Fluctuation analysis for particle-based stochastic reaction–diffusion models DOI
Madeleine R. Heldman, Samuel A. Isaacson, Jingwei Ma

et al.

Stochastic Processes and their Applications, Journal Year: 2023, Volume and Issue: 167, P. 104234 - 104234

Published: Oct. 17, 2023

Language: Английский

A multiscale radiation biophysical stochastic model describing the cell survival response at ultra-high dose rate under different oxygenations and radiation qualities DOI
Marco Battestini, Marta Missiaggia,

Sara Bolzoni

et al.

Radiotherapy and Oncology, Journal Year: 2025, Volume and Issue: unknown, P. 110895 - 110895

Published: April 1, 2025

Language: Английский

Citations

0
On the Emergence of the Deviation from a Poisson Law in Stochastic Mathematical Models for Radiation-Induced DNA Damage: A System Size Expansion DOI Creative Commons
Francesco Cordoni

Entropy, Journal Year: 2023, Volume and Issue: 25(9), P. 1322 - 1322

Published: Sept. 11, 2023

In this paper, we study the system size expansion of a stochastic model for radiation-induced DNA damage kinetics and repair. particular, characterize both macroscopic deterministic limit fluctuation around it. We further show that such fluctuations are Gaussian-distributed. deriving results, provide insights into relationship between mathematical models Specifically, demonstrate how governing equations commonly employed in field arise naturally within framework as limit. Additionally, by examining limit, uncover deviations from Poissonian behavior driven interactions clustering among damages. Although behaviors have been empirically observed, our derived results represent first rigorous derivation incorporates these distribution model, eliminating need specific ad hoc corrections.

Language: Английский

Citations

5
Across the stages: a multiscale extension of the generalized stochastic microdosimetric model (MS-GSM2) to include the ultra-high dose rate DOI Creative Commons
Marco Battestini, Marta Missiaggia, A. Attili

et al.

Frontiers in Physics, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 8, 2023

Ultra-high dose rate (UHDR) irradiations with different types of radiation have shown a larger sparing normal tissue and unchanged tumor control respect to conventional delivery. In recent years, there has been an accumulation experimental evidence related the so-called FLASH effect. However, underpinning mechanism remains, date, extremely debated largely unexplained, while involvement multiple scales damage suggested. Since it is believed that chemical environment plays crucial role in effect, this work aims develop multi-stage tool, multiscale generalized stochastic microdosimetric model (MS-GSM 2 ), can capture several possible effects on DNA at UHDR regime, such as reduction yield due organic radical recombination, fixation oxygenation, spatial temporal deposition effects, allowing us explore most candidate mechanisms for explaining The (GSM ) probabilistic describes time evolution cell nucleus using principles, accounting levels spatio-temporal stochasticity. particular, GSM radiation-induced formation kinetic repair case protracted irradiation without considering Poissonian assumption treat number damage. work, we extend , coupling fast reaction kinetics, described by system ordinary differential equations, additional level stochasticity, i.e., chemistry. We simulate energy particles microscopic volume, which mimics nucleus, order examine combined species assume modifies peroxyl concentration, consequent indirect This emerges only more pronounced high doses. Moreover, depends quality. show MS-GSM describe empirical trend dose- rate-dependent sensitivity over broad range, particularly healthy occurring regime. complete generality also allows study impact delivery structures qualities, including LET beams.

Language: Английский

Citations

4
Validation of the generalized stochastic microdosimetric model (GSM2) over a broad range of LET and particle beam type: a unique model for accurate description of (therapy relevant) radiation qualities DOI Creative Commons

Giulio Bordieri,

Marta Missiaggia, Giorgio Cartechini

et al.

Physics in Medicine and Biology, Journal Year: 2024, Volume and Issue: 70(1), P. 015005 - 015005

Published: Dec. 11, 2024

. The present work shows the first extensive validation of

Language: Английский

Citations

1
On the radiation quality characterization in radiation therapy: from linear energy transfer to experimental microdosimetry DOI Creative Commons
Marta Missiaggia

The European Physical Journal Plus, Journal Year: 2024, Volume and Issue: 139(7)

Published: July 17, 2024

Abstract Radiation-induced biological damage is primarily characterized by the average dose absorbed tissue. Nevertheless, it acknowledged that other parameters, collectively constituting ”radiation quality,” play a crucial role in this context. However, defining and characterizing radiation quality radiotherapy to assess radiobiological remains an open challenge. The most commonly used approach quantify quality, Linear Energy Transfer (LET), reveals many flaws its applications. Microdosimetry represents alternative has been developed last decades considered more accurate description of quality. Both approaches are explored, each with inherent limitations promising potential.

Language: Английский

Citations

1
Fluctuation analysis for particle-based stochastic reaction–diffusion models DOI
Madeleine R. Heldman, Samuel A. Isaacson, Jingwei Ma

et al.

Stochastic Processes and their Applications, Journal Year: 2023, Volume and Issue: 167, P. 104234 - 104234

Published: Oct. 17, 2023

Language: Английский

Citations

2