Optimatrix V2.0: Optimised Protocol to Mitigate Microbial Blooms in the Micro-Matrix Bioreactor Platform Used as an Ex Vivo Human Distal Colon Model DOI
Arghya Mukherjee, Nicola Ferremi Leali, Elisa Salvetti

et al.

Published: Jan. 1, 2024

Language: Английский

Thickened feeds for infants with critical CHD: a survey of current practices DOI

Courtney E. Jones,

Hema Desai,

Susan Willette

et al.

Cardiology in the Young, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: March 13, 2025

Abstract Introduction: Dysphagia is common in infants born with critical CHD. Thickened liquids are often used to treat dysphagia, but associated risks limit widespread use among feeding specialists. This survey aims assess dysphagia treatment patterns and thickened liquid across paediatric cardiac surgical centres. Methods: A 24-question, cross-sectional survey. Convenience snowball sampling methods were engage 52 centres affiliated the Cardiac Newborn Neuroprotective Network. Descriptive statistics analyse compare responses. Results: Twenty-six individual respondents represented 21 unique Most responses from experienced, speech–language pathologists (78%) at medium size (88%). Ninety-three percent of responding 81% only after formal instrumental assessment swallowing. oral was for single-ventricle patients by 85% versus 69% two-ventricle patients. Barriers recommending feedings included cost thickening agents, parental non-adherence, gastrointestinal concerns. Conclusions: first report multi-institutional practice variation United States congenital frequently high-risk CHD benefit remains unclear. highlights a broad scientific community poised direct research address variation, short- long-term impact on outcomes, barriers access agents.

Language: Английский

Citations

0

Rebuttal to Gut Microbiome in Children with Congenital Heart Disease After Cardiopulmonary Bypass Surgery (GuMiBear Study) DOI
Catherine Stanton, Fatma Koç, Seán T. Kelleher

et al.

Pediatric Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

0

OPTIMATRIX v2.0: optimised protocol to mitigate microbial blooms in the micro-Matrix bioreactor platform used as an ex vivo human distal colon model. DOI Creative Commons
Arghya Mukherjee, Nicola Ferremi Leali, Elisa Salvetti

et al.

MethodsX, Journal Year: 2025, Volume and Issue: unknown, P. 103275 - 103275

Published: March 1, 2025

We previously reported optimisation of the methodology to mitigate Escherichia coli blooms and associated loss microbial diversity when using micro-Matrix bioreactor platform as an ex vivo model human distal colon. Here, we provide further critical insights that have gained in this regard through follow-up experiments. tested four separate faecal fermentation media compositions for purposes such colon experiments found composition described by MacFarlane et al. is most suitable mitigating blooms, concurrently, maintaining diversity. also if pooled or individual donor samples were more performed better terms gut microbiota batch culture system. Finally, determined prolonged experiments, i.e. durations up 96 h, may be warranted with a view affording particularly fastidious microbes opportunity grow compete their less counterparts. Essentially, into:•Optimal minimise preserve experiments•Optimal inoculum source duration

Language: Английский

Citations

0

Gut Microbiome in Children with Congenital Heart Disease After Cardiopulmonary Bypass Surgery (GuMiBear Study) DOI

Shahida Bibi,

Kanwal Majeed,

Zarmeen Rukhman

et al.

Pediatric Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Language: Английский

Citations

0

Response to “Gut Microbiome in Children with Congenital Heart Disease after Cardiopulmonary Bypass Surgery (GuMiBear Study)” DOI

Fnu Venjhraj,

Ajeet Singh,

Muzna Murtaza

et al.

Pediatric Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 6, 2024

Language: Английский

Citations

0

Optimatrix V2.0: Optimised Protocol to Mitigate Microbial Blooms in the Micro-Matrix Bioreactor Platform Used as an Ex Vivo Human Distal Colon Model DOI
Arghya Mukherjee, Nicola Ferremi Leali, Elisa Salvetti

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0