Marine natural products

Natural Product Reports, Journal Year: 2015, Volume and Issue: 32(2), P. 116 - 211

Published: Jan. 1, 2015

This review of marine natural products for 2013 describes 1137 new compounds and reports structural revisions assignments absolute configurations previously described compounds. Included is a report the anticancer sponge metabolite PM060184 that has undergone remarkably rapid development from discovery in 2005 to commencement phase I clinical trials 2011.

Language: Английский

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Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products

Marine Drugs, Journal Year: 2019, Volume and Issue: 17(5), P. 249 - 249

Published: April 26, 2019

Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare represent a rather untapped source of chemically diverse secondary metabolites novel bioactive compounds. In this review, we aim to summarize present on isolation, natural product discovery reported from mid-2013 2017. A total 97 new species, representing 9 genera belonging 27 families have been reported, with highest numbers isolates Pseudonocardiaceae, Demequinaceae, Micromonosporaceae Nocardioidaceae. Additionally, study reviewed 167 compounds produced by 58 different actinomycete species 24 genera. Most antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The products were derived Nocardiopsis, Micromonospora, Salinispora Pseudonocardia. Members genus Micromonospora revealed be richest unique products.

Language: Английский

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Promising bioactive compounds from the marine environment and their potential effects on various diseases

Journal of Genetic Engineering and Biotechnology, Journal Year: 2022, Volume and Issue: 20(1), P. 14 - 14

Published: Jan. 26, 2022

The marine environment hosts a wide variety of species that have evolved to live in harsh and challenging conditions. Marine organisms are the focus interest due their capacity produce biotechnologically useful compounds. They promising biocatalysts for new sustainable industrial processes because resistance temperature, pH, salt, contaminants, representing an opportunity several biotechnological applications. Encouraged by extensive richness environment, organisms’ role developing therapeutic benefits is heading as arable field. There currently much biologically active compounds derived from natural resources, especially can efficiently act on molecular targets, which involved various diseases. Studies focused bacteria fungi, isolated sediments, seawater, fish, algae, most invertebrates such sponges, mollusks, tunicates, coelenterates, crustaceans. In addition macro-organisms, or corals, fungi been shown novel secondary metabolites (SMs) with specific intricate chemical structures may hold key production drugs leads. known rich source numerous beneficial health effects. Presently, lines studies provided insight into biological activities neuroprotective effects including antioxidant, anti-neuroinflammatory, cholinesterase inhibitory activity, neuronal death inhibition. application marine-derived bioactive has gained importance uses products (MNPs) display pharmaceutically significant bioactivities, antibiotic, antiviral, neurodegenerative, anticancer, anti-inflammatory properties. present review focuses critical different diseases highlights possible contribution humanity.

Language: Английский

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Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens

3 Biotech, Journal Year: 2017, Volume and Issue: 7(3)

Published: June 29, 2017

Language: Английский

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Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches

Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 9

Published: Aug. 8, 2018

Actinobacteria are wide spread in nature and represent the largest taxonomic group within domain Bacteria. They abundant soil have been extensively explored for their therapeutic applications. This versatile of bacteria has adapted to diverse ecological habitats, which drawn considerable attention scientific community recent times as it opened up new possibilities novel metabolites that may help solving some most challenging problems day, example, drugs drug-resistant human pathogens, affordable means maintain balance various habitats alternative practices sustainable agriculture. Traditionally, free dwelling actinobacteria subject intensive research. Of late, symbiotic residing endophytes plant tissues generated immense interest potential source compounds, find applications medicine, agriculture environment. In light these possibilities, this review focuses on diversity endophytic isolated from plants extreme specific niches. Furthermore, an attempt made assign chemical class compounds obtained actinobacteria. Potential utility environment discussed.

