Genotoxicity of Microplastics on Living Organisms: Effects on Chromosomes, DNA and Gene Expression

Environments, Journal Year: 2025, Volume and Issue: 12(1), P. 10 - 10

Published: Jan. 3, 2025

Microplastic exposure has become unavoidable, leading to their presence in living organisms. One area of particular concern is the genotoxicity microplastics, which implications for reproductive health and cancer development. This review aims highlight genotoxic effects microplastics on different organisms, focusing impacts chromosomes, DNA, gene expression. More than 85 papers, primarily published last five years, have been reviewed. indicates that can cause clastogenesis aneugenesis at chromosome level. Clastogenesis results damage, while leads failures segregation without causing direct damage. Additionally, fracture damage DNA. These arise from (1) through interactions with associated proteins; (2) indirect due production reactive oxygen species (ROS) by oxidative stress induced microplastics. Microplastics trigger activation genes related inflammatory response, increased ROS production. Furthermore, they may alter expression other biological processes. The linked stem particles themselves chemicals, it appears be both size- dose-dependent.

Language: Английский

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Environmental Microplastics as Vectors of Non-Polar Organic Pollutants in Drinking Water

Environments, Journal Year: 2025, Volume and Issue: 12(3), P. 81 - 81

Published: March 4, 2025

Microplastics (MPs) in drinking water (DW) raise concerns about their potential impacts on health. Several substances, such as plasticizers and stabilizers, can be leached from plastic polymers following abiotic biotic denaturation processes. Furthermore, the purification treatment of DW, chlorination process, significantly increases release chemical components that are part polymer composition. Recently, several studies reported MPs adsorb environmental xenobiotics, organic molecules heavy metals, thanks to surface characteristics acquired environment which they dispersed. This study aims evaluate ability different sizes (5 µm 1 µm) oxidized by UVB exposure water-dispersed pollutants benzo-a-pyrene (BaP). We used Fourier transform infrared spectroscopy Ζ-potential measurements characterize particles after gas chromatography-mass spectrometry determine adsorptive capacity MPs. The analytical results obtained present demonstrate have a significant BaP dispersed aqueous act vehicle for apolar substances concentrating them. raises an alert dual risk determined consumption DW concentrate convey addition deciding adverse effects related chemical-physical properties.

Language: Английский

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Microplastics as benzo-a-pyrene carriers: genotoxicity assessment simulating human gastric digestion

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Microplastic particles (MPs) are ubiquitous environmental pollutants that can remain in ecosystems for prolonged periods. Plastic materials undergo various degradation processes driven by chemical, physical, and biological factors alter their size, shape, composition, bioavailability. The gastrointestinal tract is the primary pathway through which MPs absorbed, raising concerns as they transport harmful microorganisms into body. Despite widespread presence, effects of exposure to vehicle toxins still not well understood. In this study, we rigorously simulated photoaging polystyrene two distinct sizes (1 µm 5 µm) confirmed capacity adsorb benzo[a]pyrene, a known carcinogen. Moreover, explored capabilities these analyzed genotoxic on liver cells under gastric digestion conditions. Our findings reveal enriched with BaP release toxic compound when ingested exposed juices, markedly increasing toxicity compared individual components. This research underscores alarming potential exacerbate risks associated human health.

Language: Английский

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Guardians under Siege: Exploring Pollution’s Effects on Human Immunity

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7788 - 7788

Published: July 16, 2024

Chemical pollution poses a significant threat to human health, with detrimental effects on various physiological systems, including the respiratory, cardiovascular, mental, and perinatal domains. While impact of these systems has been extensively studied, intricate relationship between chemical immunity remains critical area investigation. The focus this study is elucidate immunity. To accomplish task, presents comprehensive review that encompasses in vitro, ex vivo, vivo studies, shedding light ways which can modulate Our aim unveil complex mechanisms by environmental contaminants compromise delicate balance body's defense going beyond well-established associations delving into less-explored link exposure immune disorders, adding urgency our understanding underlying their implications for public health.

Language: Английский

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Addressing the plastisphere: Sustainable approaches to combat plastic pollution

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 959, P. 178105 - 178105

Published: Dec. 28, 2024

Language: Английский

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