The artificial sweetener erythritol and cardiovascular event risk

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(3), P. 710 - 718

Published: Feb. 27, 2023

Language: Английский

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Erythritol: An In-Depth Discussion of Its Potential to Be a Beneficial Dietary Component

Nutrients, Journal Year: 2023, Volume and Issue: 15(1), P. 204 - 204

Published: Jan. 1, 2023

The sugar alcohol erythritol is a relatively new food ingredient. It naturally occurring in plants, however, produced commercially by fermentation. also endogenously via the pentose phosphate pathway (PPP). Consumers perceive as less healthy than sweeteners extracted from including sucrose. This review evaluates that perspective summarizing current literature regarding erythritol's safety, production, metabolism, and health effects. Dietary 30% sweet sucrose, but contains negligible energy. Because it almost fully absorbed excreted urine, better tolerated other alcohols. Evidence shows has potential beneficial replacement for diabetic subjects exerts no effects on glucose or insulin induces gut hormone secretions modulate satiety to promote weight loss. Long-term rodent studies show consumption lowers body adiposity. However, observational indicate positive association between plasma obesity cardiometabolic disease. unlikely dietary mediating these associations, rather they reflect dysregulated PPP due impaired glycemia glucose-rich diet. long-term clinical trials investigating of chronic risk metabolic diseases are needed. Current evidence suggests will document compared caloric sugars allay consumer misperceptions.

Language: Английский

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Cell type-specific regulation of the pentose phoshate pathway during development and metabolic stress-driven autoimmune diseases: Relevance for inflammatory liver, renal, endocrine, cardiovascular and neurobehavioral comorbidites, carcinogenesis, and aging

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(5), P. 103781 - 103781

Published: Feb. 24, 2025

Language: Английский

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Recent advances in biological production of sugar alcohols

Current Opinion in Biotechnology, Journal Year: 2015, Volume and Issue: 37, P. 105 - 113

Published: Dec. 23, 2015

Language: Английский

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Recent advances in the biotechnological production of erythritol and mannitol

Critical Reviews in Biotechnology, Journal Year: 2020, Volume and Issue: 40(5), P. 608 - 622

Published: April 16, 2020

Dietary habits that include an excess of added sugars have been strongly associated with increased risk obesity, heart disease, diabetes, and tooth decay. With this association in view, modern food systems aim to replace low calorie sweeteners, such as polyols. Polyols are generally not carcinogenic do trigger a glycemic response. Furthermore, owing the absence carbonyl group, they more stable compared monosaccharides participate Maillard reactions. As such, since polyols at high temperatures, brown or caramelize when heated. Therefore, widely used diets hypocaloric diabetic patients, well other specific cases where controlled caloric intake is required. In recent years, erythritol mannitol gained importance, especially pharmaceutical industries. these areas, research efforts made improve productivity yield two polyols, relying on biotechnological manufacturing methods. The present review highlights advances production summarizes benefits using

Language: Английский

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The effects of sugar alcohols on rheological properties, functionalities, and texture in baked products – A review

Trends in Food Science & Technology, Journal Year: 2021, Volume and Issue: 111, P. 670 - 679

Published: March 18, 2021

Language: Английский

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Suitability of Sugar Alcohols as Antidiabetic Supplements: A Review

Journal of Food and Drug Analysis, Journal Year: 2021, Volume and Issue: 29(1), P. 1 - 14

Published: March 15, 2021

The major goals in the management of diabetes are to maintain normal control glucose metabolism and glycemia. Dietary modification is one most recommended treatment modalities for diabetic patients. use foods sweetened with sugar alcohols (also known as polyols) such xylitol, sorbitol, mannitol, maltitol, lactitol, isomalt erythritol, has brought an escalating interest. Since some do not raise plasma glucose, they partially digested metabolised. Diet composition adequacy may be altered by replacing carbohydrates alcohols. It been established that these polyols appropriate substitutes a healthy lifestyle foods. present review focuses on evidence supporting diabetes, evaluating their physical chemical properties, metabolism, absorption, glycemic insulinemic control. Although documentation glycaemic response evident compounds antidiabetic, there however dearth literature possible toxicity and/or side effects associated usage at or abusive doses. Thus, future studies should also focus order define safety.

Language: Английский

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Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

Microorganisms, Journal Year: 2020, Volume and Issue: 8(4), P. 574 - 574

Published: April 15, 2020

Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply applications in agro-food, chemical pharmaceutical industries. The main challenge their production is to reach productivity threshold allow process be profitable. This relies on construction efficient cell factories by metabolic engineering development low-cost processes using industrial wastes or cheap widely available raw materials as feedstock. non-conventional yeast Yarrowia lipolytica has emerged recently potential producer such metabolites owing its low nutritive requirements, ability grow at high densities bioreactor ease genome edition. review will focus current knowledge synthesis most important sugar Y. lipolytica.

Language: Английский

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Production of plant metabolites with applications in the food industry using engineered microorganisms

Current Opinion in Biotechnology, Journal Year: 2018, Volume and Issue: 56, P. 7 - 17

Published: Aug. 13, 2018

Language: Английский

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Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering

Microbial Cell Factories, Journal Year: 2018, Volume and Issue: 17(1)

Published: Aug. 29, 2018

Erythritol is a four-carbon sugar alcohol with sweetening properties that used by the agro-food industry as food additive. In yeast Yarrowia lipolytica, last step of erythritol synthesis involves reduction erythrose specific reductase(s). earlier report, an reductase gene (YALI0F18590g) from erythritol-producing Y. lipolytica MK1 was identified (Janek et al. in Microb Cell Fact 16:118, 2017). However, deletion only resulted some lower production but process still maintained, indicating other gene(s) might exist genome lipolytica.In this study, we have isolated genes g141.t1 (YALI0D07634g) and g3023.t1 (YALI0C13508g) encoding two novel reductases (ER). The biochemical characterization purified enzymes showed they strong affinity for erythrose. Deletion ER plus g801.t1 did not prevent synthesis, suggesting or ER-like remain to be discovered yeast. Overexpression newly (ER10 ER25) led average 14.7% higher yield 31.2% productivity compared wild-type strain. Finally, engineering NADPH cofactor metabolism overexpression ZWF1 GND1 glucose-6-phosphate dehydrogenase 6-phosphogluconate dehydrogenase, respectively, allowed 23.5% 50% best our constructed strains produced titer 190 g/L baffled flasks using glucose main carbon source.Our results highlight several encode able reduce into erythritol. catalytic these their dependency are different already known lipolytica. Constitutive expression increase titer. Development fermentation strategies will allow further improvement future.

Language: Английский

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