Clock gene Bmal1 influences the cell cycle of chondrocytes in osteoarthritis DOI
Chunsheng Yang, Mi Chen,

Zulifeiya Aletengbieke

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Abstract Osteoarthritis (OA) is a degenerative disease caused by multiple factors. This study used in vitro and animal models to investigate the connection between biological clock cell cycle osteoarthritic cartilage. The results indicate that transcription levels of circadian gene Bmal1 exhibit negative correlation with Mmp13 positive Wee1. Thus, increased expression Wee1 may be potential protective factor osteoarthritis, while high Per1, Cdk1, Ccnb1, risk factor. By controlling contributing pathophysiology OA, impact apoptosis chondrocytes.

Language: Английский

Clock gene Bmal1 influences the cell cycle of chondrocytes in osteoarthritis DOI
Chunsheng Yang, Mi Chen,

Zulifeiya Aletengbieke

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Abstract Osteoarthritis (OA) is a degenerative disease caused by multiple factors. This study used in vitro and animal models to investigate the connection between biological clock cell cycle osteoarthritic cartilage. The results indicate that transcription levels of circadian gene Bmal1 exhibit negative correlation with Mmp13 positive Wee1. Thus, increased expression Wee1 may be potential protective factor osteoarthritis, while high Per1, Cdk1, Ccnb1, risk factor. By controlling contributing pathophysiology OA, impact apoptosis chondrocytes.

Language: Английский

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