A Neuroimmune‐Oncology Microphysiological Analysis Platform (NEO‐MAP) for Evaluating Astrocytic Scar Formation and Microgliosis in Glioblastoma Microenvironment DOI Open Access
Yen N. Diep,

Hee Jung Park,

Xiaohui Zhu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by its heterogeneity in cellular components, including reactive astrocytes and microglia. Since neuroimmune responses like astrogliosis microgliosis gain recognition as vital factors tumor progression, there a growing need for clinically relevant models that assess interactions between astrocytes, microglia, GBM. Here, NEuroimmune‐Oncology Microphysiological Analysis Platform (NEO‐MAP) presented “new map” to observe astrocytic scar formation response NEO‐MAP based on pathophysiological principles designed replicate GBM‐glia interactions, multi‐phenotypic microglia activities, scar‐forming with chondroitin sulfate proteoglycans (CSPGs) extracellular matrix, biophysical characteristics barrier. The reveals inhibiting mTORC2 GBM promotes proinflammatory transformation enhanced formation. Astrocytes form scars prompted change from M2 M1 phenotype, enhancing chemotherapy sensitivity. Tissues patients show significant correlation reduced activity increased astrogliosis, alongside decrease M2‐polarized microgliosis, aligning findings. Overall, foreseen tool exploring tumor‐glia opening avenues drug development aimed at microenvironment.

Language: Английский

A Neuroimmune‐Oncology Microphysiological Analysis Platform (NEO‐MAP) for Evaluating Astrocytic Scar Formation and Microgliosis in Glioblastoma Microenvironment DOI Open Access
Yen N. Diep,

Hee Jung Park,

Xiaohui Zhu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by its heterogeneity in cellular components, including reactive astrocytes and microglia. Since neuroimmune responses like astrogliosis microgliosis gain recognition as vital factors tumor progression, there a growing need for clinically relevant models that assess interactions between astrocytes, microglia, GBM. Here, NEuroimmune‐Oncology Microphysiological Analysis Platform (NEO‐MAP) presented “new map” to observe astrocytic scar formation response NEO‐MAP based on pathophysiological principles designed replicate GBM‐glia interactions, multi‐phenotypic microglia activities, scar‐forming with chondroitin sulfate proteoglycans (CSPGs) extracellular matrix, biophysical characteristics barrier. The reveals inhibiting mTORC2 GBM promotes proinflammatory transformation enhanced formation. Astrocytes form scars prompted change from M2 M1 phenotype, enhancing chemotherapy sensitivity. Tissues patients show significant correlation reduced activity increased astrogliosis, alongside decrease M2‐polarized microgliosis, aligning findings. Overall, foreseen tool exploring tumor‐glia opening avenues drug development aimed at microenvironment.

Language: Английский

Citations

0