Spatial multi-omics analysis of the microenvironment in traumatic spinal cord injury: a narrative review DOI Creative Commons

Run Peng,

Liang Zhang, Yongqi Xie

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

Traumatic spinal cord injury (tSCI) is a severe to the central nervous system that categorized into primary and secondary injuries. Among them, local microenvironmental imbalance in caused by includes accumulation of cytokines chemokines, reduced angiogenesis, dysregulation cellular energy metabolism, dysfunction immune cells at site injury, which severely impedes neurological recovery from (SCI). In recent years, single-cell techniques have revealed heterogeneity multiple genomic, transcriptomic, proteomic, metabolomic levels after tSCI, further deepening our understanding mechanisms underlying tSCI. However, spatial information about tSCI microenvironment, such as cell location cell-cell interactions, lost these approaches. The application multi-omics technology can solve this problem combining data obtained immunohistochemistry multiparametric analysis reveal changes microenvironment different times SCI. review, we systematically review progress study SCI, including discuss potential future therapeutic strategies.

Language: Английский

To image or not to image: Use of imaging mass spectrometry in biomedical lipidomics DOI
Albert Maimó-Barceló, Karim Pérez-Romero, Ramón María Alvargonzález Rodríguez

et al.

Progress in Lipid Research, Journal Year: 2025, Volume and Issue: 97, P. 101319 - 101319

Published: Jan. 1, 2025

Language: Английский

Citations

0
Spatial multi-omics analysis of the microenvironment in traumatic spinal cord injury: a narrative review DOI Creative Commons

Run Peng,

Liang Zhang, Yongqi Xie

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

Traumatic spinal cord injury (tSCI) is a severe to the central nervous system that categorized into primary and secondary injuries. Among them, local microenvironmental imbalance in caused by includes accumulation of cytokines chemokines, reduced angiogenesis, dysregulation cellular energy metabolism, dysfunction immune cells at site injury, which severely impedes neurological recovery from (SCI). In recent years, single-cell techniques have revealed heterogeneity multiple genomic, transcriptomic, proteomic, metabolomic levels after tSCI, further deepening our understanding mechanisms underlying tSCI. However, spatial information about tSCI microenvironment, such as cell location cell-cell interactions, lost these approaches. The application multi-omics technology can solve this problem combining data obtained immunohistochemistry multiparametric analysis reveal changes microenvironment different times SCI. review, we systematically review progress study SCI, including discuss potential future therapeutic strategies.

Language: Английский

Citations

2