biochemical, genetic features. Dysregulation iron homeostasis, disruption antioxidative stress pathways peroxidation are crucial in ferroptosis. Ferroptosis involved pathogenesis several cardiovascular diseases, including atherosclerosis, cardiomyopathy, myocardial infarction, ischemia-reperfusion injury, abdominal aortic aneurysm, dissection, heart failure. Therefore, comprehensive understanding mechanisms that regulate ferroptosis diseases will enhance prevention treatment these diseases. This review discusses latest findings on molecular its regulation application modulators role traditional Chinese medicines to provide identify new options.
Language: Английский
Citations
9Hederagenin promotes lung cancer cell death by activating CHAC1-dependent ferroptosis pathway
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 718, P. 150085 - 150085
Published: May 8, 2024
Language: Английский
Citations
6An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: June 19, 2024
Hederagenin (HG) is a natural pentacyclic triterpenoid that can be isolated from various medicinal herbs. By modifying the structure of HG, multiple derivatives with superior biological activities and safety profiles have been designed synthesized. Accumulating evidence has demonstrated HG its display pharmacological against cancers, inflammatory diseases, infectious metabolic fibrotic cerebrovascular neurodegenerative depression. Previous studies confirmed combat cancer by exerting cytotoxicity, inhibiting proliferation, inducing apoptosis, modulating autophagy, reversing chemotherapy resistance in cells, action targets involved mainly include STAT3, Aurora B, KIF7, PI3K/AKT, NF-κB, Nrf2/ARE, Drp1, P-gp. In addition, antagonize inflammation through production release pro-inflammatory cytokines mediators regulating inflammation-related pathways targets, such as MAPK, JAK2/STAT3, Keap1-Nrf2/HO-1, LncRNA A33/Axin2/β-catenin. Moreover, anti-pathogen, anti-metabolic disorder, anti-fibrosis, neuroprotection, anti-depression mechanisms partially elucidated. The diverse properties hold significant implications for future research development new drugs derived which lead to improved effectiveness profiles.
Language: Английский
Citations
4Quercetin Alleviates LPS-Stimulated Myocardial Injury through Regulating ALOX5/PI3K/AKT Pathway in Sepsis
Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(10), P. 1116 - 1124
Published: July 28, 2024
Language: Английский
Citations
4Diselenide Nanogels Modulate Mitochondrial Function and Mitigate Oxidative Stress in Cardiomyocytes for Enhanced Cardiac Repair
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Mitochondrial dysfunction and oxidative stress are pivotal factors contributing to the loss of cardiac function following heart injury, yet these aspects frequently underappreciated in medication design paradigm. Here we have developed diselenide-cross-linked zwitterionic nanogels restore mitochondrial homeostasis boost energy supply for damaged repair. These exhibit an enhanced circulation time within bloodstream post systemic administration been observed concentrate at site myocardium both myocardial infarct (MI) rat model cardiotoxic mouse model. Our mechanistic investigations revealed that capacity mitigate microenvironment, thereby preserving cardiomyocytes. Moreover, degradation products shown upregulate intracellular ATP synthesis, which turn increases contractility promotes recovery function. The innovative nanogel system presented herein holds significant potential clinical translation, offering a therapeutic strategy restoration fresh perspective on maintaining metabolism treatment injury.
Language: Английский
Citations
0Traditional Chinese Medicine for Inhibiting Ferroptosis in Ischemic‐Related Diseases
Basic & Clinical Pharmacology & Toxicology, Journal Year: 2025, Volume and Issue: 136(6)
Published: April 28, 2025
ABSTRACT Ischemic‐related diseases, such as myocardial infarction and stroke, are primarily driven by a deficit in oxygen supply leading to cellular damage death. Ferroptosis has emerged an important mechanism contributing the progression of ischemic injury, characterized iron‐dependent lipid peroxidation. This review aims provide comprehensive overview significant mechanisms underlying ferroptosis conditions explores potential effects traditional Chinese medicines (TCMs) their extracts. Numerous compounds extracted from TCMs, including flavonoids, polyphenols terpenes, exhibit potent antiferroptotic activating nuclear factor erythroid 2–related 2, upregulating glutathione peroxidase 4, inhibiting peroxidation so on. These properties render TCMs promising candidate for developing novel therapeutic strategies. underscores importance investigating interactions between within context diseases. findings valuable insights future research identify targets associated with regulation, thereby expanding pharmacological perspective treating diseases revealing Additionally, this highlights relevance integrating modern medical approaches addressing complex health issues.
Language: Английский
Citations
0Hederagenin ameliorates ferroptosis-induced damage by regulating PPARα/Nrf2/GPX4 signaling pathway in HT22 cells: An in vitro and in silico study
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 155, P. 108119 - 108119
Published: Dec. 30, 2024
Language: Английский
Citations
0Pentacyclic triterpenes, potential novel therapeutic approaches for cardiovascular diseases
Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(8-9), P. 709 - 735
Published: July 24, 2024
Language: Английский
Citations
0An emerging double‑edged sword role of ferroptosis in cardiovascular disease (Review)
International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(1)
Published: Nov. 11, 2024
The pathophysiology of cardiovascular disease (CVD) is complex and presents a serious threat to human health. Cardiomyocyte loss serves pivotal role in both the onset progression CVD. Among various forms programmed cell death, ferroptosis, along with apoptosis, autophagy pyroptosis, closely linked advancement Ferroptosis, mechanism driven by buildup oxidized lipids excess iron. This pathway modulated lipid, amino acid iron metabolism. Key characteristics ferroptosis include disrupted homeostasis, increased peroxidation polyunsaturated fatty acids due reactive oxygen species, decreased glutathione levels inactivation peroxidase 4. Treatments targeting could potentially prevent or alleviate CVD inhibiting pathway. Ferroptosis integral pathogenesis several types its occurrence cardiomyocytes be promising therapeutic strategy for future treatment present review provided an in‑depth analysis advancements understanding mechanisms underlying ferroptosis. manuscript summarized interplay between CVDs, highlighting dual roles these conditions. Additionally, potential targets within were discussed, alongside current limitations directions novel strategies. may offer insights into preventive approaches CVDs.
Language: Английский
Citations
0Fluorescence-Based Imaging Techniques
Published: Jan. 1, 2024
Citations
0