Approaches to Radiolabeling Nanobodies for Biomedical Applications

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Molecular imaging plays a vital role in diagnosing diseases, monitoring treatments, and evaluating therapeutic efficacy by enabling noninvasive visualization of biological processes. Nanobodies, single-domain antibodies derived from camelids, have emerged as promising candidates for wide range biomedical applications due to their unique properties, including small size, high affinity, rapid clearance, deep-tissue penetration. While effective radiolabeling techniques remain major challenge fully realize clinical potential, this review aims present recent advances nanobody radiolabeling, focusing on radionuclides like 64Cu, 68Ga, 89Zr, 111In, along with associated chelators conjugation methods. We highlight the development innovative chelators, p-SCN-Bn-HOPO desferrioxamine derivatives that enhance specificity stability, well influence biodistribution pharmacokinetics. These findings essential nanobody-based molecular precise diagnostics targeted therapy.

Language: Английский

CD70-targeted cancer theranostics: Progress and challenges

Med, Journal Year: 2025, Volume and Issue: unknown, P. 100671 - 100671

Published: April 1, 2025

Language: Английский