Ascites and Serum Interleukin-10 Levels as a Prognostic Tool for Ovarian Cancer Outcomes DOI Open Access
Paul‐Adrien Guigue, Yoav Brezinov, Amber Yasmeen

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2840 - 2840

Published: Aug. 14, 2024

Interleukin-10 (IL-10) has been shown to be present at high levels in the ascites of ovarian cancer (OC) patients; however, little is known about its prognostic value. We sought correlate IL-10 and sera OC patients with clinicopathologic characteristics oncologic outcomes. clinical data from biobanked serum samples were evaluated. Receiver operating characteristic curves used quantify marker performance identify IL-10-high IL-10-low groups. Correlations between performed. Survival outcomes calculated, while factors affecting them also investigated. A total 106 had samples, which 44 available. Mean significantly higher serous histology compared endometrioid (p = 0.024). Fold-change during treatment positively correlated response, as determined by a change antigen (CA)-125 0.0126). Median progression-free survival (PFS) overall (OS) shorter low (PFS: 18 versus 60 months; p 0.007, OS: 42 85 0.029). significant positive correlation was seen 0.019). In multivariable analyses, level associated worse prognosis (PFS hazard ratio (HR) 1.93; 0.02). Patients have outcomes, are likely reflective immunosuppressive effect IL-10. This highlights potential role an immunomodulator tumor microenvironment, leading immune evasion.

Language: Английский

Targeting T cell exhaustion: emerging strategies in non-small cell lung cancer DOI Creative Commons
Xianqiang Liu, Xiaowei Xi, Shengshan Xu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Lung cancer continues to be a major contributor cancer-related deaths globally. Recent advances in immunotherapy have introduced promising treatments targeting T cell functionality. Central the efficacy of these therapies is role cells, which are often rendered dysfunctional due continuous antigenic stimulation tumor microenvironment–a condition referred as exhaustion. This review addresses critical challenge exhaustion non-small lung (NSCLC), offering detailed examination its molecular underpinnings and resultant therapeutic ineffectiveness. We synthesize current knowledge on drivers exhaustion, evaluate emerging strategies for reversal, explore potential impact insights enhancing clinical immunotherapies. By consolidating reported trials preclinical studies, this article highlights innovative approaches modulate immune responses improve patient outcomes, thus providing roadmap future research development immunotherapy.

Language: Английский

Citations

6
Platinum(IV) Complexes Trigger Death Receptors and Natural Killer Cells to Suppress Breast Cancer DOI
Linxiang Cai, Hanhua Chen, Ying Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Chemoimmunotherapy is an alternative treatment against cancers. Platinum(IV) complexes FMP and DFMP, coupling formononetin derivative as axial ligand(s), were designed to suppress triple-negative breast cancer (TNBC) by activating death receptors (DRs) natural killer (NK) cells. These show great potential overcome the resistance of TNBC chemotherapy inducing both intrinsic extrinsic apoptosis in Particularly, with one not only induced caspase-3-dependent but also upregulated expression DRs caspase-8, triggered apoptosis, enhanced cytotoxic ability NK92 Moreover, increased release granzyme B, restrained proliferation differentiation myeloid-derived suppressor cells, secretion IL-10, thus inhibiting vitro vivo. The results demonstrate that overcomes chemoresistance immune escape through a new mechanism involving synergy immunotherapy.

Language: Английский

Citations

0
Preparation, physicochemical characterization and functional properties of selenium nanoparticles stabilized by polysaccharides from the seeds of Plantago asiatica L DOI Open Access
Huimei Wang, Chang Li, Yingzhi Li

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Selenium nanoparticles (SeNPs), comprising a novel selenium element with higher bioactivity, easily aggregate into large black monomeric particles. In the present study, polysaccharides from seeds of Plantago asiatica L. (PLP) was used as template and morphology/particle size modifier to synthesize nanoparticles. The preparation process SeNPs stabilized by PLP optimized, its antioxidant immunological activities were investigated. optimal conditions PLP-SeNPs reaction temperature 60°C, time 1.5 h, concentration 0.04 mg · mL-1 Na2SeO3/Vc molar ratio 1:5. Stable spherical particle 78.39 ± 2.15 nm prepared through this process. complex at 32 μg demonstrated scavenging against 1,1-diphenyl-2-picrylhydrazyl radicals, hydroxyl radicals 2,2'-azinobis-(3-ethyl-benzothiazolin-6-sulfonic acid) diammonium salt up 49.49 2.58%, 60.99 2.49% 42.07 1.76%, respectively. significantly increased activation RAW264.7 cells improving phagocytosis, reactive oxygen species levels, secretion tumor necrosis factor-α interleukin-10. study lays theoretical foundation for development food-borne exploration their application in functional foods, which will help promote high-value utilization P. L., also has an important guiding significance healthy selenium-enriched food industry. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
CD44-Targeted nanoparticles for remodeling the tumor microenvironment in a 3D Macrophage-Embedded ovarian cancer model with stem Cell-Like features DOI

Samjhana Shrestha,

Anil K Giri,

Prabhat Shrestha

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125483 - 125483

Published: March 1, 2025

Language: Английский

Citations

0
Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy DOI Creative Commons

Ludovica Lopresti,

Vanessa Tatangelo, Cosima T. Baldari

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as effective anti-cancer agents. Within TME, cell-to-cell inhibitory interactions play significant roles in dampening their anti-tumor activities. Recent studies have revealed soluble factors released TME by immune and non-immune cells, well cells themselves, contribute exacerbation of cell exhaustion. Our understanding cytokine landscape interrelationships, impact on cancer development is still at its early stages. In this review, we aim shed light Interleukin (IL) -6, IL-9, IL-10, a small group JAK/STAT signaling-dependent cytokines harboring cell-suppressive effects summarize mechanisms action. Additionally, will explore how advancements scientific research can help us overcoming obstacles posed suppress tumors, with ultimate objective stimulating further investigations for novel therapeutic strategies counteract tumor-promoting

Language: Английский

Citations

2
Intraperitoneal administration of doxorubicin-encapsulated Brucea javanica oil nanoemulsion against malignant ascites DOI
Jie Dai, Renjin Chen, Jie Wang

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 202, P. 114422 - 114422

Published: July 20, 2024

Language: Английский

Citations

1
Ascites and Serum Interleukin-10 Levels as a Prognostic Tool for Ovarian Cancer Outcomes DOI Open Access
Paul‐Adrien Guigue, Yoav Brezinov, Amber Yasmeen

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2840 - 2840

Published: Aug. 14, 2024

Interleukin-10 (IL-10) has been shown to be present at high levels in the ascites of ovarian cancer (OC) patients; however, little is known about its prognostic value. We sought correlate IL-10 and sera OC patients with clinicopathologic characteristics oncologic outcomes. clinical data from biobanked serum samples were evaluated. Receiver operating characteristic curves used quantify marker performance identify IL-10-high IL-10-low groups. Correlations between performed. Survival outcomes calculated, while factors affecting them also investigated. A total 106 had samples, which 44 available. Mean significantly higher serous histology compared endometrioid (p = 0.024). Fold-change during treatment positively correlated response, as determined by a change antigen (CA)-125 0.0126). Median progression-free survival (PFS) overall (OS) shorter low (PFS: 18 versus 60 months; p 0.007, OS: 42 85 0.029). significant positive correlation was seen 0.019). In multivariable analyses, level associated worse prognosis (PFS hazard ratio (HR) 1.93; 0.02). Patients have outcomes, are likely reflective immunosuppressive effect IL-10. This highlights potential role an immunomodulator tumor microenvironment, leading immune evasion.

Language: Английский

Citations

1