Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core–Shell Nanofibers for Sustained Release

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9524 - 9524

Published: Sept. 1, 2024

Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber

Language: Английский

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Uniaxial Electrospinning Encapsulation of Bioactive Peptides into Green Nanofibers Containing Pullulan-Alginate-CaCl2

International Journal of Peptide Research and Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Jan. 6, 2025

Language: Английский

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Traceability, authentication, and quality control of food-grade lavender essential oil: A comprehensive review

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103466 - 103466

Published: March 3, 2025

Language: Английский

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Cinnamaldehyde/cinnamon essential oil loaded poly-L-lactic acid/ hydroxyapatite fibrous scaffolds as osteogenic differentiation enhancing system for bone tissue engineering applications

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

In this study, we developed electrospun poly-L-lactic acid (PLLA)/ hydroxyapatite (HA) fibers loaded with Cinnamaldehyde (Cin) or Cinnamon essential oil (E.O) as a dual-function system to modulate bone remodeling. Cin E.O natural component inhibited the resorption same formation process. The were characterized by SEM, FTIR, contact angle, and tensile test. biocompatibility of scaffolds was evaluated an MTT assessment. Additionally, osteogenic potency investigated alkaline phosphatase (ALP) activity assay, Alizarin Red staining, calcium content RT-PCR analysis. cinnamon compounds release profile studied over 12 days. results demonstrated that PLLA/HA/Cin PLLA/HA/E.O. had bead-free, randomly oriented morphologies suitable physicochemical properties for cell seeding survival.The level deposition ALP PLLA/HA/E.O significantly increased compared control group. Osteogenic-related gene expression including ALP, Runx2, osteocalcin, osteonectin significantlyupregulated in fiber revealed desirable differentiation can be appropriate canfidate tissue engineering applications.

Language: Английский

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PLA- and PHA-Biopolyester-Based Electrospun Materials: Development, Legislation, and Food Packaging Applications

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5452 - 5452

Published: Nov. 19, 2024

The high accumulation of plastic waste in the environment has led to great interest biodegradable polymers, such as polylactic acid (PLA) or polyhydroxyalkanoates (PHAs). Their benefits, combined with application electrospinning technology, represent an innovative proposal for food packaging industry. This article provides a comprehensive review latest developments PLA- and PHA-biopolyester-based electrospun materials applications, summarizing reported technologies, material properties, invention patents. In addition, legislation used assess their biodegradability is also detailed. Electrospun are largely developed through uniaxial, coaxial, emulsion, multiaxial, needleless techniques. can be obtained single multilayer structures, incorporation natural extracts, organic compounds, nanoparticles become strategy designing active systems. mainly been evaluated soil, compost, aquatic systems ASTM ISO normatives. this review, dependence biodegradation process on polymer type, conditions, test methods clearly reviewed. Moreover, these have shown excellent antioxidant antimicrobial resulting method extending shelf life fruits, bread, fish, meat products.

Language: Английский

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Formulation, E-Beam Crosslinking, and Comprehensive Characterisation of Lavender Oil-Enriched Hydrogels

Polymers, Journal Year: 2024, Volume and Issue: 16(22), P. 3150 - 3150

Published: Nov. 12, 2024

This study focused on the formulation, electron beam (e-beam) crosslinking, and characterisation of hydrogels enriched with lavender oil (LO) to enhance their structural functional properties for biomedical applications. Stable were synthesised using water-soluble polymers suitable ratios Tween 80 Isopropyl alcohol (IPA) as surfactant co-surfactant, respectively, via e-beam irradiation at doses up 70 kGy. The most effective crosslinking was achieved a radiation dose 30 kGy, depending concentrations surfactants LO. LO-enriched exhibited enhanced superabsorbent swelling (7700% 18,000%) faster equilibrium rates than control hydrogel. Structural analysis revealed flexible spongiform porous architecture larger mesh sizes (156 nm 246 nm) adequate elastic moduli (130 308 Pa). Degradation tests aligned data, demonstrating degradation rate 12% after 35 days, indicating an appropriate balance stability degradation. These findings suggest that technology, in conjunction LO addition, can effectively tailor hydrogel applications, making them promising candidates further research wound care, drug delivery systems, other biological

