A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality
Frontiers in Toxicology,
Journal Year:
2024,
Volume and Issue:
6
Published: Oct. 17, 2024
Introduction
Triclosan
is
an
antibacterial
and
antifungal
compound
that
frequently
found
in
personal
care
consumer
products,
its
impact
on
male
reproductive
health
a
growing
concern.
Despite
existing
experimental
studies
demonstrating
potential
threats
to
fertility,
reports
effects
human
semen
quality
remains
limited
inconsistent.
Therefore,
this
study
presents
systematic
review
meta-analysis
assessing
the
relationship
between
triclosan
exposure
quality.
Methods
This
was
registered
with
PROSPERO
(CRD42024524192)
adhered
PRISMA
guidelines.
Results
The
analyzed
562
screened
studies,
out
of
which
five
articles
including
1,312
subjects
were
finally
included
study.
eligible
geographically
diverse,
three
from
China,
one
Belgium,
Poland.
More
so,
both
case-control
cross-sectional.
revealed
significantly
reduced
sperm
concentration
(Standard
Mean
Difference
(SMD)
−0.42
[95%
CI:
−0.75,
−0.10],
P
=
0.01)
total
motility
(SMD
−1.30
−2.26,
−0.34],
0.008).
Mechanistic
insights
animal
vitro
showed
oxidative
stress
may
mediate
adverse
Discussion
first
comprehensive
evaluation
quality,
highlighting
impair
fertility
through
reductions
motility.
However,
high
heterogeneity
among
underscores
need
for
further
high-quality
research
establish
more
definitive
conclusions
regarding
health.
Language: Английский
Editorial: Environmental threats to human reproduction
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 2, 2024
These
environmental
stressors
acts
via
multiple
pathways.
First,
they
disrupt
the
endocrine
system
by
mimicking
or
blocking
sex
hormones
(Akhigbe
et
al.,
2022).
They
may
also
induce
oxidative
stress
upregulating
generation
of
free
radicals
and
suppressing
antioxidants
(Kumar
2018;Akhigbe
2021),
trigger
inflammation
immune
response
(Li
2021;Ashonibare
2024b),
promote
genotoxicity
(Choudhuri
2021)
Although
SARS-CoV-2
remains
quite
novel,
convincing
evidences
have
been
provided
on
its
possible
link
with
infertility
Hamed,
2020;Adeyemi
2022)
Language: Английский