The Potential Role of Phytochemicals in Alzheimer’s Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 653 - 653

Published: Feb. 12, 2025

Alzheimer’s disease (AD) is a neurodegenerative condition characterised by memory loss and cognitive disorders. The has been related to the presence of so-called senile plaques forming due buildup amyloid β in hippocampus. AD therapies developed date continue prove insufficient, while long-term exposure synthetic drugs tends lead serious side effects, which why potential herbal treatments are generally preferable conventional drug regimens and, as such, have under considerable research scrutiny recent years. There number herbs, e.g., lavender Ginkgo biloba, that already commonly employed alleviating symptoms certain neurological In light above, aim following paper discuss importance medicinal their neuroprotective properties, mechanisms activity. article presents review identified therapeutic properties phytomedicines exhibit strong anti-Alzheimer’s

Language: Английский

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The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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A new name for an old problem—Colletotrichum cigarro is the cause of St John’s wilt of Hypericum perforatum

Frontiers in Fungal Biology, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 23, 2025

A major problem for St John’s wort ( Hypericum perforatum ) is wilt, which can lead to reduced crop yields and even complete losses. In the past, pathogen was referred as Colletotrichum gloeosporioides or occasionally cf. based on morphology. Although a strain from this host had been re-identified C. cigarro in taxonomic studies, there uncertainty about identity of wilt pathogen, generally still addressed applied science. multi-locus [internal transcribed spacer (ITS), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), actin (ACT), glutamine synthetase (GS)] analysis species complex, all isolates obtained newly collected symptomatic H. stems seeds Germany Switzerland were identified cigarro. they belonged same haplotype, morphology very variable. Pathogenicity tests demonstrated that only strains cause symptoms , whereas other tested caused latent infection .

Language: Английский

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Elicitation of Hypericum perforatum L. hairy root cultures with salicylic acid and jasmonic acid enhances the production of phenolic compounds and naphthodianthrones with biological activities

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2025, Volume and Issue: 160(3)

Published: Feb. 17, 2025

Language: Английский

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Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318539 - e0318539

Published: March 4, 2025

Candida albicans (C. albicans) is an opportunistic pathogen in immunocompromised individuals and a normal inhabitant of the oral cavity, throat, gastrointestinal tract, genitourinary system among health populations. Our study focused on identifying new inhibitors capable binding to mutant cytochrome P450 family 51 (CYP-51) protein intended be effective against resistant C. infections. The pharmacophore ligand-based model was used for virtual screening compound libraries. Molecular docking performed Maestro, Schrodinger. ADMET analysis check drug-likeness properties. Density function theory (DFT) calculations, molecular dynamic (MD) simulation, free energy (MMPBSA) were also calculated. For docking, six compounds selected from 11,022 hits PubChem libraries, which showed best interaction with CYP-51 identified by mapping Pharma IT tool. Each docked into active site protein. Overall, CP-3 exhibited significant affinity (-10.70 kcal/mol) as well as, good characteristics such drug-likeness, absorption, distribution, metabolism, excretion, toxicity. lead compound, CP-3, further MD simulation observe behavior complex Computational studies indicated that could useful antagonist protein, CYP-51. This computational approaches identify potential targeting antifungal drug development. Further invitro vivo are needed evaluate its pharmacokinetic properties efficacy novel drug.

Language: Английский

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The Potential of Selected Plants and Their Biologically Active Molecules in the Treatment of Depression and Anxiety Disorders

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2368 - 2368

Published: March 6, 2025

The incidence of anxiety and depression disorders is increasing worldwide. There an hard-to-treat with various aspects origin. Almost 80% people prefer to use natural remedies supplements as their primary healthcare solution. Not surprisingly, around one-third drugs were inspired by nature. Over the past three decades, such has increased significantly. Synthetic antidepressants may cause negative side effects, whereas herbal medicines are favored because ability relieve symptoms minimal no effects lower financial burden. This review provides overview herbs biologically active compounds used treat depression.

