Natural and synthetic molecules with potential to enhance biofilm formation and virulence properties in Pseudomonas aeruginosa

Critical Reviews in Microbiology, Journal Year: 2023, Volume and Issue: 50(5), P. 830 - 858

Published: Nov. 15, 2023

can efficiently adapt to changing environmental conditions due its ubiquitous nature, intrinsic/acquired/adaptive resistance mechanisms, high metabolic versatility, and the production of numerous virulence factors. As a result,

Language: Английский

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Effectiveness of Pseudomonas aeruginosa type VI secretion system relies on toxin potency and type IV pili-dependent interaction

PLoS Pathogens, Journal Year: 2023, Volume and Issue: 19(5), P. e1011428 - e1011428

Published: May 30, 2023

The type VI secretion system (T6SS) is an antibacterial weapon that used by numerous Gram-negative bacteria to gain competitive advantage injecting toxins into adjacent prey cells. Predicting the outcome of a T6SS-dependent competition not only reliant on presence-absence but instead involves multiplicity factors. Pseudomonas aeruginosa possesses 3 distinct T6SSs and set more than 20 toxic effectors with diverse functions including disruption cell wall integrity, degradation nucleic acids or metabolic impairment. We generated comprehensive collection mutants various degrees T6SS activity and/or sensitivity each individual toxin. By imaging whole mixed bacterial macrocolonies, we then investigated how these P. strains edge in multiple attacker/prey combinations. observed potency single toxin varies significantly from one another as measured monitoring community structure, some acting better synergy requiring higher payload. Remarkably degree intermixing between preys attackers also key driven frequency contact well ability move away attacker using IV pili-dependent twitching motility. Finally, implemented computational model understand changes firing behaviours cell-cell contacts lead population level advantages, thus providing conceptual insight applicable all types contact-based competition.

Language: Английский

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Pseudomonas aeruginosa quorum sensing and biofilm attenuation by a di-hydroxy derivative of piperlongumine (PL-18)

Biofilm, Journal Year: 2024, Volume and Issue: 8, P. 100215 - 100215

Published: July 18, 2024

Bacterial communication, Quorum Sensing (QS), is a target against virulence and prevention of antibiotic-resistant infections. 16 derivatives Piperlongumine (PL), an amide alkaloid from Piper longum L., were screened for QS inhibition. PL-18 had the best QSI activity. inhibited lasR-lasI, rhlR-rhlI, pqs systems Pseudomonas aeruginosa. pyocyanin rhamnolipids that are QS-controlled elements. Iron essential element pathogenicity, biofilm formation resilience in harsh environments, its uptake was by PL-18. Pl-18 significantly reduced biovolume including established biofilms. PL-18-coated silicon tubes formation. The transcriptome study treated P. aeruginosa showed indeed expression iron homeostasis related genes, up regulated sulfur metabolism genes. Altogether, inhibits QS, virulence, uptake, Thus, should be further developed bacterial infection, antibiotic resistance,

Language: Английский

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Effect of samarium oxide nanoparticles on virulence factors and motility of multi-drug resistant Pseudomonas aeruginosa

World Journal of Microbiology and Biotechnology, Journal Year: 2022, Volume and Issue: 38(11)

Published: Aug. 30, 2022

Language: Английский

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Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer's Disease

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 120, P. 110290 - 110290

Published: May 20, 2023

Language: Английский

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