Language: Английский

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The Essentials of Marine Biotechnology

Frontiers in Marine Science, Journal Year: 2021, Volume and Issue: 8

Published: March 16, 2021

Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well tried to support new economic endeavors (ocean energy, desalination for water supply, seabed mining). Modern societies lifestyle resulted in an increased demand dietary diversity, better health well-being, biomedicines, natural cosmeceuticals, environmental conservation, sustainable energy sources. These societal needs stimulated interest of researchers diverse underexplored environments promising sources biomolecules biomass, they are addressed by emerging field (blue) biotechnology. Blue biotechnology provides opportunities a wide range initiatives commercial pharmaceutical, biomedical, cosmetic, nutraceutical, feed, agricultural, related industries. This article synthesizes essence, opportunities, responsibilities, challenges encountered outlines attainment valorization directly derived or bio-inspired products from organisms. First, concept bioeconomy is introduced. Then, diversity bioresources including overview most prominent organisms their potential biotechnological uses described. followed introducing methodologies exploration these main use case scenarios food agronomy, bioremediation climate change, materials, healthcare, well-being sectors. The key aspects fields legislation funding provided, with emphasis importance communication stakeholder engagement at all levels development. Finally, vital overarching concepts, such quadruple helix Responsible Research Innovation principle highlighted important follow within field. authors this review collaborating under European Commission-funded Cooperation Science Technology (COST) Action Ocean4Biotech – transdisciplinary networking platform focus study state affairs.

Language: Английский

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Bioactive Metabolites from Terrestrial and Marine Actinomycetes

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5915 - 5915

Published: Aug. 6, 2023

Actinomycetes inhabit both terrestrial and marine ecosystems are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, antiviral activities. In this review, we delve into the life cycle, ecology, taxonomy, classification actinomycetes, as well their varied bioactive metabolites recently discovered between 2015 2023. Additionally, explore promising strategies to unveil investigate new metabolites, encompassing genome mining, activation silent genes through signal molecules, co-cultivation approaches. By presenting comprehensive up-to-date hope offer potential solution uncover novel compounds essential

Language: Английский

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Concepts and Methods to Access Novel Antibiotics from Actinomycetes

Antibiotics, Journal Year: 2018, Volume and Issue: 7(2), P. 44 - 44

Published: May 22, 2018

Actinomycetes have been proven to be an excellent source of secondary metabolites for more than half a century. Exhibiting various bioactivities, they provide valuable approved drugs in clinical use. Most microorganisms are still untapped terms their capacity produce metabolites, since only small fraction can cultured the laboratory. Thus, improving cultivation techniques extend range metabolite producers accessible under laboratory conditions is important first step prospecting underexplored sources isolation novel antibiotics. Currently uncultured actinobacteria made available by bioprospecting extreme or simply habitats other soil. Furthermore, bioinformatic analysis genomes reveals most harbour many biosynthetic gene clusters compounds identified from any single strain, which translates into silent potential microbial world production yet unknown natural products. This review covers discovery strategies and innovative methods recently employed access reservoir The focus order actinomycetes although approaches similarly applicable microbes. Advanced methods, genomics- metagenomics-based approaches, as well modern metabolomics-inspired highlighted emphasise interplay different disciplines improve

Language: Английский

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Nocardiopsis species: Incidence, ecological roles and adaptations

Microbiological Research, Journal Year: 2015, Volume and Issue: 174, P. 33 - 47

Published: April 6, 2015

Language: Английский

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Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds

Frontiers in Microbiology, Journal Year: 2017, Volume and Issue: 8

Published: June 15, 2017

Actinobacteria are prolific producers of thousands biologically active natural compounds with diverse activities. More than half these bioactive have been isolated from members belonging to actinobacteria. Recently, rare actinobacteria existing at different environmental settings such as high altitudes, volcanic areas, and marine environment attracted attention. It has speculated that physiological or biochemical pressures under harsh conditions can lead the production diversified compounds. Hence, focused for discovery novel products biological potency. Many promising versatile medicinal, industrial, agricultural uses characterized. The cannot be directly used drug other purposes, so they structurally modified ameliorate their chemical properties. Versatile synthetic tools, metabolic engineering techniques, synthesis platform assist structural modification. This review summarizes latest studies on focus recent approaches functional diversification microbial chemicals attaining better applications.

Language: Английский

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