Metabolic-Dysfunction-Associated Steatotic Liver Disease: Molecular Mechanisms, Clinical Implications, and Emerging Therapeutic Strategies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2959 - 2959

Published: March 25, 2025

Metabolic-dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is a highly prevalent metabolic disorder characterized by hepatic steatosis in conjunction with at least one cardiometabolic risk factor, such obesity, type 2 diabetes, hypertension, or dyslipidemia. As global rates of obesity and syndrome continue to rise, MASLD becoming major public health concern, projections indicating substantial increase prevalence over the coming decades. The spectrum ranges from simple metabolic-dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, hepatocellular carcinoma, contributing significant morbidity mortality worldwide. This review delves into molecular mechanisms driving pathogenesis, including dysregulation lipid metabolism, chronic inflammation, oxidative stress, mitochondrial dysfunction, gut microbiota alterations. Recent advances research have highlighted role genetic epigenetic factors progression, well novel therapeutic targets peroxisome proliferator-activated receptors (PPARs), fibroblast growth factors, thyroid hormone receptor beta agonists. Given multifaceted nature MASLD, multidisciplinary approach integrating early diagnosis, insights, lifestyle interventions, personalized therapies critical. underscores urgent need for continued innovative treatment strategies precision medicine approaches halt progression improve patient outcomes.

Language: Английский

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The potential for primary and secondary prevention of liver cancer death in Australians with alcohol-related liver disease or metabolic-associated steatotic liver disease: A modelling study

Public Health, Journal Year: 2025, Volume and Issue: 243, P. 105718 - 105718

Published: April 14, 2025

Language: Английский

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Unmet needs of metabolic dysfunction – Associated “fatty or steatotic” liver disease

Tzu Chi Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Nonalcoholic fatty liver disease (NAFLD), first named in 1980, is currently the most common chronic disease, imposing significant health, social, and economic burdens. However, it defined as a diagnosis of exclusion, lacking clear underlying cause its diagnostic criteria. In 2020, metabolic dysfunction-associated (MAFLD) was proposed replacement for NAFLD, introducing additional criteria related to dysfunction. 2023, steatotic (MASLD) suggested replace aiming avoid stigmatizing term "fatty" incorporating cardiometabolic This divergence nomenclature between MAFLD MASLD presents challenges medical communication progress. review outlines pros cons both terminologies, based on current research evidence, hope fostering global consensus future.

Language: Английский

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Comparison of Vendor-Independent Software Tools for Liver Proton Density Fat Fraction Estimation at 1.5 T

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1138 - 1138

Published: May 30, 2024

(1) Background: Open-source software tools are available to estimate proton density fat fraction (PDFF). (2) Methods: We compared four algorithms: complex-based with graph cut (GC), magnitude-based (MAG), magnitude-only estimation Rician noise modeling (MAG-R), and multi-scale quadratic pseudo-Boolean optimization (QPBO). The accuracy reliability of the methods were evaluated in phantoms known fat/water ratios a patient cohort various grades (S0-S3) steatosis. Image acquisitions performed at 1.5 Tesla (T). (3) Results: PDFF estimates showed nearly perfect correlation (Pearson r = 0.999,

Language: Английский

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Prevalence, characteristics and outcomes of patients with metabolic and alcohol related/associated liver disease: a systematic review and meta-analysis

Metabolism, Journal Year: 2024, Volume and Issue: 163, P. 156101 - 156101

Published: Dec. 10, 2024

Language: Английский

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