Bioprocess and Biosystems Engineering, Journal Year: 2023, Volume and Issue: 46(9), P. 1351 - 1363
Published: July 19, 2023
Language: Английский
Bioprocess and Biosystems Engineering, Journal Year: 2023, Volume and Issue: 46(9), P. 1351 - 1363
Published: July 19, 2023
Language: Английский
Nature Medicine, Journal Year: 2023, Volume and Issue: 29(3), P. 710 - 718
Published: Feb. 27, 2023
Language: Английский
Citations
129Nutrients, Journal Year: 2023, Volume and Issue: 15(1), P. 204 - 204
Published: Jan. 1, 2023
The sugar alcohol erythritol is a relatively new food ingredient. It naturally occurring in plants, however, produced commercially by fermentation. also endogenously via the pentose phosphate pathway (PPP). Consumers perceive as less healthy than sweeteners extracted from including sucrose. This review evaluates that perspective summarizing current literature regarding erythritol's safety, production, metabolism, and health effects. Dietary 30% sweet sucrose, but contains negligible energy. Because it almost fully absorbed excreted urine, better tolerated other alcohols. Evidence shows has potential beneficial replacement for diabetic subjects exerts no effects on glucose or insulin induces gut hormone secretions modulate satiety to promote weight loss. Long-term rodent studies show consumption lowers body adiposity. However, observational indicate positive association between plasma obesity cardiometabolic disease. unlikely dietary mediating these associations, rather they reflect dysregulated PPP due impaired glycemia glucose-rich diet. long-term clinical trials investigating of chronic risk metabolic diseases are needed. Current evidence suggests will document compared caloric sugars allay consumer misperceptions.
Language: Английский
Citations
51Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(5), P. 103781 - 103781
Published: Feb. 24, 2025
Language: Английский
Citations
2Current Opinion in Biotechnology, Journal Year: 2015, Volume and Issue: 37, P. 105 - 113
Published: Dec. 23, 2015
Language: Английский
Citations
135Critical Reviews in Biotechnology, Journal Year: 2020, Volume and Issue: 40(5), P. 608 - 622
Published: April 16, 2020
Dietary habits that include an excess of added sugars have been strongly associated with increased risk obesity, heart disease, diabetes, and tooth decay. With this association in view, modern food systems aim to replace low calorie sweeteners, such as polyols. Polyols are generally not carcinogenic do trigger a glycemic response. Furthermore, owing the absence carbonyl group, they more stable compared monosaccharides participate Maillard reactions. As such, since polyols at high temperatures, brown or caramelize when heated. Therefore, widely used diets hypocaloric diabetic patients, well other specific cases where controlled caloric intake is required. In recent years, erythritol mannitol gained importance, especially pharmaceutical industries. these areas, research efforts made improve productivity yield two polyols, relying on biotechnological manufacturing methods. The present review highlights advances production summarizes benefits using
Language: Английский
Citations
89Trends in Food Science & Technology, Journal Year: 2021, Volume and Issue: 111, P. 670 - 679
Published: March 18, 2021
Language: Английский
Citations
61Journal of Food and Drug Analysis, Journal Year: 2021, Volume and Issue: 29(1), P. 1 - 14
Published: March 15, 2021
The major goals in the management of diabetes are to maintain normal control glucose metabolism and glycemia. Dietary modification is one most recommended treatment modalities for diabetic patients. use foods sweetened with sugar alcohols (also known as polyols) such xylitol, sorbitol, mannitol, maltitol, lactitol, isomalt erythritol, has brought an escalating interest. Since some do not raise plasma glucose, they partially digested metabolised. Diet composition adequacy may be altered by replacing carbohydrates alcohols. It been established that these polyols appropriate substitutes a healthy lifestyle foods. present review focuses on evidence supporting diabetes, evaluating their physical chemical properties, metabolism, absorption, glycemic insulinemic control. Although documentation glycaemic response evident compounds antidiabetic, there however dearth literature possible toxicity and/or side effects associated usage at or abusive doses. Thus, future studies should also focus order define safety.
Language: Английский
Citations
57Microorganisms, Journal Year: 2020, Volume and Issue: 8(4), P. 574 - 574
Published: April 15, 2020
Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply applications in agro-food, chemical pharmaceutical industries. The main challenge their production is to reach productivity threshold allow process be profitable. This relies on construction efficient cell factories by metabolic engineering development low-cost processes using industrial wastes or cheap widely available raw materials as feedstock. non-conventional yeast Yarrowia lipolytica has emerged recently potential producer such metabolites owing its low nutritive requirements, ability grow at high densities bioreactor ease genome edition. review will focus current knowledge synthesis most important sugar Y. lipolytica.
Language: Английский
Citations
71Current Opinion in Biotechnology, Journal Year: 2018, Volume and Issue: 56, P. 7 - 17
Published: Aug. 13, 2018
Language: Английский
Citations
68Microbial Cell Factories, Journal Year: 2018, Volume and Issue: 17(1)
Published: Aug. 29, 2018
Erythritol is a four-carbon sugar alcohol with sweetening properties that used by the agro-food industry as food additive. In yeast Yarrowia lipolytica, last step of erythritol synthesis involves reduction erythrose specific reductase(s). earlier report, an reductase gene (YALI0F18590g) from erythritol-producing Y. lipolytica MK1 was identified (Janek et al. in Microb Cell Fact 16:118, 2017). However, deletion only resulted some lower production but process still maintained, indicating other gene(s) might exist genome lipolytica.In this study, we have isolated genes g141.t1 (YALI0D07634g) and g3023.t1 (YALI0C13508g) encoding two novel reductases (ER). The biochemical characterization purified enzymes showed they strong affinity for erythrose. Deletion ER plus g801.t1 did not prevent synthesis, suggesting or ER-like remain to be discovered yeast. Overexpression newly (ER10 ER25) led average 14.7% higher yield 31.2% productivity compared wild-type strain. Finally, engineering NADPH cofactor metabolism overexpression ZWF1 GND1 glucose-6-phosphate dehydrogenase 6-phosphogluconate dehydrogenase, respectively, allowed 23.5% 50% best our constructed strains produced titer 190 g/L baffled flasks using glucose main carbon source.Our results highlight several encode able reduce into erythritol. catalytic these their dependency are different already known lipolytica. Constitutive expression increase titer. Development fermentation strategies will allow further improvement future.
Language: Английский
Citations
62