Language: Английский

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An Overview of the Bioactivity of Spontaneous Medicinal Plants Suitable for the Improvement of Lung Cancer Therapies

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 336 - 336

Published: March 5, 2025

Lung cancer is the second cause of death in world, being most common type cancer. Conventional therapies are not always recommended due to particularities patients. Thus, there a need develop new anticancer therapeutic agents. Medicinal plants constitute source bioactive compounds with potential lung The purpose our narrative review evaluate and summarize main studies on cytotoxic effects ten medicinal their extracts, volatile oils, compounds. We have also included that reported protective these natural products against chemotherapy-induced toxicity. Studies were identified by assessing five databases using specific keywords. investigated possess cell cultures. Several mechanisms action been proposed including apoptosis, necrosis or autophagy, cycle arrest, modulation signaling pathways (PI3K/Akt MAPK), inhibition migration, invasion metastasis, antiangiogenesis, targeting inflammation. Different exhibit shown promising results. To agents useful treating cancer, this should be more deeply reveal molecular action.

Language: Английский

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Unlocking New Pharma/Nutraceutical Frontiers With Neuroprotective Properties of Three Hypericum Species: A Study Combination With In Vitro and In Silico Methodologies

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT This study investigates the phytochemical composition and biopharmacological potential of three Hypericum species ( H. scabrum , lysimachioides uniglandulosum ) from Turkey. Aqueous hydroalcoholic extracts were analyzed for their total phenolic content (TPC), flavonoid (TFC), individual components (by UHPLC–HRMS technique). Antioxidant activities investigated by DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, metal chelating assays. The inhibition effects tested on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, glucosidase examined. One hundred compounds identified in chemical composition, specific genus such as hyperoside, hypericin, pseudohypericin, detected. highest TPC was detected ethanol/water extract with 69.21 mg GAE/g. Furthermore, showed strongest free radical reducing effect. more active than water extracts. Neuroprotective assessments indicated downregulation COX‐2 NOS‐2 genes LPS‐stimulated mouse cortex models, alongside modulation SERT NET expression, suggesting reduced neuroinflammation enhanced neurotransmitter release. Molecular docking dynamics analyses highlighted strong binding interactions, especially NET_hyperoside NET_myricitrin complexes. results indicate significant therapeutic these extracts, supporting development natural agents against oxidative stress, neuroinflammation, related neurodegenerative diseases.

Language: Английский

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Role and mechanism of herbal bioactives in treatment of Parkinson disease: A promising therapeutic approach

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 181, P. 315 - 338

Published: April 25, 2025

Language: Английский

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Hypericum hircinum L.: Botany, Traditional Uses, Phytochemistry, and Pharmacological Properties

Plants, Journal Year: 2025, Volume and Issue: 14(10), P. 1451 - 1451

Published: May 13, 2025

Hypericum hircinum L., commonly known as goat St. John’s wort or stinking tutsan, is a medicinal plant native to the Mediterranean basin and widespread across Europe parts of Middle East. It has long history traditional uses in folk medicine treat respiratory diseases, wounds, burns relieve migraine, rheumatism, muscular pains. Despite numerous scientific studies shading light on phytochemical profile beneficial properties extracts, comprehensive overview current knowledge missing. In this paper, we summarized available information botany, uses, phytochemistry, pharmacological from peer-reviewed articles published till March 2025 PubMed, ScienceDirect, Wiley, Springer, ACS, Scielo, Web Science databases. The presence valuable compounds, including terpenes, phenolic acids, flavonoids, phloroglucinols, reported well wide range properties, such antimicrobial, antifungal, antiviral, antidepressant, anti-collagenase, anti-α-glucosidase, antioxidant activities, together with non-pharmacological properties. data review contribute deeper understanding biological species pave way for further investigation its potential applications.

Language: Английский

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