Language: Английский

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Peppermint extract-compound nanofiber production and characterization

International Journal of Clothing Science and Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Purpose As a result of referee evaluation, the subject scope article has been expanded. Previously, only polycaprolactone (PCL) loaded with peppermint extract had studied. peer review, nanostructure production was made peppermint-loaded polylactic acid (PLA). Literature information about PLA polymer added to Introduction section. Additionally, analyze presence in Fourier transform infrared (FTIR) measurements, comparison 100% PCL, and extract. In order observe effect type, evaluations were between produced nanostructures containing two different polymers. Mechanical, structural morphological properties measured. The main purpose study is evaluate on Design/methodology/approach Nanofiber structures by electrospinning process due their attractive such as low cost, flexibility, integrability high efficiency. parameters nanofiber structure process, mechanical fiber morphologies scanning electron microscope (SEM) characterization FTIR measurement analyzed, its potential possible usage areas interpreted. Findings this study, PCL polymers, which are various biodegradable biocompatible polymeric materials, successfully achieved. studies carried out, positive easy accessibility, sustainability produced. When compared, it observed that provided better properties, higher strength, thinner fibers' diameter smooth homogeneous surface, compared core PLA. It more advantageous obtaining nanofibers under same environmental conditions parameters. addition caused an approximately 25% loss strength PCL. 90% This situation associated regular arrangement conclusion, incorporating into fabrication offers several benefits, including enhanced antimicrobial bioactive effects. Originality/value uniform suitable-for-use partially beaded surface obtained method using Morphological evaluation SEM images structure, determined analysis. analysis, decrease elongation at break tensile values mint extract, but did not prevent use structure.

Language: Английский

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Design and Characterization of Polyvinyl Alcohol/Kappa‐Carrageenan Pickering Emulsion Biocomposite Films for Potential Wound Care Applications

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 113(1)

Published: Dec. 25, 2024

ABSTRACT This study aimed to develop polyvinyl alcohol (PVA) and kappa‐carrageenan (κCA) biocomposite films using a Pickering emulsion technique for wound care applications. Juniper essential oil modified sepiolite were incorporated enhance functionality, with prepared via solvent casting characterized structural, thermal, mechanical properties. The PCOS‐2 film exhibited the highest performance, Young's modulus of 6.25 ± 1.3 MPa, tensile strength 5.65 1.7 elongation at break 608.96% 72.8%. Antibacterial assays showed inhibition zones 9 10 mm against Staphylococcus aureus Escherichia coli , respectively, film, while antioxidant activity reached 63% DPPH radical scavenging after 12 h. Additionally, porosity hydrophilicity enhanced, as indicated by contact angles 55° control 71.2° PCOS‐2. These results underscore potential PVA/κCA sustainable bioactive dressings, combining resilience, bioactivity, environmental compatibility, future efforts focused on optimizing antibacterial efficacy gram‐negative bacteria clinical validation.

Language: Английский

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Recent progress in the source, extraction, activity mechanism and encapsulation of bioactive essential oils

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Dec. 25, 2024

There is growing concern about the potential risks posed by synthetic additives in industrial products, such as foods, cosmetics, agrochemicals, and personal care products. Many plant-derived essential oils (EOs) have been shown to exhibit excellent antibacterial, antifungal, antiviral, antioxidant activities, may therefore be used natural preservatives these applications. However, most EOs relatively low water solubility are prone chemical degradation during storage. The products of can toxic not able fully exert their biological activity, which limits application. Typically, challenges overcome encapsulating oil an appropriate colloid delivery system. This article begins reviewing sources, extraction, activity mechanisms EOs, then highlights plant-based encapsulation technologies that enhance efficacy. Finally, applications plant system discussed.

Language: Английский

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