Licking microstructure in response to novel rewards, reward devaluation and dopamine antagonists: possible role of D1 and D2 medium spiny neurons in the nucleus accumbens DOI Creative Commons
Paolo S. D’Aquila

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 165, P. 105861 - 105861

Published: Aug. 17, 2024

Evidence on the effect of dopamine D1 and D2-like antagonists manipulations reward value licking microstructure is reanalysed considering recent findings role nucleus accumbens (NAc) medium spiny neurons (MSNs) in control sugar intake. The results this analysis suggest that MSN activation, which involved emission bursts, might play a crucial response to novel rewards. D2 reduction burst size suppression licking, mediate devaluation. Elucidating neural mechanisms underlying lead better definition its microstructural measures behaviourally psychologically meaningful functional terms. This could further support use as behavioural substrate study ingestive behaviour motivation, well animal models pathological conditions such eating disorders obesity.

Language: Английский

Cannabidiol interactions with oxycodone analgesia in an operant orofacial cutaneous thermal pain assay following oral administration in rats DOI
Ariana C. Brice‐Tutt, Niall Murphy, Barry Setlow

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 250, P. 173968 - 173968

Published: Feb. 4, 2025

Language: Английский

Citations

0
Licking microstructure in response to novel rewards, reward devaluation and dopamine antagonists: possible role of D1 and D2 medium spiny neurons in the nucleus accumbens DOI Creative Commons
Paolo S. D’Aquila

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 165, P. 105861 - 105861

Published: Aug. 17, 2024

Evidence on the effect of dopamine D1 and D2-like antagonists manipulations reward value licking microstructure is reanalysed considering recent findings role nucleus accumbens (NAc) medium spiny neurons (MSNs) in control sugar intake. The results this analysis suggest that MSN activation, which involved emission bursts, might play a crucial response to novel rewards. D2 reduction burst size suppression licking, mediate devaluation. Elucidating neural mechanisms underlying lead better definition its microstructural measures behaviourally psychologically meaningful functional terms. This could further support use as behavioural substrate study ingestive behaviour motivation, well animal models pathological conditions such eating disorders obesity.

Language: Английский

Citations

1