The Rational Engineered Bacteria Based Biohybrid Living System for Tumor Therapy DOI Open Access
Chen Wang,

Qiliner Feng,

Si Shi

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 25, 2024

Abstract Living therapy based on bacterial cells has gained increasing attention for their applications in tumor treatments. Bacterial can naturally target to sites and active the innate immunological responses. The intrinsic advantages of bacteria attribute development biohybrid living carriers targeting delivery toward hypoxic environments. rationally engineered integrate various functions enhance reduce toxic side effects. In this review, antitumor effects application are discussed as therapeutic agents across multiple platforms. kinds used cancer first introduced demonstrated mechanism well Additionally, study focused genetically modified production system treat cancer. combination with functional nanomaterials is then brief, rational design highlighted a rapid pointed out potentials clinical applications.

Language: Английский

Linoleic Acid, Mitochondria, Gut Microbiome, and Metabolic Health: A Mechanistic Review DOI Creative Commons

Joseph Mercola

Advances in Redox Research, Journal Year: 2025, Volume and Issue: unknown, P. 100128 - 100128

Published: April 1, 2025

Language: Английский

Citations

0
The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy DOI

Y. Situ,

Pengpeng Zhang, Cangang Zhang

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105708 - 105708

Published: April 22, 2025

Language: Английский

Citations

0
Integrating molecular pathway with genome-wide association data for causality identification in breast cancer DOI Creative Commons
Yan-Shuang Li, Hongchuan Jiang

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 2, 2024

Abstract Objective The study purpose was to explore the causal association between pyruvate metabolism and breast cancer (BC), as well molecular role of key metabolic genes, by using bioinformatics Mendelian randomization (MR) analysis. Methods We retrieved examined diverse datasets from GEO database ascertain differentially acting genes (DAGs) in BC via differential expression Following this, we performed functional pathway enrichment analyses noteworthy functions pathways BC. Employing MR analysis, established a susceptibility Additionally, utilizing DGIdb database, identified potential targeted medications that act on implicated formulated competing endogenous RNA (ceRNA) regulatory network Results collected GSE54002, GSE70947, GSE22820, total 1127 DEGs NC groups. GO KEGG analysis showed these mainly included mitotic nuclear division, extracellular matrix, signaling receptor activator activity, etc. Metabolic were concentrated PI3K−Akt pathway, Cytokine−cytokine binding Pyruvate, Tyrosine, Propanoate Phenylalanine metabolism, In addition, demonstrated relationship risk. Finally, constructed (ADH1B, ACSS2, ACACB, ADH1A, ALDH2, ADH1C) drugs, ceRNA (lncRNA-miRNA-mRNA) for BC, further revealing their interactions. Conclusions Our research revealed risk, found ADH1B, ADH1C takes place an important part development mechanisms related some small molecule drugs.

Language: Английский

Citations

0
The Rational Engineered Bacteria Based Biohybrid Living System for Tumor Therapy DOI Open Access
Chen Wang,

Qiliner Feng,

Si Shi

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 25, 2024

Abstract Living therapy based on bacterial cells has gained increasing attention for their applications in tumor treatments. Bacterial can naturally target to sites and active the innate immunological responses. The intrinsic advantages of bacteria attribute development biohybrid living carriers targeting delivery toward hypoxic environments. rationally engineered integrate various functions enhance reduce toxic side effects. In this review, antitumor effects application are discussed as therapeutic agents across multiple platforms. kinds used cancer first introduced demonstrated mechanism well Additionally, study focused genetically modified production system treat cancer. combination with functional nanomaterials is then brief, rational design highlighted a rapid pointed out potentials clinical applications.

Language: Английский

Citations

0