Editorial: Spanning the spectrum of social behavior: towards more translationally relevant animal models

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Solitude and serotonin: juvenile isolation alters the covariation between social behavior and cFos expression by serotonergic neurons

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 22, 2024

Variation in the mutual responsiveness of social partners to each other can be reflected behavioral suites that covary with neural activity ways track salience or valence interactions. Juvenile isolation alters behavior and during interaction, but whether how it covariation between has not been as well explored. To address this issue, four classes experimental subjects: isolated males, socially housed females, were paired an opposite-sex partner had housed. Social behaviors c-Fos expression serotonergic dorsal raphe nucleus (DRN) then measured subjects following Relative housing, postweaning led a decrease density neurons double-labeled for tryptophan hydroxylase dorsomedial subdivision DRN, regardless sex. Vocal non-vocal also affected by isolation. In interactions both ultrasonic vocalization (USVs) broadband vocalizations (squeaks) increased conjunction greater male investigation females. Neural measures correlated other. group, DRN was negatively USV production positively principal component corresponding defensive kicking females less mounting behavior. This correlation reversed direction males versus These findings confirm dynamics are activation suggest altered interaction parallel response female cues.

Language: Английский

Uncovering hidden prosocial behaviors underlying aggression motivation in mice and young children

Behavioral and Brain Functions, Journal Year: 2024, Volume and Issue: 20(1)

Published: Nov. 28, 2024

Animals exhibit a wide range of social behaviors, including positive actions that promote cohesion and negative behaviors associated with asserting dominance. While these are often viewed as opposites, they can also exist independently or coexist in complex ways, necessitating further investigation into their interrelationships. To study the interplay between two types we examined mouse using resident-intruder assays revealed correlation aggression prosocial allogrooming. Suppressing aggressive motivation through various manipulations, subordination, olfaction ablation, inhibition neural circuits, led to an increased display allogrooming behavior. The findings prompted us explore relationship preschool children. Similarly, observed association which were potentially influenced by inhibitory control abilities. Through this cross-species study, uncovered impact circuits on established link These insights offer valuable implications for understanding influencing interactions both animal human contexts, potential applications education practices.

Language: Английский