Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 812 - 812
Published: Oct. 11, 2024
To demonstrate causation or/and assess pathogenic mechanisms of environment-induced autoimmunity, various animal models that mimic the characteristics human autoimmune diseases need to be developed. Experimental studies in mice reveal genetic factors contribute diseases. Here, immune response two mouse strains congenic for non-H-2 genes, A.TL (H-2
Language: Английский
Rheumatology International, Journal Year: 2025, Volume and Issue: 45(1)
Published: Jan. 15, 2025
Language: Английский
Citations
1
The Egyptian Rheumatologist, Journal Year: 2025, Volume and Issue: 47(2), P. 65 - 69
Published: Jan. 17, 2025
Language: Английский
Citations
1
Seminars in Arthritis and Rheumatism, Journal Year: 2025, Volume and Issue: unknown, P. 152724 - 152724
Published: April 1, 2025
Language: Английский
Citations
0
Rheumatology International, Journal Year: 2024, Volume and Issue: 44(9), P. 1701 - 1713
Published: June 8, 2024
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with variable clinical manifestation, potentially leading to death. Importantly, patients SLE have an increased risk of neoplastic disorders. Thus, this study aimed comprehensively evaluate the and laboratory characteristics or without malignancy.
Language: Английский
Citations
3
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4486 - 4486
Published: July 31, 2024
Background: Lupus nephritis (LN) is an inflammation of the kidneys that related to systemic lupus erythematosus (SLE). This study aimed evaluate differences in clinical and laboratory characteristics between LN non-LN SLE patients. Methods: We conducted a retrospective analysis medical records collected from patients treated at University Hospital Kraków, Poland, 2012 2022. All met 2019 European League Against Rheumatism American College Rheumatology (EULAR/ACR) criteria for SLE. Results: Among 921 patients, was documented 331 (35.94%). were younger diagnosis (29 vs. 37 years; p < 0.001) had male proportion 2.09 times higher than group (16.62% 7.97%; 0.001). They more often diagnosed with serositis hematological or neurological involvement (p 0.001 all). Hypertension hypercholesterolemia occurred frequently these both). exhibited frequency anti-dsDNA, anti-histone, anti-nucleosome antibodies Conversely, 1.24-fold (95% CI: 1.03–1.50; = 0.021) increase odds ratio having positive anti-cardiolipin IgM antibody results. immunosuppressants. The risk factors experiencing least three flares included female sex, age onset SLE, occurring later onset, presence anti-dsDNA antibodies, certain manifestations such as myalgia, arthritis, proteinuria > 3.5 g/day, pathological urinary casts urine sediment. Conclusions: differ diagnosis, treatment modalities, autoantibody profile have frequent, severe However, we still need prospective studies understand diversity its progression
Language: Английский
Citations
3
Reumatologia/Rheumatology, Journal Year: 2024, Volume and Issue: 62(2), P. 83 - 93
Published: May 10, 2024
Introduction The aims were to study the sociodemographic characteristics of patients presenting clinic and clinical serological pattern systemic lupus erythematosus (SLE) in a new rheumatology predominantly Yoruba population. Material methods This was retrospective, cross-sectional conducted over 7 years (January 2017 – December 2023). Patients who satisfied 1997 American College Rheumatology (ACR) and/or 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria enrolled using their medical records. with overlap syndromes other inflammatory or noninflammatory rheumatic diseases excluded from study. Their sociodemographic, clinical, laboratory, treatment data retrieved records analysed IBM SPSS version 23.0 software. Results A total 65 diagnosed SLE frequency 15.8%. mean age ±SD at presentation 33.85 ±11.01 female male ratio 9.8 : 1. median (IQR) duration symptoms 7.0 months (3–24). common presentations included synovitis (86.2%), acute cutaneous rash (53.8%), oral ulcers (52.3%), nonscarring alopecia (50.8%), serositis (47.7%). Proteinuria seen 37.7% predominant renal histopathological feature Class IV. Antinuclear antibody 100% positive 50.94% having titre 1 5,120 above. Anti- double-stranded deoxyribonucleic acid anti-Smith antibodies each had 50% prevalence. Dyslipidaemia found 76.7% patients. Conclusions study’s findings are largely consistent similar studies done Africa. Further prospective multi-centred needed further determine epidemiological disease Nigeria multi-ethnic
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Dec. 17, 2024
Abstract Lupus nephritis (LN) is a serious problem that results from systemic lupus erythematosus (SLE) complications. Recent studies have highlighted non-coding RNA (ncRNA) dysregulation notable feature in patients with SLE. As result, this research was designed to investigate lncRNA CASC2 and miR-155 levels as non-invasive diagnostic biomarkers SLE patients, including those without nephritis, their effectiveness assessing disease severity predicting LN. Our study included 60 who were subclassified into (30 non-LN 30 LN groups), along control subjects. Quantification of serum samples the Egyptian population carried out real-time polymerase chain reaction (RT-PCR). The activity index (SLEDAI) for evaluated, analysis receiver operating characteristic (ROC) curve implemented. Increased observed compared healthy controls, even higher group versus patients’ group. Conversely, noted be down-regulated relative its lower elevated expression reduced both correlated disease. current illustrated could act valuable among well abilities detect progression.
Language: Английский
Citations
1
Lupus, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
To summarize the causes of death and clinical characteristics systemic lupus erythematosus (SLE) hospitalized patients in last 20 years to improve SLE survival rates by detecting critical early.
Language: Английский
Citations
1
Quality in Sport, Journal Year: 2024, Volume and Issue: 18, P. 53423 - 53423
Published: Aug. 12, 2024
Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, often affecting women of childbearing age, with periods exacerbations and remissions. SLE can impact multiple organs, causing range clinical symptoms. Neuropsychiatric systemic (NPSLE) includes symptoms like headaches, seizures, anxiety disorders, cognitive dysfunctions, psychosis, neuropathies. Its diagnosis challenging, treatment complex. Purpose: This study aims to explain the pathophysiology NPSLE, describe diagnostic methods, summarize current methods based on recent research. Methods: Databases such as PubMed, Medline, ResearchGate were used. State knowledge: Early accurate crucial for optimal patient management. The 2019 EULAR/ACR classification criteria have improved precision weighted scoring system diverse disease manifestations. Therapy neuropsychiatric focuses symptom control causal treatment, considering anti-inflammatory action or counteracting ischemic incidents. It involves immunosuppressive agents antiplatelet anticoagulant substances. Non-pharmacological interventions lifestyle modifications are also important. dynamic reflect ongoing advancements in understanding SLE, emphasizing continuous research collaboration. Conclusions: NPSLE requires excluding other causes symptoms, infections, endocrine drug reactions. Diagnostic vary including lumbar puncture, CSF analysis, EEG, function assessment, MRI. therapy individualized severity burden.
Language: Английский
Citations
0
Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 812 - 812
Published: Oct. 11, 2024
To demonstrate causation or/and assess pathogenic mechanisms of environment-induced autoimmunity, various animal models that mimic the characteristics human autoimmune diseases need to be developed. Experimental studies in mice reveal genetic factors contribute diseases. Here, immune response two mouse strains congenic for non-H-2 genes, A.TL (H-2
Language: Английский
Citations
0