Performance of Magnetic Resonance Imaging and Ultrasound for Identifying the Different Degrees of Hepatic Steatosis: A Systematic Review and Meta-analysis DOI Creative Commons

Shuzhen Wu,

Junhan Pan,

Mengchen Song

et al.

Academic Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

MRI proton density fat fraction (MRI-PDFF), controlled attenuation parameters (CAP), and coefficients (AC) are capable of steatosis characterization may be useful as noninvasive alternatives for diagnosing hepatic steatosis. This meta-analysis aimed to evaluate the performance MRI-PDFF, CAP, AC in grading steatosis, using histology reference standard. We conducted a comprehensive search PubMed, Cochrane Library, Embase, Web Science databases until June 2024. The quality eligible studies was assessed. Pooled sensitivity, specificity, area under receiver operating characteristic (AUC) curves were calculated bivariate random-effects model. Meta-regression analysis, subgroup Deeks' test performed explore heterogeneity assess publication bias. included 38 with 5056 patients metabolic dysfunction-associated steatotic liver disease. AUC values ≥S1, ≥S2, ≥S3 0.99, 0.89, 0.90 0.95, 0.84, 0.77 0.97, 0.90, 0.89 AC, respectively. CAP demonstrated lower accuracy detecting grades ≥S2 compared MRI-PDFF (0.89 vs. p<0.001; 0.77, p<0.001) (0.90 p<0.001). Subgroup analyses revealed that exhibited superior diagnostic among individuals Asia, body mass index ≤30 kg/m2, age <51 years. A direct comparison showed greater moderate severe similar AC. For should incorporated into routine ultrasound screening.

Language: Английский

Fetuin-A: a relevant novel serum biomarker for non-invasive diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD): a retrospective case-control study DOI Creative Commons
Mohamed Mahmoud Elhoseeny,

Badawy A. Abdulaziz,

Mohamed A. Mohamed

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 18, 2024

Abstract Objectives To determine how fetuin-A contributes to diagnosing and assessing MASLD severity. Methods Fifty patients fifty healthy control participants were involved in this retrospective case-control research. Abdominal ultrasonography, fibroscan with controlled attenuated parameter scan (CAP scan), laboratory investigation (including assessment), clinical examination, history-taking performed on every case. Results Fetuin-A level was considerably higher the Cases group (1154.85 ± 629.89) than Control (505.29 150.4) ( p < 0.001). had significant validity prediction of at a cut-off > 702.5 82% sensitivity, 90% specificity, 86% overall accuracy. Conclusion One possible marker for diagnosis could be fetuin-A. Furthermore, substantial association between such severity disease as it revealed correlation ultrasound grading parameters. Trial registration 1- Pan African Clinical Registry. Unique Identifying number/registration ID: PACTR202309644280965. URL: https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=26860 . Registration Approval date: 21/09/2023. 2- ClinicalTrials.gov number /registration NCT06097039. https://clinicaltrials.gov/study/NCT06097039?cond=NCT06097039&rank=1 25/10/2023.

Language: Английский

Citations

6
Curcumin inhibits pancreatic steatosis in mice with high fat diet through YAP/P53 pathway and confirmed through ultrasonic imaging DOI

Helin Ke,

Ziwei Xu,

Lina Han

et al.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2025, Volume and Issue: unknown, P. 159605 - 159605

Published: Feb. 1, 2025

Language: Английский

Citations

0
Performance of Magnetic Resonance Imaging and Ultrasound for Identifying the Different Degrees of Hepatic Steatosis: A Systematic Review and Meta-analysis DOI Creative Commons

Shuzhen Wu,

Junhan Pan,

Mengchen Song

et al.

Academic Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

MRI proton density fat fraction (MRI-PDFF), controlled attenuation parameters (CAP), and coefficients (AC) are capable of steatosis characterization may be useful as noninvasive alternatives for diagnosing hepatic steatosis. This meta-analysis aimed to evaluate the performance MRI-PDFF, CAP, AC in grading steatosis, using histology reference standard. We conducted a comprehensive search PubMed, Cochrane Library, Embase, Web Science databases until June 2024. The quality eligible studies was assessed. Pooled sensitivity, specificity, area under receiver operating characteristic (AUC) curves were calculated bivariate random-effects model. Meta-regression analysis, subgroup Deeks' test performed explore heterogeneity assess publication bias. included 38 with 5056 patients metabolic dysfunction-associated steatotic liver disease. AUC values ≥S1, ≥S2, ≥S3 0.99, 0.89, 0.90 0.95, 0.84, 0.77 0.97, 0.90, 0.89 AC, respectively. CAP demonstrated lower accuracy detecting grades ≥S2 compared MRI-PDFF (0.89 vs. p<0.001; 0.77, p<0.001) (0.90 p<0.001). Subgroup analyses revealed that exhibited superior diagnostic among individuals Asia, body mass index ≤30 kg/m2, age <51 years. A direct comparison showed greater moderate severe similar AC. For should incorporated into routine ultrasound screening.

Language: Английский

Citations

0