A brain-targeted and ROS-responsive natural polysaccharide nanogel for enhancing antidepressant therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160719 - 160719

Published: Feb. 1, 2025

Language: Английский

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Decoding the interaction of an imidazo-pyrimidine derivative with serum proteins: Spectroscopic, computational and structure-activity relationship analysis

Biophysical Chemistry, Journal Year: 2025, Volume and Issue: 322, P. 107435 - 107435

Published: March 14, 2025

Language: Английский

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Acetyl-L-Carnitine as an Add-On Treatment in Fibromyalgia Syndrome: A Retrospective Analysis on 183 Patients, According to the Generalized Linear Mixed Model for Longitudinal Data

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 820 - 820

Published: March 28, 2025

Background. Fibromyalgia Syndrome (FMS) is characterized by chronic widespread pain, sleep disturbances, fatigue and cognitive impairment. Methods. In this retrospective study, we analyzed data collected between 2017 2022 regarding Acetyl-L-Carnitine (ALC) as an add-on treatment in 183 adult patients with FMS according to the 2016 ACR (American College of Rheumatology) criteria patients’ pain lasting for over three months. Patients prior exposure ALC or without informed consent were excluded. Results. Regarding efficacy, 137 patients, change from baseline end observation Visual Analogue Scale score (VAS) was statistically significant, ranging 75.9 ± 1.56 51.9 1.99 (p < 0.001). concomitant drug treatments achieved better VAS reduction than who not drug-free at baseline. quality life, a significant improvement Revised Impact Questionnaire (FIQ-R) evidenced, 75.1 1.13 53.5 1.34 The Short Form 12 Health Survey (SF12) scores showed both physical mental components. Finally, Pittsburgh Sleep Quality Index (PSQI) did show difference whole population, 23 (16.7%) reported Adverse Events (AEs), predominantly insomnia, shivering, headaches, nausea. Only six reporting AEs discontinued treatment. Conclusions. This study evidenced efficacy safety patients. may represent useful approach, particularly long-term treatments. Methodologically stronger studies will be necessary validate our observations.

Language: Английский

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Hyaluronic Acid: A Comprehensive Review of Its Osteogenic Potential and Diverse Biomedical Applications

Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 10, 2025

Language: Английский

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