Autoimmune Diseases and Molecular Mimicry in Tuberculosis DOI Creative Commons
Leonid P. Churilov, Muslimbek G. Normatov, Hong Ling

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1083 - 1083

Published: Dec. 22, 2024

Comorbidities in tuberculosis patients are increasing annually. Autoimmune pathology may influence the diagnosis and treatment of (TB). However, molecular mimicry between Mycobacterium (Mtb) human autoantigens is an important provocative factor development autoimmunity on one hand. Mtb has already been widely discussed as a provocateur humans. The aim this study was to determine whether exists antigens previously demonstrated targets autoimmunity. Materials Methods: We analyzed level antibodies 19 with pulmonary tuberculosis. In all cases ELISA assays used. Also, parallel, we identified 29 similar pentapeptides key autoantigens. Bioinformatic methods were used study. All amino acid sequences MT obtained from UniProt database, epitopes using original “Alignmentaj” program. immunoreactivity shared evaluated use IEDB database. Results: high modified citrulinated vimentin (anti-MCV) most frequently detected (57%) comparison other antibodies. Elevated levels C3 complement fragments (47%) rheumatoid factors (21%) absence any rheumatic or autoimmune diseases noteworthy. Several belong immunoreactive antigens. bioinformatic data correlated our earlier studies corresponding autoantibodies sera TB patients. Conclusion: Our findings cross-reactivity sequence similarity proteins provide support for role antigen TB-related

Language: Английский

Autoimmune Diseases and Molecular Mimicry in Tuberculosis DOI Creative Commons
Leonid P. Churilov, Muslimbek G. Normatov, Hong Ling

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1083 - 1083

Published: Dec. 22, 2024

Comorbidities in tuberculosis patients are increasing annually. Autoimmune pathology may influence the diagnosis and treatment of (TB). However, molecular mimicry between Mycobacterium (Mtb) human autoantigens is an important provocative factor development autoimmunity on one hand. Mtb has already been widely discussed as a provocateur humans. The aim this study was to determine whether exists antigens previously demonstrated targets autoimmunity. Materials Methods: We analyzed level antibodies 19 with pulmonary tuberculosis. In all cases ELISA assays used. Also, parallel, we identified 29 similar pentapeptides key autoantigens. Bioinformatic methods were used study. All amino acid sequences MT obtained from UniProt database, epitopes using original “Alignmentaj” program. immunoreactivity shared evaluated use IEDB database. Results: high modified citrulinated vimentin (anti-MCV) most frequently detected (57%) comparison other antibodies. Elevated levels C3 complement fragments (47%) rheumatoid factors (21%) absence any rheumatic or autoimmune diseases noteworthy. Several belong immunoreactive antigens. bioinformatic data correlated our earlier studies corresponding autoantibodies sera TB patients. Conclusion: Our findings cross-reactivity sequence similarity proteins provide support for role antigen TB-related

Language: Английский

Citations

0