Heart Failure and Arrhythmias: Circadian and Epigenetic Interplay in Myocardial Electrophysiology DOI Open Access
Zhu Chen, Shuang Li, Yihong Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2728 - 2728

Published: March 18, 2025

Emerging evidence underscores the impact of circadian rhythms on cardiovascular processes, particularly in conditions such as hypertension, myocardial infarction, and heart failure, where rhythm disruptions are linked to disease progression adverse clinical outcomes. Circadian clock proteins intricately electrophysiological remodeling epigenetic pathways associated with arrhythmias failure. In context dysregulation leads cardiomyocytes, which can precipitate life-threatening ventricular tachycardia (VT) fibrillation (VF). This may be influenced by environmental factors, diet exercise, well genetic factors. Moreover, modifications failure have been implicated regulation genes involved cardiac hypertrophy, fibrosis, inflammation. The interplay between proteins, remodeling, failure-related is complex multifaceted. Further research needed elucidate how these processes interact contribute development patients. review aims explore connections rhythms, electrophysiology, related goal identifying potential therapeutic targets interventions that counteract effects health.

Language: Английский

Senotherapeutic approach to age-related endocrine diseases DOI
Seda Turgut,

Gülnur Andican

Advances in pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Heart Failure and Arrhythmias: Circadian and Epigenetic Interplay in Myocardial Electrophysiology DOI Open Access
Zhu Chen, Shuang Li, Yihong Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2728 - 2728

Published: March 18, 2025

Emerging evidence underscores the impact of circadian rhythms on cardiovascular processes, particularly in conditions such as hypertension, myocardial infarction, and heart failure, where rhythm disruptions are linked to disease progression adverse clinical outcomes. Circadian clock proteins intricately electrophysiological remodeling epigenetic pathways associated with arrhythmias failure. In context dysregulation leads cardiomyocytes, which can precipitate life-threatening ventricular tachycardia (VT) fibrillation (VF). This may be influenced by environmental factors, diet exercise, well genetic factors. Moreover, modifications failure have been implicated regulation genes involved cardiac hypertrophy, fibrosis, inflammation. The interplay between proteins, remodeling, failure-related is complex multifaceted. Further research needed elucidate how these processes interact contribute development patients. review aims explore connections rhythms, electrophysiology, related goal identifying potential therapeutic targets interventions that counteract effects health.

Language: Английский

Citations

0