Oxymatrine impedes Alzheimer’s progression via the attenuation of hypercholesterolemia and fibrosis DOI
Ashmita Das,

Rahul Manna,

Durlav Chowdhury

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(5)

Published: April 17, 2025

Language: Английский

A high cholesterol diet accelerates Alzheimer's progression by promoting fibrotic damage in rats DOI Creative Commons
Ashmita Das, Dhuly Chowdhury, D. P. Sharma

et al.

Brain Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100206 - 100206

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advanced strategies for enhancing the neuroprotective potential of curcumin: delivery systems and mechanistic insights in neurodegenerative disorders DOI
Pratikeswar Panda, Sanjib Mohanty,

Sangita Ranee Gouda

et al.

Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: March 3, 2025

Background: Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant neuroprotective potential due to its diverse pharmacological properties.Objective: This review explores curcumin's role in modulating key pathological mechanisms underlying neurodegenerative disorders such as Alzheimer's, Parkinson's diseases, Amyotrophic Lateral Sclerosis, Huntington's Disease and Prion Disease.Methods: A comprehensive analysis of molecular interactions, including effects on amyloid-beta (Aβ) aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, metal-induced neurotoxicity, was conducted. Additionally, strategies overcome low bioavailability blood-brain barrier (BBB) permeability were evaluated.Results: Curcumin inhibits Aβ aggregation promotes disaggregation, reducing amyloid plaque formation Alzheimer's disease. It modulates glial cell activity, attenuating neuroinflammation fostering environment. By interacting with proteins, curcumin prevents hyperphosphorylation neurofibrillary tangle formation. As potent antioxidant, it scavenges reactive oxygen species, mitigating stress-related neuronal damage. Its metal-chelating properties further diminish neurotoxicity by sequestering iron copper ions. Despite limited BBB permeability, therapeutic efficacy can be enhanced using nanocarriers nanoparticles, liposomes, micelles, which improve solubility, stability, brain penetration.Conclusion: Curcumin's multifaceted make promising candidate for preventing or slowing disease progression. Advanced drug delivery systems hold overcoming pharmacokinetic limitations, paving the way future clinical applications.

Language: Английский

Citations

0
Oxymatrine impedes Alzheimer’s progression via the attenuation of hypercholesterolemia and fibrosis DOI
Ashmita Das,

Rahul Manna,

Durlav Chowdhury

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(5)

Published: April 17, 2025

Language: Английский

Citations

0