Biomedical Application Prospects of Gadolinium Oxide Nanoparticles for Regenerative Medicine DOI Creative Commons
Ekaterina Silina, Н.Е. Мантурова,

Elena L. Chuvilina

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1627 - 1627

Published: Dec. 23, 2024

Background/Objectives: The aim was to study the possibilities of biomedical application gadolinium oxide nanoparticles (Gd2O3 NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological safety using different human cell lines. Methods: powder Gd2O3 NPs obtained by a process thermal decomposition carbonate precipitated from nitrate solution, studied transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, mass spectrometry, scanning (SEM) with energy dispersive analyzer (EDX). activity concentrations optical spectroscopy (OS) method in photochemical degradation methylene blue dye upon irradiation an source. Biological on lines (keratinocytes, fibroblasts, mesenchymal stem cells (MSCs)) evaluation effect wide range NP metabolic proliferative cellular (MTT test, direct counting, dead assessment, visual assessment cytoarchitectonics). test migration model wound performed MSC culture. Results: According TEM data, size 2–43 nm, average 20 nm. XRD analysis revealed that f had cubic structure (C-form) (Ia3)¯ lattice parameter = 10.79(9) Å. showed high degree crystallinity. By investigating photooxidative presence red light irradiation, it found weak antioxidant which depended particle content solution. At concentration 10−3 M, highest observed when reaction rate constant photodegradation decreased 5.5% 9.4 × min−1. When solution increased 10−2 M source, changed pro-oxidant accompanied 15% increase degradation. Studies level regenerative potential NPs, stimulated fibroblast metabolism at (27% enhancement), keratinocyte M–10−5 enhanced proliferation 35% 10−4 M. Furthermore, accelerated MSCs, enhancing proliferation, promoting healing wound. Conclusions: results demonstrated redox-active towards This may be basis for further research develop nanomaterials based skin medicine generally.

Language: Английский

Advances in Nanotechnology for the Diagnosis and Management of Metabolic Dysfunction-associated Steatotic Liver Disease DOI Creative Commons
Fenfen Li,

Ruyan Yuan,

Jiamin Zhang

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101025 - 101025

Published: Feb. 1, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) has a high global incidence and associated with increased lipid accumulation in hepatocytes, elevated hepatic enzyme levels, fibrosis, carcinoma. Despite decades of research significant advancements, the treatment MASLD still faces formidable challenges. Nanoprobes for diagnostics nanomedicine targeted drug delivery to present promising options diagnosis treatment, enhancing both imaging contrast bioavailability. Here, we review recent advances nanotechnology applied specifically focusing on systems targeting stellate cells, Kupffer sinusoidal endothelial cells. This aims provide an overview nanomedicine's potential early therapeutic interventions, addressing related complications.

Language: Английский

Citations

0
Changes in the relaxivity of water‐organic solvent miscible systems: Hidden forces beyond metal ions DOI Open Access
Shiman Wu,

Chaochao Wang,

Junjie Xia

et al.

Medical Physics, Journal Year: 2024, Volume and Issue: 52(2), P. 1108 - 1118

Published: Oct. 29, 2024

The relaxivity of magnetic resonance imaging (MRI) contrast agents is primarily attributed to metal ions such as gadolinium (Gd) and iron. However, the impact organic solutes on relaxivity, particularly through alterations in water molecule dynamics, has not been thoroughly investigated. This research was aimed explore how affect relaxivities Gd-based (GBCAs), potentially revealing new aspects for development agents. To investigate effects different proportions water-soluble solvents mixed with pure GBCA T1 T2 relaxivities. Ethanol, dimethyl sulfoxide (DMSO), 1,4-dioxane, glycerin, ethylene glycol, diethylene polyethylene glycol (PEG) 200, PEG 400 were ultrapure various ratios (100:0, 90:10, 80:20, 70:30, 60:40, 50:50, 40:60, 30:70, 20:80, 10:90, 0:100). added these mixtures at a concentration 0.05 mmol/L. underwent mapping scans using 3.0 Tesla MRI machine, R1 (1/T1) R2 (1/T2) calculated compared. ethanol, DMSO or GBCA, well initially increased then decreased. Conversely, significantly higher glycerin GBCA. increase correlated greater viscosity. When proportion exceeded 20%, minimal variability observed content Adding paramagnetic relaxation reagents could alter relaxivities, suggesting potential directions modifying current Additionally, increasing viscosity agent found enhance relaxivity.

Language: Английский

Citations

0
Biomedical Application Prospects of Gadolinium Oxide Nanoparticles for Regenerative Medicine DOI Creative Commons
Ekaterina Silina, Н.Е. Мантурова,

Elena L. Chuvilina

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1627 - 1627

Published: Dec. 23, 2024

Background/Objectives: The aim was to study the possibilities of biomedical application gadolinium oxide nanoparticles (Gd2O3 NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological safety using different human cell lines. Methods: powder Gd2O3 NPs obtained by a process thermal decomposition carbonate precipitated from nitrate solution, studied transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, mass spectrometry, scanning (SEM) with energy dispersive analyzer (EDX). activity concentrations optical spectroscopy (OS) method in photochemical degradation methylene blue dye upon irradiation an source. Biological on lines (keratinocytes, fibroblasts, mesenchymal stem cells (MSCs)) evaluation effect wide range NP metabolic proliferative cellular (MTT test, direct counting, dead assessment, visual assessment cytoarchitectonics). test migration model wound performed MSC culture. Results: According TEM data, size 2–43 nm, average 20 nm. XRD analysis revealed that f had cubic structure (C-form) (Ia3)¯ lattice parameter = 10.79(9) Å. showed high degree crystallinity. By investigating photooxidative presence red light irradiation, it found weak antioxidant which depended particle content solution. At concentration 10−3 M, highest observed when reaction rate constant photodegradation decreased 5.5% 9.4 × min−1. When solution increased 10−2 M source, changed pro-oxidant accompanied 15% increase degradation. Studies level regenerative potential NPs, stimulated fibroblast metabolism at (27% enhancement), keratinocyte M–10−5 enhanced proliferation 35% 10−4 M. Furthermore, accelerated MSCs, enhancing proliferation, promoting healing wound. Conclusions: results demonstrated redox-active towards This may be basis for further research develop nanomaterials based skin medicine generally.

Language: Английский

Citations

0