European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2023, Volume and Issue: 50(11), P. 3166 - 3167
Published: July 22, 2023
Language: Английский
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(10), P. 4084 - 4097
Published: Aug. 22, 2023
Dementia is a leading cause of disability and death worldwide. At present there no disease modifying treatment for any the most common types dementia such as Alzheimer's (AD), Vascular dementia, Lewy Body (LBD) Frontotemporal (FTD). Early accurate diagnosis subtype critical to improving clinical care developing better treatments. Structural molecular imaging has contributed understanding pathophysiology neurodegenerative dementias increasingly being adopted into practice early diagnosis. In this review we summarise contribution made with particular focus on multimodal magnetic resonance (MRI) positron emission tomography (PET). MRI widely used in can help exclude reversible causes memory problems but relatively low sensitivity differential subtypes.
Language: Английский
Citations
60
Cells, Journal Year: 2023, Volume and Issue: 12(5), P. 736 - 736
Published: Feb. 24, 2023
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of upper and lower motor neurons, resulting in progressive weakness all voluntary muscles eventual respiratory failure. Non-motor symptoms, such as cognitive behavioral changes, frequently occur over the course disease. Considering its poor prognosis with median survival time 2 to 4 years limited causal treatment options, an early diagnosis ALS plays essential role. In past, has primarily been determined clinical findings supported electrophysiological laboratory measurements. To increase diagnostic accuracy, reduce delay, optimize stratification trials provide quantitative monitoring progression responsivity, research on disease-specific feasible fluid biomarkers, neurofilaments, intensely pursued. Advances imaging techniques have additionally yielded benefits. Growing perception greater availability genetic testing facilitate identification pathogenic ALS-related gene mutations, predictive access novel therapeutic agents addressing disease-modified therapies before advent first symptoms. Lately, personalized prediction models proposed offer more detailed disclosure for patient. this review, established procedures future directions diagnostics are summarized serve practical guideline improve pathway burdensome
Language: Английский
Citations
26
Expert Review of Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 22, 2025
. There are currently few treatments approved for amyotrophic lateral sclerosis (ALS). Additionally, there remains a significant unmet need reliable, standardized biomarkers to assess endpoints in clinical trials. Magnetic resonance imaging (MRI)- and positron emission tomography (PET)-derived metrics could help patient selection stratification, shortening trial duration reducing costs. This review focuses on the potential use of neuroimaging context ALS therapeutic trials, providing insights structural functional neuroimaging, plexus muscle alterations, glial involvement neuroinflammation, envisioning how these surrogates disease progression be implemented A PubMed search covering past 15 years was performed. Neuroimaging is essential understanding pathophysiology, aiding tracking evaluating interventions. High costs, limited accessibility, lack standardization, tolerability limit their routine care. Addressing obstacles fully harnessing improving diagnostics treatment ALS.
Language: Английский
Citations
1
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(2), P. 158 - 158
Published: Feb. 4, 2024
Astrocytes displaying reactive phenotypes are characterized by their ability to remodel morphologically, molecularly, and functionally in response pathological stimuli. This process results the loss of typical astrocyte functions acquisition neurotoxic or neuroprotective roles. A growing body research indicates that these astrocytes play a pivotal role pathogenesis amyotrophic lateral sclerosis (ALS), involving calcium homeostasis imbalance, mitochondrial dysfunction, abnormal lipid lactate metabolism, glutamate excitotoxicity, etc. review summarizes characteristics astrocytes, ALS, recent advancements astrocyte-targeting strategies.
Language: Английский
Citations
6
Magnetic Resonance Imaging Clinics of North America, Journal Year: 2024, Volume and Issue: 32(2), P. 375 - 384
Published: Feb. 6, 2024
Language: Английский
Citations
6
Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1411 - 1411
Published: July 12, 2023
There is a pressing need for disease-modifying therapies in patients suffering from neurodegenerative diseases, including Parkinson’s disease (PD). However, these disorders face unique challenges clinical trial designs to assess the neuroprotective properties of potential drug candidates. One relates often unknown individual mechanisms that would, however, be relevant targeted treatment strategies. Neuroinflammation and mitochondrial dysfunction are two proposed pathophysiological hallmarks considered highly interconnected PD. Innovative neuroimaging methods can potentially help gain deeper insights into one’s predominant mechanisms, facilitate patient stratification trials, could map responses. This review aims highlight role neuroinflammation with PD (PwPD). We will specifically introduce different modalities, their respective technical hurdles challenges, implementation practice. gather preliminary evidence use research discuss opportunities future trials.
