Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Niclosamide, initially developed as an anthelmintic, has recently emerged a potential antiviral, showing efficacy against diverse viral threats, including Mpox. As the global health landscape faces recurrent Mpox outbreaks, repurposing niclosamide through advanced material strategies offers promising therapeutic avenues. This article explores antiviral mechanisms of niclosamide, focusing on how innovative nano‐hybrid formulations enhance its bioavailability and pharmacological performance. By leveraging nanohybridization, niclosamide's limitations—such poor solubility bioavailability—are addressed, enabling targeted delivery sustained release. Early preclinical studies reveal that disrupts replication entry processes, suggesting utility option poxvirus infections. Looking forward, further in vitro, animal models, clinical investigations are essential to optimize application dosing for With continued development materials, nanohybrid could become critical tool managing related offering accessible, cost‐effective outbreak preparedness.

Language: Английский

From pox to protection: understanding Monkeypox pathophysiology and immune resilience

Tropical Medicine and Health, Journal Year: 2025, Volume and Issue: 53(1)

Published: Feb. 26, 2025

Abstract The Monkeypox virus (MPXV), which causes (Mpox) is an invasive ailment with global implications. MPXV, categorized within the Orthopoxvirus genus, exhibits diverse clades varying fatality rates. Initially discovered in monkeys and later humans, disease predominantly affects regions across West Central Africa. Clinical manifestations encompass a spectrum from mild flu-like symptoms to severe eruptions. This article aims give scientific community comprehensive overview of Mpox Pathophysiology delve into intricate landscape host immune responses against MPXV infection. It offers crucial insights virus's Pathophysiology, spanning its entry, replication, dissemination, elicited responses. reaction involves innate immunity, B-cell T-cell immunity. Moreover, this review underscores immunological response resistance mechanisms MPXV. also highlights imperative research areas warranting prioritization devise more efficacious treatments for controlling viral propagation healthcare systems. In addition, it gives us look possible futures that could help progress immunotherapies cutting-edge biotechnological solutions protecting

Language: Английский

Current status of next-generation vaccines against mpox virus: a scoping review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Introduction The mpox disease, caused by the virus (MPXV), has become a rising public health issue due to its potential cause outbreaks. Consistently, this investigation aims evaluate current advances in development of novel immunotherapeutic approaches against MPXV, which are crucial for preventing and controlling spread. Methods This scoping review was performed analyzing content English-language articles published between 2018 2024, reported next-generation vaccines MPXV their assessment animal models. Patents within scope research were also included. Contrarywise, studies based solely on immunoinformatic methods, reviews, book chapters, news, others excluded. literature search executed 11 databases, such as Scopus, MEDLINE, PubMed. Results A total 36 records (32 4 patents) included review. All 32 contain preclinical with varied group sizes (4–16) main models BALB/c mice. Less commonly used CAST/Ei mice cynomolgus macaques. Moreover, most targeted one or more antigens, A29L, A35R, B6R, M1R, through active immunization (via mRNAs recombinant antigens) passive (antibody delivery). Conclusion Overall, new generation might represent prospective candidates combat concern. Nonetheless, several analyzed possess drawbacks, including limited similarity humans, small sizes, brief follow-up durations. Consequently, additional is required ascertain long-term protection, efficacy, safety these approaches.

Language: Английский