Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1562 - 1562
Published: Dec. 6, 2024
Background:
Postoperative
abdominal
adhesion
is
a
prevalent
complication
following
surgery,
with
the
incidence
of
reaching
up
to
90%,
which
may
precipitate
range
adverse
outcomes.
Although
fibrous
membranes
loaded
various
anti-inflammatory
or
other
drugs
have
been
proposed
for
anti-adhesion,
most
them
suffer
from
drug-induced
effects.
Methods:
In
this
study,
lecithin-based
electrospun
polylactic
acid
(PLA)
nanofibrous
membrane
(L/P-NM)
was
developed
prevention
postoperative
adhesion,
utilizing
hydration
lubrication
theory.
The
zwitterionic
lecithin
allows
nanofiber
surface
strongly
bind
water
molecules
create
interface.
Results:
As
TGA
results
show,
content
bound
in
nanofibers
increased
significantly
increase
content.
Tribological
test
show
that
L/P-NM
reached
minimum
coefficient
friction
(COF)
about
0.112.
Additionally,
possess
favorable
tensile
property
and
biocompatibility.
Rat
model
evaluation
demonstrated
possesses
significant
anti-adhesive
performance,
an
score
only
1.
Conclusions:
Therefore,
study
offers
promising
strategy
efficiently
preventing
adhesion.
Frontiers in Materials,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 7, 2025
Bio-based
plastics
represent
an
opportunity
to
reduce
the
impact
of
petroleum-based
on
environment,
leading
harmful
effects
both
terrestrial
and
marine
ecosystems.
Nevertheless,
plant
origin
bio-based
does
not
necessarily
imply
better
management
their
end
life.
However,
when
recycling
is
impossible,
biological
degradation
would
be
effective
method
environmental
impact.
Polylactic
acid
(PLA)
one
most
produced
biopolymers
currently
among
already
developed
for
several
years.
Thus,
objective
this
article
provide
a
state
art
biodegradation
based
PLA.
In
particular,
microorganisms
catalyzing
different
biochemical
reactions
main
mechanisms
are
reviewed
according
aerobic
anaerobic
conditions.
Moreover,
involved
in
PLA
summarized.
Furthermore,
special
attention
paid
analytical
methods
evaluate
polylactic
existing
test
methods,
because
subject
has
rarely
been
literature.
end,
promising
topics
future
research
proposed,
such
as
enzyme
engineering
technology
recently
emerging
new
common
testing
collect
much
data
possible
biodegradability
compare
studies.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(3)
Published: March 1, 2025
ABSTRACT
Spinal
fusion
cages
play
a
crucial
role
in
stabilizing
the
spine
and
promoting
bone
growth
degenerative
disorders.
Recent
advancements
biodegradable
polymer‐based
have
introduced
materials
with
shape
memory
properties,
enabling
minimally
invasive
implantation
improved
adaptability.
This
study
focuses
on
development
of
4D‐printed
PLA/PCL
blend
spinal
cages,
investigating
their
thermal,
mechanical,
biodegradation,
alongside
surface
wettability
through
contact
angle
measurements.
The
novelty
this
lies
identifying
optimal
ratio,
balancing
mechanical
strength,
biodegradability,
behavior
for
applications.
findings
highlight
(80:20)
as
most
suitable
composition,
offering
well‐balanced
combination
properties.
Differential
scanning
calorimetry
(DSC)
analysis
revealed
that
20
wt%
PCL
enhances
toughness,
flexibility,
crystallinity
while
slightly
reducing
glass
transition
temperature.
Mechanical
testing
showed
fracture
elongation
at
tensile
stress
peaking
before
decreasing
higher
concentrations
due
to
increased
ductility.
Biodegradation
studies
confirmed
an
increasing
degradation
rate
content,
measurements
indicated
greater
hydrophilicity,
though
trend
reversed
concentrations.
Shape
demonstrated
content
from
10
60
wt%,
recovery
decreased
76.07%
61.28%,
high
fixity
(96.42%–99.80%)
was
maintained.
PLA/PCL20
exhibited
74.5%
effect
68.75%
cage
design,
making
it
promising
material
Polymers,
Journal Year:
2024,
Volume and Issue:
16(23), P. 3368 - 3368
Published: Nov. 29, 2024
The
integration
of
machine
learning
(ML)
into
material
manufacturing
has
driven
advancements
in
optimizing
biopolymer
production
processes.
ML
techniques,
applied
across
various
stages
production,
enable
the
analysis
complex
data
generated
throughout
identifying
patterns
and
insights
not
easily
observed
through
traditional
methods.
As
sustainable
alternatives
to
petrochemical-based
plastics,
biopolymers
present
unique
challenges
due
their
reliance
on
variable
bio-based
feedstocks
processing
conditions.
This
review
systematically
summarizes
current
applications
techniques
aiming
provide
a
comprehensive
reference
for
future
research
while
highlighting
potential
enhance
efficiency,
reduce
costs,
improve
product
quality.
also
shows
role
algorithms,
including
supervised,
unsupervised,
deep
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Global
plastic
production
is
increasing
yearly,
with
packaging
materials
and
disposable
plastics
accounting
for
a
sizable
portion
of
the
total.
Despite
its
apparent
advantages,
resulting
waste
accumulates
in
landfills
oceans,
causing
severe
environmental
public
health
issues.
Shifting
from
conventional
to
biodegradable
(BPs)
increasingly
being
proposed
as
an
efficient
management
end-of-life
plastics.
While
several
BPs
such
poly(lactic
acid),
poly(ε-caprolactone),
poly(hydroxyalkanoates)
have
been
widely
used,
their
biodegradation
rates
often
do
not
meet
anticipated
level
under
home-compost
or
other
certain
environments
(e.g.,
soil,
marine).
Recently,
enzyme-embedded
emerged
outstanding
alternative
currently
used
synthetic
It
achieves
rapid
degradation
compostability
by
introducing
specific
enzyme
into
polymer.
In
this
context,
review
aims
summarize
recent
advances
development
superior
biomaterials.
identifies
prioritizes
critical
success
factors
required
BPs.
The
also
discusses
challenges
application
these
innovative
polymer
materials.
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(3), P. 278 - 278
Published: March 11, 2025
Age-related
macular
degeneration
(AMD),
a
progressive
neurodegenerative
disorder
affecting
the
central
retina,
is
pathologically
defined
by
irreversible
of
photoreceptors
and
retinal
pigment
epithelium
(RPE),
coupled
with
extracellular
drusen
deposition
choroidal
neovascularization
(CNV),
AMD
constitutes
predominant
etiological
factor
for
vision
impairment
in
adults
aged
≥60
years.
Cell-based
or
cell-biomaterial
scaffold-based
approaches
have
been
popular
recent
years
as
major
research
direction
AMD;
monotherapy
cell-based
typically
involves
subretinal
injection
progenitor-derived
stem
cell-derived
RPE
cells
to
restore
homeostasis.
Meanwhile,
scaffolds
delivered
lesion
site
vector
transplantation
widely
developed,
implanted
can
promote
reintegration
at
solve
problems
translocation
discrete
cellular
structure
produced
cell
injection.
While
these
therapeutic
strategies
demonstrate
preliminary
efficacy,
rigorous
preclinical
validation
clinical
trials
remain
imperative
validate
their
long-term
safety,
functional
durability,
consistency.
This
review
synthesizes
current
advancements
translational
challenges
scaffold
AMD,
aiming
inform
future
development
targeted
interventions
pathogenesis
management.
