Authors’ response to the Letter to the Editor DOI Creative Commons
Lucas N. M. da Silva, Alípio Gomes Ormond Filho, Júlio Brandão Guimarães

et al.

Skeletal Radiology, Journal Year: 2024, Volume and Issue: 53(10), P. 2287 - 2287

Published: Feb. 6, 2024

Language: Английский

The Evaluation of New-Generation Biomarker sCD14ST Provides New Insight into COVID-19’s Effect on Bone Remodeling DOI Open Access
Emanuela Galliera, Luca Massaccesi, Laura Mangiavini

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 979 - 979

Published: Feb. 3, 2025

Background/Objectives: The COVID-19 pandemic has increased interest in osteoimmunology because of the impact SARS-CoV-2 on both immune system and bone microenvironment. Soluble CD14ST could influence production osteoimmunological regulators osteoclast differentiation. aim this study is to evaluate role sCD14ST COVID-19’s effects remodeling—evaluating, particular, correlation with new-generation biomarkers—and acquire comprehensive knowledge disease skeletal system. Methods: serum level was measured COVID-19-positive COVID-19-negative patients undergoing orthopedic surgery correlated inflammatory biomarkers RANKL/OPG, FGF23, IL-6, C-reactive protein (CRP), procalcitonin (PCT), sRAGE, SuPAR. Results: In our patients, showed a strong increase significant decrease tandem infection resolution, confirming its diagnostic prognostic value. more clinically relevant than two canonically makers used clinical protocols, CRP PCT, displayed good positive SuPAR negative sRAGE. Conclusions: Monitoring along may offer valuable insights into dysregulation bone-related complications conditions characterized by inflammation. These soluble receptors represent important links between activation metabolism, especially context diseases like COVID-19, where response fragility.

Language: Английский

Citations

0
The role of NOS3-rs1799983 and NOS3- rs2070744 SNP in occurrence of avascular necrosis as a post COVID-19 complication DOI Creative Commons

Eman Abd Allah Mahmoud Fouda,

Eman Badr,

Doaa Gawesh

et al.

BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: Aug. 21, 2024

Avascular necrosis (AVN) is a debilitating condition characterized by bone tissue death due to inadequate blood supply, leading joint dysfunction and collapse. This study investigates the potential association between AVN COVID-19, focusing on genetic factors such as NOS3 polymorphisms. A total of 180 individuals were included, comprising 120 COVID-19 patients 60 healthy controls. Clinical, haematological, biochemical, parameters assessed. Results revealed significant differences in respiratory heart rates, haematological counts, biochemical markers control groups. Genetic analysis showed higher prevalence TG genotype G allele rs1799983 polymorphism among patients. Additionally, rs2070744 correlated with various clinical parameters, including pressure, rate, indices. highlights role predisposing following infection.

Language: Английский

Citations

2
The musculoskeletal manifestations of SARS-CoV-2 infections/vaccinations are more diverse than expected DOI
Josef Finsterer

Skeletal Radiology, Journal Year: 2024, Volume and Issue: 53(10), P. 2285 - 2286

Published: Feb. 3, 2024

Language: Английский

Citations

0
Authors’ response to the Letter to the Editor DOI Creative Commons
Lucas N. M. da Silva, Alípio Gomes Ormond Filho, Júlio Brandão Guimarães

et al.

Skeletal Radiology, Journal Year: 2024, Volume and Issue: 53(10), P. 2287 - 2287

Published: Feb. 6, 2024

Language: Английский

Citations

0