The natural course of health-related quality of life in patients with clinically suspect arthralgia: a longitudinal study in progressors and non-progressors to rheumatoid arthritis DOI Creative Commons
Sterre Bour, Lucas Goossens, Sarah J H Khidir

et al.

Rheumatology International, Journal Year: 2025, Volume and Issue: 45(5)

Published: April 19, 2025

Abstract Individuals with clinically suspect arthralgia (CSA) are at risk of developing rheumatoid arthritis (RA). It is unknown whether CSA patients have a deprived health-related quality-of-life (HRQoL), how this develops over time, and it differs between those who develop RA do not. Using three unique cohorts, we explored the course HRQoL in after inflammatory (IA, case defined as being either undifferentiated (UA) or RA) diagnosis. Longitudinal cohort data were used from two cohorts ( n = 507) an IA 282). measured EuroQol-5 Dimensions-5 levels (EQ-5D-5 L) questionnaire was compared We estimated EQ-5D-5 L scores linear mixed models. In addition, autoantibody-positive -negative compared. As developed IA, their mean deteriorated 0.12 points (0.03–0.22) years, mobility usual activities most impacted. Self-care pain/discomfort already impacted longer before Treatment initiation diagnosis showcased improvement 0.13 (0.09–0.16) within 4 months, particularly self-care dimensions, stabilizing thereafter. did not remained stable minor 0.05 (0.02–0.08) 2 years. Autoantibody-status had no impact. deteriorates but improves treatment initiation. experience HRQoL. These findings suggest that early intervention could prevent deterioration HRQoL, supporting potential value phase.

Language: Английский

The natural course of health-related quality of life in patients with clinically suspect arthralgia: a longitudinal study in progressors and non-progressors to rheumatoid arthritis DOI Creative Commons
Sterre Bour, Lucas Goossens, Sarah J H Khidir

et al.

Rheumatology International, Journal Year: 2025, Volume and Issue: 45(5)

Published: April 19, 2025

Abstract Individuals with clinically suspect arthralgia (CSA) are at risk of developing rheumatoid arthritis (RA). It is unknown whether CSA patients have a deprived health-related quality-of-life (HRQoL), how this develops over time, and it differs between those who develop RA do not. Using three unique cohorts, we explored the course HRQoL in after inflammatory (IA, case defined as being either undifferentiated (UA) or RA) diagnosis. Longitudinal cohort data were used from two cohorts ( n = 507) an IA 282). measured EuroQol-5 Dimensions-5 levels (EQ-5D-5 L) questionnaire was compared We estimated EQ-5D-5 L scores linear mixed models. In addition, autoantibody-positive -negative compared. As developed IA, their mean deteriorated 0.12 points (0.03–0.22) years, mobility usual activities most impacted. Self-care pain/discomfort already impacted longer before Treatment initiation diagnosis showcased improvement 0.13 (0.09–0.16) within 4 months, particularly self-care dimensions, stabilizing thereafter. did not remained stable minor 0.05 (0.02–0.08) 2 years. Autoantibody-status had no impact. deteriorates but improves treatment initiation. experience HRQoL. These findings suggest that early intervention could prevent deterioration HRQoL, supporting potential value phase.

Language: Английский

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