Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data DOI Creative Commons
Xin Cheng, Dan Ma, Xiuhong Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Abstract Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on causal relationship between dietary preferences and EM are limited. The present study aimed to explore relationships 187 using Mendelian randomization (MR) methods. This utilised genome-wide association data from over 500,000 European participants for 64,658 patients Finland. with potential were identified two-sample MR P-values inverse variance weighted (IVW) analysis corrected false discovery rate (FDR) method ensure accuracy. Additionally, heterogeneity analysis, pleiotropy assessment, leave-one-out reverse conducted further validate solidify findings study. After FDR correction, IVW revealed that asparagus preference was significantly protective against EM, including American Society Reproductive Medicine (ASRM) stages 1–2 3–4. Conversely, different types coffee orange juice associated an increased likelihood across these stages. Subgroup indicated had a effect deep ovarian pelvic peritoneal rectovaginal septum vaginal EM. In contrast, risk fallopian tube unspecified whereas Reverse did not identify specific analysed this These suggest reduces developing may increase risk, offering new insights into management through modifications.

Language: Английский

Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data DOI Creative Commons
Xin Cheng, Dan Ma, Xiuhong Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Abstract Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on causal relationship between dietary preferences and EM are limited. The present study aimed to explore relationships 187 using Mendelian randomization (MR) methods. This utilised genome-wide association data from over 500,000 European participants for 64,658 patients Finland. with potential were identified two-sample MR P-values inverse variance weighted (IVW) analysis corrected false discovery rate (FDR) method ensure accuracy. Additionally, heterogeneity analysis, pleiotropy assessment, leave-one-out reverse conducted further validate solidify findings study. After FDR correction, IVW revealed that asparagus preference was significantly protective against EM, including American Society Reproductive Medicine (ASRM) stages 1–2 3–4. Conversely, different types coffee orange juice associated an increased likelihood across these stages. Subgroup indicated had a effect deep ovarian pelvic peritoneal rectovaginal septum vaginal EM. In contrast, risk fallopian tube unspecified whereas Reverse did not identify specific analysed this These suggest reduces developing may increase risk, offering new insights into management through modifications.

Language: Английский

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