New Halogenated Chalcones as Potential Anti-Inflammatory Agents: A Comprehensive In-Silico, In-Vitro, and In-Vivo Study with ADME Profiling DOI
Rabia Iqtadar, Asia Naz, Syed Adnan Alı Shah

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141055 - 141055

Published: Dec. 1, 2024

Language: Английский

Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems DOI Creative Commons

Hadeer M. Diab,

Ismail A. Abdelhamid, Mostafa E. Salem

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 101726 - 101726

Published: Aug. 1, 2024

Language: Английский

Citations

4
Synthesis, cytotoxic evaluation, and binding studies of novel Sulphamethoxazole-based Cyanoacrylamides as potential antitumor agents DOI Creative Commons

Fatma G. Mohamed,

Mohamed A. Ragheb, Ahmed H. M. Elwahy

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102119 - 102119

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis, and antibacterial activities of novel 1,3,4a,9-tetraza-4H-fluoren-2-amines incorporating phenoxy-N-arylacetamide, pyrazole, and 2-(4-(1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide moieties DOI Creative Commons

Reham E. Abdelwahab,

Ahmed H. M. Elwahy,

Nada S. Ibrahim

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 8, 2025

Abstract A ring annelation reaction was used to successfully prepare benzo[4,5]imidazo[1,2- a ][1,3,5]triazines (Systematic Name: 1,3,4a,9-tetraza-4 H -fluoren-2-amines) tethered phenoxy- N -arylacetamide, pyrazole, and 2-(4-(1-phenyl-1 -pyrazol-3-yl)phenoxy)- -arylacetamide moieties utilizing 1-(1 -benzo[ d ]imidazol-2-yl)guanidine the proper aldehydes as precursors. 2-(Phenylamino)ethyl fragment of compound 7 cleaved off 8 formed. The constitutions novel compounds were confirmed based on spectral data. antibacterial activity evaluated for prepared against two gram-negative gram-positive bacteria. Among them, 12b (inhibition zone 16 ± 0.7 mm) most promising S. aureus compared Gentamycin (15 0 mm). Also, 5a 5d exerted comparable zones 13 1.4 2.1 mm), respectively . Minimum inhibitory concentration (MIC) evaluation showed that had lowest MIC value (78.1 µg/mL).

Language: Английский

Citations

0
Anti-Cancer Potential of Dehydrozingerone's Phenoxy-Acetamide Derivatives: Discovery of a Potent Lead with Dual Anti-Proliferative and Anti-Metastatic Activities DOI

Chetan Kumar,

Anshurekha Dash, Rohit Kumar Singh

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108413 - 108413

Published: March 1, 2025

Language: Английский

Citations

0
Synthesis, molecular docking simulation, and antimicrobial activities of novel fused pyrimidine systems linked to N-arylacetamide and vanillin units as novel hybrid molecules via Hantzsch and Biginelli reactions DOI

Ibrahim M. Z. Fares,

Mostafa E. Salem,

Merihan Saad Shafik

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142345 - 142345

Published: April 1, 2025

Language: Английский

Citations

0
Synthesis and Antileishmanial Evaluation of N-Phenyl-2-phenoxyacetamides Derived from Carvacrol DOI Creative Commons

Rayane Luiza de Carvalho,

Alessandra da Silva,

Bianca Muniz Lacerda Ventura

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Folic acid-modified chitosan nanoparticles for targeted delivery of a binuclear Co(II) complex in cancer therapy DOI
Mohamed A. Ragheb, Mona S. Ragab, Moustafa AFH Mahdy

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144034 - 144034

Published: May 1, 2025

Language: Английский

Citations

0
Novel α-Cyano-Indolyl Chalcones as Anti-Cancer Candidates, Induce G1/S Cell Cycle Arrest and Sequentially Activate Caspases-7, 8 , and 9 in Breast Carcinoma DOI
Alaa A. Kashmiry,

Nada S. Ibrahim,

Magda F. Mohamed

et al.

Polycyclic aromatic compounds, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: Oct. 14, 2024

Six substituted α-cyano-indolylchalcones have been prepared and their structures were verified by various spectral analysis tools. Compared with the standard drug 5-Fluorouracil) 5-FU(, anticancer activity against prostate cancer (PC3) breast cell line (MCF7) was determined using cytotoxic MTT assay. Also, effect normal melanocytes (HFB4) studied to detect selectivity of compounds. Among series, compound 3e most active selective one toward MCF7 (IC50= 0.18 µmole/mL, SI= 7.6). In silico studies performed demonstrate inhibitory on EGFRK, CDK2, MDM2 domains. Different molecular techniques know efficacy novel apoptotic death carcinoma cells.

Language: Английский

Citations

2
Synthesis, antimicrobial, DNA binding, and computational studies of some bis- and poly(4-methyl-2H-chromen-2-one) derivatives DOI

Ibrahim M. Z. Fares,

Mohamed A. Ragheb, Ismail A. Abdelhamid

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140790 - 140790

Published: Nov. 1, 2024

Language: Английский

Citations

2
New Halogenated Chalcones as Potential Anti-Inflammatory Agents: A Comprehensive In-Silico, In-Vitro, and In-Vivo Study with ADME Profiling DOI
Rabia Iqtadar, Asia Naz, Syed Adnan Alı Shah

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141055 - 141055

Published: Dec. 1, 2024

Language: Английский

Citations

0