Functionalised Sodium–Carboxymethylcellulose–Collagen Bioactive Bilayer as an Acellular Skin Substitute for Future Use in Diabetic Wound Management: The Evaluation of Physicochemical, Cell Viability, and Antibacterial Effects

Polymers, Journal Year: 2024, Volume and Issue: 16(16), P. 2252 - 2252

Published: Aug. 8, 2024

The wound healing mechanism is dynamic and well-orchestrated; yet, it a complicated process. hallmark of to promote regeneration in less time without invading skin pathogens at the injury site. This study developed sodium–carboxymethylcellulose (Na-CMC) bilayer scaffold that was later integrated with silver nanoparticles/graphene quantum dot nanoparticles (AgNPs/GQDs) as an acellular substitute for future use diabetic wounds. prepared by layering Na-CMC gauze onto ovine tendon collagen type 1 (OTC-1). post-crosslinked 0.1% (w/v) genipin (GNP) natural crosslinking agent. physical chemical characteristics were evaluated. results demonstrate crosslinked (CL) groups exhibited high-water absorption capacity (>1000%) ideal water vapour evaporation rate (2000 g/m2 h) lower biodegradation good hydrophilicity, compression, resilience, porosity than non-crosslinked (NC) groups. minimum inhibitory concentration (MIC) AgNPs/GQDs presented some bactericidal effects against Gram-positive Gram-negative bacteria. cytotoxicity tests on scaffolds demonstrated cell viability human epidermal keratinocytes (HEKs) dermal fibroblasts (HDFs). Therefore, could be potential candidate care.

Language: Английский

Role of crosslinkers in advancing chitosan-based biocomposite scaffolds for bone tissue engineering: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137625 - 137625

Published: Nov. 14, 2024

Language: Английский