Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(4), P. 267 - 267
Published: April 9, 2025
Histone
demethylases
(HDMs)
play
a
pivotal
role
in
colorectal
cancer
(CRC)
progression
through
dynamic
epigenetic
regulation.
This
review
summarizes
the
and
therapeutic
potential
of
HDM
CRC.
HDMs
primarily
target
lysine
(K)
for
demethylation
(lysine
demethylase,
KDM).
The
KDM
family
is
divided
into
lysine-specific
demethylase
Jumonji
C
domain-containing
family.
complex
roles
CRC
cell
proliferation,
invasion,
migration,
stemness,
epithelial–mesenchymal
transition,
immune
response,
chemoresistance
regulation
different
histone
sites.
Increasing
evidence
suggests
that
may
interact
with
certain
factors
regulate
tumorigenesis
by
modulating
multiple
signaling
pathways
affecting
transcription
genes.
These
processes
be
regulated
upstream
genes
thus
form
regulatory
network.
However,
mechanisms
some
remain
understudied.
Preclinical
studies
have
revealed
small-molecule
inhibitors
targeting
impact
activity
specific
inhibiting
expression,
thereby
reshaping
tumorigenic
landscape
clinical
translational
these
remains
unexplored.
In
conclusion,
critical
dynamically
regulating
methylation
patterns.
shape
malignant
behavior
influencing
key
reprogramming.
Targeting
promising
direction
treatment.
Further
exploration
HDM-specific
needed
future.
Language: Английский
Mapping small metabolite changes after traumatic brain injury using AP-MALDI MSI
Angela Marika Siciliano,
No information about this author
Federico Moro,
No information about this author
Giulia De Simone
No information about this author
et al.
Analytical and Bioanalytical Chemistry,
Journal Year:
2024,
Volume and Issue:
416(22), P. 4941 - 4949
Published: Aug. 1, 2024
Abstract
Traumatic
brain
injury
(TBI)
is
an
alteration
of
function
caused
by
a
sudden
transmission
external
force
to
the
head.
The
biomechanical
impact
induces
acute
and
chronic
metabolic
changes
that
highly
contribute
evolution
outcome.
TBI
heterogeneity
calls
for
approaches
allowing
mapping
regional
molecular
underpinning
disease
progression,
with
mass
spectrometry
imaging
(MSI)
as
efficient
tool
study
spatial
distribution
small
metabolites.
In
this
study,
we
applied
innovative
targeted
atmospheric
pressure-MALDI
(AP-MALDI
MSI)
approach,
starting
from
extensive
list
metabolites,
representative
different
pathways,
individually
validated
on
tissue
under
analysis
original
standards
using
2,5-dihydroxybenzoic
acid
(DHB),
characterize
metabolites
in
brain.
Brains
sham
mice
obtained
21
days
post-injury
were
analyzed
examine
profile
belonging
pathways.
By
whole
analysis,
identified
four
(alanine,
lysine,
histidine,
inosine)
higher
abundance
than
mice.
Within
group,
inosine
hemisphere
ipsilateral
vs.
contralateral
one.
Images
showed
major
involvement
thalamus
characterized
increase
arginine,
significant
reduction
glutamic
acid,
N-acetylaspartic
compared
thalamus.
These
findings
indicate
high-resolution
powerful
identify
region-specific
after
understand
underlying
evolution.
Language: Английский
Research progress of tumor-associated macrophages in immune checkpoint inhibitor tolerance in colorectal cancer
Fan Qi,
No information about this author
Zhengwei Fu,
No information about this author
Ming Xu
No information about this author
et al.
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(10), P. 4064 - 4079
Published: Sept. 25, 2024
The
relevant
mechanism
of
tumor-associated
macrophages
(TAMs)
in
the
treatment
colorectal
cancer
patients
with
immune
checkpoint
inhibitors
(ICIs)
is
discussed,
and
application
prospects
TAMs
reversing
tolerance
ICIs
are
discussed
to
provide
a
reference
for
related
studies.
As
class
drugs
widely
used
clinical
tumor
immunotherapy,
can
act
on
regulatory
molecules
cells
that
play
an
inhibitory
role-immune
checkpoints-and
kill
tumors
form
response
by
activating
variety
system.
sensitivity
different
types
ICI
varies
greatly.
phenotype
function
microenvironment
closely
efficacy
ICIs.
regulate
phenotypic
TAMs,
also
affect
therapy.
important
role
resistance,
making
full
use
this
target
as
therapeutic
strategy
expected
improve
immunotherapy
prognosis
cancer.
Language: Английский
Intermittent Fasting Enhances the Antitumor Activity of Cisplatin and Metformin Combination in Therapy-Resistant Ovarian Cancer PDXs
Published: Jan. 1, 2024
The
development
of
platinum
resistance
is
a
significant
challenge
in
the
management
ovarian
cancer.
Targeting
metabolic
adaptability
cancer
cells
and
combining
dietary
interventions
with
pharmacological
treatments
are
emerging
strategies
oncology,
enhancing
therapy
efficacy
at
low
costs.
Using
cisplatin
resistant
patient-derived
xenografts,
we
showed
that
repeated
cycles
plus
metformin
reversed
by
remodelling
tumour
metabolism.
Then,
based
on
metabolomic
studies,
explored
use
different
food
approaches,
particular
diets
high
vs
methionine
content,
intermittent
fasting
regimen,
to
further
stress
metabolism,
increase
effect
drug
treatment.
Our
findings
demonstrated
only
enhanced
antitumor
effects
combination,
significantly
improved
survival,
impairing
energy
states.
This
research
highlights
potential
integrating
food-based
approaches
overcome
Language: Английский