Language: Английский
Citations
11
Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(5), P. 401 - 415
Published: Feb. 1, 2024
Abstract: Depression is one of the key conditions addressed by Mental Health Gap Action Programme (mhGAP) WHO that can lead to self-harm and suicide. associated with low levels neurotransmitters, which eventually play a role in progression development mental illness. The nitrogen-containing heterocyclic compounds exhibit most prominent pharmacological profile as antidepressants. Pyrazoline, dihydro derivative pyrazole, well-known five-membered moiety exhibits broad spectrum biological activities. Many researchers have reported pyrazoline scaffold-containing molecules potential antidepressant agents selectivity for monoamine oxidase enzyme (MAO) isoforms. Several studies indicated better affinity pyrazoline-based (monoamine inhibitors) MAOIs. In this review, we focused on recent advancements (2019-2023) pyrazoline-containing derivatives exhibiting promising inhibition MAO-A treat depression. This review provides structural insights along their SAR analysis, silico exploration binding interactions between enzyme, clinical trial status various drug against in-silico potent at active site MAOA will provide further into new inhibitors treatment
Language: Английский
Citations
4
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Astrocytes exert multiple functions within the brain, including regulating neuroinflammation and maintaining homeostasis, reactive astrocytes are implicated in many neurodegenerative disorders. Imidazoline-2 binding site (I2BS) has been established as a reliable biomarker for precisely quantifying astrocytes. Here, we reported development of [125I]iodotrazoline ([125I]8), novel I2BS radioligand with high affinity (Ki = 6.8 nM) exceptional selectivity over α2-adrenoceptors (>1400 folds). In vitro autoradiography (ARG) using rat brain sections revealed heterogeneous distribution [125I]8, signals medulla, midbrain, pons, hypothalamus. Pretreatment unlabeled I2BS-selective ligands, BU224 FTIMD, reduced by >30%, indicating specificity I2BS. Ex vivo ARG results confirmed this pattern brain. Biodistribution mice demonstrated rapid uptake [125I]8 (3.35% ID/g at 2 min postinjection) slow washout. Metabolite analysis exhibited desirable biostability Altogether, work provides new 125I-labeled featuring 2-trans-styryl-imidazoline scaffold, which shows significant vitro, serving valuable tool detection astrocyte-related pathology research.
Language: Английский
Citations
0
Journal of Pain Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 2223 - 2248
Published: Aug. 1, 2022
Abstract: Chronic pain remains a public health problem and contributes to the ongoing opioid epidemic. Current management therapies still leave many patients with poorly controlled pain, thus new or improved treatments are desperately needed. One major challenge in research is translation of preclinical findings into effective clinical practice. The local neuroimmune interface plays an important role initiation maintenance chronic therefore promising target for novel therapeutic development. Neurons immune immunocompetent cells distinct microenvironments along nociceptive circuitry. can modulate activity property neurons affect peripheral central sensitization. In this review, we highlight specific subset interfaces. nervous system, examine between microglia, astrocytes, T lymphocytes. periphery, profile dorsal root ganglion lymphocytes, satellite glial cells, macrophages. To bridge gap practice, review studies each interface, discuss current medicine that may exert its action at opportunities future efforts. Keywords: neuroimmune, macrophage, T-cells
Language: Английский
Citations
18
Biomedicines, Journal Year: 2022, Volume and Issue: 10(2), P. 305 - 305
Published: Jan. 28, 2022
Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis our understanding of Alzheimer’s Disease (AD). Despite knowledge gained from human studies, mouse models continue to play an important role deciphering cellular molecular evolution AD. MRI PET are now being increasingly used investigate neuroimaging features provide basis for rapid translation clinical setting. Here, we overview landscape as a prelude in-depth review preclinical mice. A broad range recapitulate certain aspects AD, but no single model simulates disease spectrum. We focused on two most popular models, 3xTg-AD 5xFAD summarized all known published data, including contrasting findings. The goal this is reader with framework guide future studies existing also highlight that could be improved increase rigor reproducibility studies.
Language: Английский
Citations
17