Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(8), P. 407 - 431

Published: July 3, 2023

Language: Английский

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Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 21, 2023

Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit variety of gastrointestinal even take symptoms as the primary reason medical treatment. It well documented that stress disrupt balance gut microbiome in suffering from post-stroke (PSD), disruption closely related to severity condition patients. Therefore, maintaining intestinal microbiota can be focus research on mechanism acupuncture treatment PSD. Furthermore, stroke effectively treated with at all stages it act special microecological regulator by regulating well. In this article, we reviewed studies changing after examined existing problems development prospects acupuncture, microbiome, poststroke depression, order provide new ideas future research.

Language: Английский

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Neuroinflammation and Brain Disease

BMC Neurology, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 12, 2023

Abstract Starting from the perspective of an immune-privileged site, our knowledge inflammatory processes within central nervous system has increased rapidly over last 30 years, leading to a rather puzzling picture today. Of particular interest is emergence disease- and injury-specific responses brain, which may form basis for future therapeutic approaches. To advance this important topic, we invite authors contribute research clinical papers Collection “Neuroinflammation Brain Disease”.

Language: Английский

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Acute liver damage generates age independent microglia morphology changes in mice

Romanian Journal of Morphology and Embryology, Journal Year: 2025, Volume and Issue: 65(4), P. 679 - 685

Published: Feb. 13, 2025

Non-alcoholic fatty liver disease (NAFLD) has emerged as a silent global epidemic, frequently contributing to systemic inflammation. As the primary immune cells of central nervous system (CNS), microglia undergo morphological changes that serve critical indicators CNS health. In this study, we aimed quantify alterations in microglial morphology within cortex young and aged mice with damage. Our results demonstrated hepatic dysfunction leads significant increase total branch length both (285.79±68.23 μm) animals (268.67±69.06 μm), compared their respective controls (164.07±33.05 μm 140.96±27.18 (p 0.0001). Additionally, damage exhibited mean 5.84±0.66 μm, higher than 2.63±0.19 observed those without injury. The number branches decreased from 6.6±1.2 3.1±1.5 addition, have shown decrease secondary This suggests not only respond CNS-specific injuries but also chronic pathologies like NAFLD. These findings highlight importance better understanding liver–brain axis order understand neuroimmune consequences diseases.

Language: Английский

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Molecular heterogeneity in human stroke – What can we learn from the peripheral blood transcriptome?

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Stroke is a multifaceted disease with genetic and environmental components like diet lifestyle. The central nervous immune systems display complex interactions, the peripheral response participating in brain injury repair mechanisms following stroke. bidirectional communication between injured blood presents an opportunity to investigate molecular changes latter. There substantial heterogeneity stroke pathogenesis, pathophysiology, comorbidities, treatment outcome. This captured underscored by transcriptome. current review highlights role of human transcriptome architecture for phenotyping different etiologies identifying underlying correlates clinically important variables outcomes. Specific features can potentially provide targets clinical translation prioritizing genes pathways evaluation experimental models. We also propose approach study patient-specific transcriptional uncover combinatorial altered patients that guide search prevention targets. Deciphering tissue be easily accessed monitored, such as blood, may improve trial success.

Language: Английский

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Advancing Post-Stroke Depression Research: Insights from Murine Models and Behavioral Analyses

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1110 - 1110

Published: Sept. 3, 2024

Post-stroke depression (PSD) represents a significant neuropsychiatric complication that affects between 39% and 52% of stroke survivors, leading to impaired recovery, decreased quality life, increased mortality. This comprehensive review synthesizes our current knowledge PSD, encompassing its epidemiology, risk factors, underlying neurochemical mechanisms, the existing tools for preclinical investigation, including animal models behavioral analyses. Despite high prevalence severe impact challenges persist in accurately modeling complex symptomatology settings, underscoring need robust valid better understand treat PSD. also highlights multidimensional nature where both biological psychosocial factors interplay influence onset course. Further, we examine efficacy limitations mimicking human PSD condition, along with tests used evaluate depressive-like behaviors rodents. sets new precedent by integrating latest findings across multidisciplinary studies, thereby offering unique perspective knowledge. Finally, development more sophisticated closely replicate clinical features is crucial order advance translational research facilitate discovery future effective therapies.

