Association between antinuclear antibodies status and preterm birth in Japanese pregnant women: a prospective cohort study from Adjunct Study of the Japan Environment and Children’s Study DOI Creative Commons
Mami Fukushige, Xi Lu, Minoru Satoh

et al.

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 28, 2024

Antinuclear antibodies (ANA) are important biomarkers for the diagnosis of autoimmune diseases; however, general population also tests positive at a low frequency, especially in women. Although effects various diseases on pregnancy outcomes have been studied, association ANA with healthy individuals is unclear. Preterm birth (PTB), major cause neonatal death or long-term health problems, complex condition multifactorial etiology, and underlying mechanism remains The present Adjunct Study aimed to determine between PTB pregnant Japanese women based data analysis Japan Environment Children's Study. In prospective cohort design, we analyzed demographic outcome 1085 who were recruited January 2011 March 2014 Kumamoto University target area. Demographic collected using self-administered questionnaires physician records. A serum titer ≥ 1:40 was defined as positive. Statistical performed by logistic regression objective variable. rate significantly higher those ANA-positive (adjusted odds ratio, 2.06; 95% confidence interval, 1.09–3.87) than not. This study suggests that positivity first trimester associated an increased risk PTB.

Language: Английский

Sex-specific and regional differences in the prevalence of diagnosed autoimmune diseases in Germany, 2022 DOI Creative Commons
Manas K. Akmatov, Claudia Kohring, Frank Peßler

et al.

Research in Health Services & Regions, Journal Year: 2025, Volume and Issue: 4(1)

Published: March 26, 2025

Research on the epidemiology of autoimmune diseases is impeded due to rarity most diseases. We aimed assess prevalence diagnosed in Germany and examine their sex-specific regional differences. A cross-sectional study using nationwide ambulatory claims data females males any age with statutory health insurance from 2022 was designed (N = 73,241,305). Autoimmune were identified by diagnostic codes International Classification Diseases Related Health Problems, 10th Revision, German Modification (ICD-10-GM). Regional differences examined at level urban rural districts 401). To control for demographic across we applied direct standardization method calculate sex- age-standardized prevalences population used as a standard population. Furthermore, calculated ratios (PR) 99% confidence intervals (99% CI) sex Of 73,241,305 insurees (median age, 45; interquartile range, 26-63 years), 6,307,120 had least one (any) disease 2022, corresponding crude 8.61% CI: 8.60-8.62%). all individuals diseases, 67% females. The single varied between 0.008% (pemphigus) 2.3% (autoimmune thyroiditis). Other high psoriasis (1.9%), rheumatoid arthritis (1.4%), type 1 diabetes (0.75%). higher than 25 31 highest PR observed thyroiditis (PR 5.92; 5.88-5.95), primary biliary cirrhosis (5.60; 5.36-5.84) systemic lupus erythematosus (5.15; 4.97-5.36). Males more likely be (1.37; 1.36-1.39), ankylosing spondylitis (1.40; 1.39-1.43) Guillain-Barré syndrome (1.31; 1.27-1.37). only without difference myasthenia gravis (1.00; 0.97-1.03). At district age- sex-standardized differed factor nearly 2 5.91% 11.62%. In general, East (former GDR) West FRG) Germany. Although rare, when considered whole, turned out common previously assumed, 12 affected

Language: Английский

Citations

0
Sex Differences in the Regulation of Interleukins in Chronic Pain: A Widely Recognized but Difficult-to-Tackle Factor DOI Open Access
Jie Liu, Zheng Li, Jie Ju

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3835 - 3835

Published: April 18, 2025

Chronic pain is an extremely prevalent healthcare issue that has a profound impact on individuals and society. Sex sex hormones regulate the threshold differently in males females processing. However, regulatory mechanisms of differences response to painful stimuli are still unclear, which contributes difficulty analgesic drug development. Interleukins mediate neuroinflammation involved development chronic pain. Recent studies have found regulation thresholds by interleukins. Most previous used male animals study effects treatments due complexity estrogen. This review summarizes only female or both sexes examine interleukin-regulated pain, provide theoretical basis for more targeted precision medicines

Language: Английский

Citations

0
Exploring complex links: inflammatory rheumatic diseases and men's health DOI
Burhan Fatih Koçyiğit, Yuliya Fedorchenko, Kassymkhan Sultanbekov

et al.

Rheumatology International, Journal Year: 2024, Volume and Issue: 44(5), P. 757 - 764

Published: March 15, 2024

Language: Английский

Citations

2
Giant cell arteritis: insights from a monocentric retrospective cohort study DOI
Fatima Alnaimat,

Hamza Alduradi,

Soud Al-Qasem

et al.

Rheumatology International, Journal Year: 2024, Volume and Issue: 44(6), P. 1013 - 1023

Published: March 19, 2024

Language: Английский

Citations

2
Epidemiology of SLE in Italy: an observational study using a primary care database DOI Creative Commons
Pietro Ferrara, Ippazio Cosimo Antonazzo, Manuel Zamparini

et al.

Lupus Science & Medicine, Journal Year: 2024, Volume and Issue: 11(1), P. e001162 - e001162

Published: May 1, 2024

Objectives To estimate the incidence and prevalence of SLE in Italy, to describe demographic clinical characteristics patients with newly diagnosed SLE. Methods A retrospective cohort study was conducted using The Health Improvement Network general practice database encompassing data from 634 753 people. cases were identified over period 2017–2022, employing three alternative definitions provide a more detailed understanding characteristics. Incidence rates expressed as per 100 000 person-years Demographic incident also studied. Results From 2017 2022, total 191 1385 prevalent under our first definition. In rate 6.51 (95% CI 6.29 6.74) person-years, 60.57 59.89 61.25) people, being five times higher women compared men. Both estimates have trended upwards since 2017. geographical variation across country seen. described, while potential associations some pre-existing conditions observed, such chronic kidney disease, hepatic rheumatoid arthritis Sjogren’s syndrome. Conclusions results this nationwide study, showed that has increased Italy recent years. Age, sex, area residence strongly correlate epidemiology condition.

Language: Английский

Citations

2
Association between antinuclear antibodies status and preterm birth in Japanese pregnant women: a prospective cohort study from Adjunct Study of the Japan Environment and Children’s Study DOI Creative Commons
Mami Fukushige, Xi Lu, Minoru Satoh

et al.

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 28, 2024

Antinuclear antibodies (ANA) are important biomarkers for the diagnosis of autoimmune diseases; however, general population also tests positive at a low frequency, especially in women. Although effects various diseases on pregnancy outcomes have been studied, association ANA with healthy individuals is unclear. Preterm birth (PTB), major cause neonatal death or long-term health problems, complex condition multifactorial etiology, and underlying mechanism remains The present Adjunct Study aimed to determine between PTB pregnant Japanese women based data analysis Japan Environment Children's Study. In prospective cohort design, we analyzed demographic outcome 1085 who were recruited January 2011 March 2014 Kumamoto University target area. Demographic collected using self-administered questionnaires physician records. A serum titer ≥ 1:40 was defined as positive. Statistical performed by logistic regression objective variable. rate significantly higher those ANA-positive (adjusted odds ratio, 2.06; 95% confidence interval, 1.09–3.87) than not. This study suggests that positivity first trimester associated an increased risk PTB.

Language: Английский

Citations

0