Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy DOI Creative Commons

Runyan Niu,

Xuexue Liu, Xian Yang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 68 - 68

Published: Jan. 6, 2025

Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to simple methods, high efficiency, suitability large-scale industrial production. This innovative approach presents new opportunities enhance both safety therapeutic efficacy cancer treatments. review comprehensively explores recent progress in application PDANSs therapy. It begins detailing self-assembly mechanisms fundamental principles underlying PDANS formation. The discussion then advances strategies assembling single nanoparticles, well co-assembly multiple drugs. Subsequently, addresses combination treatment modalities, encompassing diagnostic applications. These include combinations chemotherapeutic agents, phototherapeutic approaches, integration chemotherapy with phototherapy, synergistic use immunotherapy other methods. Finally, highlights advancing tumor therapy prospects application, providing key insights future aimed at optimizing technology broadening its utility treatment.

Language: Английский

Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy DOI Creative Commons

Runyan Niu,

Xuexue Liu, Xian Yang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 68 - 68

Published: Jan. 6, 2025

Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to simple methods, high efficiency, suitability large-scale industrial production. This innovative approach presents new opportunities enhance both safety therapeutic efficacy cancer treatments. review comprehensively explores recent progress in application PDANSs therapy. It begins detailing self-assembly mechanisms fundamental principles underlying PDANS formation. The discussion then advances strategies assembling single nanoparticles, well co-assembly multiple drugs. Subsequently, addresses combination treatment modalities, encompassing diagnostic applications. These include combinations chemotherapeutic agents, phototherapeutic approaches, integration chemotherapy with phototherapy, synergistic use immunotherapy other methods. Finally, highlights advancing tumor therapy prospects application, providing key insights future aimed at optimizing technology broadening its utility treatment.

Language: Английский

Citations

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