Causal relationship between immune cells, metabolites and polycystic ovary syndrome identified by Mendelian randomization and mediation analyses

Immunology and Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Immune cells and blood metabolites play essential roles in the development of polycystic ovary syndrome (PCOS); however, it remains unclear whether mediate causal relationship between immune PCOS. This study aimed to delineate relationships among cells, PCOS potential through Mendelian randomization (MR). A two-sample MR analysis was conducted using inverse variance weighting as primary method determine causation risk. supplemented by a two-step assess mediating role In addition, series sensitivity methods were employed test robustness results. We also performed reverse evaluate possibility relationships. Our findings identified 22 cell phenotypes causally linked PCOS, with 12 acting risk factors 10 protective for Furthermore, 45 or ratios related Mediation revealed that X-25519 levels mediated 9.2% absolute count CD28-CD25++ CD8br N-acetylglucosamine/n-acetylgalactosamine adenosine 5'-monophosphate 6.7% -11.1%, respectively, naive DN(CD4- CD8-) %T The aspartate-to-citrate ratio 8.6% CD20- CD38- %B Finally, studies did not identify any elucidates links highlighting four interaction thus providing new targets research therapeutic interventions.

Language: Английский

ChIP-seq and RNA-seq Reveal the Involvement of Histone Lactylation Modification in Early Pregnancy with Subclinical Hypothyroidism

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Language: Английский