Metformin Alleviates Doxorubicin-Induced Cardiotoxicity via Preserving Mitochondrial Dynamics Balance and Calcium Homeostasis

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Doxorubicin (DOX) is a commonly used chemotherapeutic medication for treating malignancies, although its cardiotoxicity limits use. There growing evidence that alteration of the mitochondrial fission/fusion dynamic processes accompanied by excessive reactive oxygen species (ROS) production and calcium Ca 2+ homeostasis are potential underlying mechanisms DOX-induced (DIC). Metformin (Met) an AMP-activated protein kinase (AMPK) activator has antioxidant properties cardioprotective effects. The purpose study to assess Met's possible benefits against cardiotoxicity. included 32 adult male rats. They were randomly divided into four groups: administered saline, DOX, Met, or DOX combined with Met respectively. Heart tissues biochemical assays measured oxidative stress markers, malondialdehyde (MDA), reduced glutathione (GSH), dynamics optic atrophy-1(OPA-1) dynamin-1-like (Drp1), calcineurin caspase-3. Serum levels myocardial injury cardiac troponin I (cTn-I), aspartate aminotransferase (AST), also measured. results revealed intoxication was associated significant increase in serum cTn-I AST, increased MDA level, Drp1, calcineurin, caspase-3 expressions, as well GSH level OPA-1 expression. On other hand, treatment significantly DIC decreasing stress, apoptosis, improving balance. Finally, this shows may be able protect heart from damage caused working anti-apoptotic agent keeping balance mitochondria.

Language: Английский

Prospective Hepatoprotective Actions of Novel Nano-formulations of Sildenafil and Neem Extract in Counteracting Oral Carbon Tetrachloride-induced Liver Injury in Rats

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)

Published: April 1, 2025

Language: Английский

Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure

BMC Pharmacology and Toxicology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 8, 2024

Acute liver failure (ALF) is a critical condition characterized by rapid dysfunction, leading to high mortality rates. Current treatments are limited, primarily supportive, and often require transplantation. This study investigates the potential of novel nanoparticle formulation glutathione (GSH) virgin coconut oil (VCO) alone in combination enhance therapeutic outcomes rat model ALF induced orogastric carbon tetrachloride (CCl

Language: Английский