Language: Английский

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Salidroside attenuates cognitive deficits induced by chronic cerebral hypoperfusion via modulating microglial phenotypic transformation in mice

Journal of Neuroimmunology, Journal Year: 2025, Volume and Issue: 400, P. 578544 - 578544

Published: Jan. 31, 2025

Language: Английский

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Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 22, 2025

Abstract Despite known sex differences in human synucleinopathies such as Parkinson’s disease, the impact of on alpha-synuclein pathology mouse models has been largely overlooked. To address this need, we examine whole brain signatures neurodegeneration due to aSyn toxicity M83 model using longitudinal magnetic resonance imaging (MRI; T1-weighted; 100 μm 3 isotropic voxel; -7, 30, 90 and 120 days post-injection [dpi]; n ≥ 8 mice/group/sex/time point). initiate spreading, mice are inoculated with recombinant preformed fibrils (Hu-PFF) or phosphate buffered saline right striatum. We observe more aggressive neurodegenerative profiles over time for male Hu-PFF-injected when examining voxel-wise trajectories. However, at dpi, widespread patterns female mice. These not accompanied by any motor symptom onset between sexes. reached their humane endpoint sooner. findings suggest that post-motor onset, despite accelerated disease trajectories mice, may appear sooner (prior symptomatology). sex-specific synucleinopathy phenotypes urgently need be considered improve our understanding neuroprotective mechanisms.

Language: Английский

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Sex differences in age-associated neurological diseases—A roadmap for reliable and high-yield research

Science Advances, Journal Year: 2025, Volume and Issue: 11(10)

Published: March 5, 2025

Once taken into consideration, sex differences in neurological diseases emerge abundance: (i) Stroke severity is significantly higher females than males, (ii) Alzheimer's disease (AD) pathology more pronounced females, and (iii) conspicuous links with hormonal cycles led to female-specific diagnoses, such as catamenial migraines epilepsy. While these receive increasing attention isolation, they likely link similar processes the brain. Hence, this review aims present an overview of influences chromosomes, hormones, aging on male female brains across health disease, a particular focus AD stroke. The here advancements several fields holds promise fuel future research lead enriched understanding brain effective personalized neurologic care for all.

Language: Английский

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3-Monothiopomalidomide, a new immunomodulatory imide drug (IMiD), blunts inflammation and mitigates ischemic stroke in the rat

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract An overactive neuroinflammatory response is often evident in the elderly and a significant contributor to brain tissue damage following acute ischemic stroke. Such an inflammatory largely mediated by microglial cells peripheral blood mononuclear (PBMCs). Classical anti-inflammatory agents have not proved clinically effective mitigating impact of stroke but highlighted targets for new drug development, particular excessive proinflammatory cytokine release. The immunomodulatory imide (IMiD) class has shown potential reducing neuroinflammation switching phenotypic expression away from regenerative one. 3-Monothiopomalidomide (3-MP), IMiD, brain/plasma concentration ratio 0.5 0.6, oral bioavailability 38.5%, monophasic disappearance half-life 3.2 h administration. 3-MP pretreatment mitigates lipopolysaccharide (LPS)-induced inflammation cellular human PBMCs and, rat studies, lowers levels conditioned media plasma brain, respectively. Administered systemically rats challenged with middle cerebral artery occlusion (MCAo) reperfusion, post-MCAo treatment reduced infarction volume; improved body asymmetry, behavioral measure impact; lowered inflammation. In summary, exerted neuroprotective effects via actions against MCAo-induced injury represents therapeutic that warrants further investigation as related disorders associated

Language: Английский

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