Reliability and validity of measuring temporal muscle thickness as the evaluation of sarcopenia risk and the relationship with functional outcome in older patients with acute stroke

Clinical Neurology and Neurosurgery, Journal Year: 2021, Volume and Issue: 201, P. 106444 - 106444

Published: Jan. 1, 2021

Language: Английский

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Temporal Muscle and Stroke—A Narrative Review on Current Meaning and Clinical Applications of Temporal Muscle Thickness, Area, and Volume

Nutrients, Journal Year: 2022, Volume and Issue: 14(3), P. 687 - 687

Published: Feb. 6, 2022

Evaluating muscle mass and function among stroke patients is important. However, evaluating volume not easy due to the disturbances of consciousness paresis. Temporal thickness (TMT) has been introduced as a novel surrogate marker for mass, function, nutritional status. We herein performed narrative literature review on temporal understand current meaning TMT in clinical practice.

Language: Английский

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Evaluation of the Temporal Muscle Thickness as an Independent Prognostic Biomarker in Patients with Primary Central Nervous System Lymphoma

Cancers, Journal Year: 2021, Volume and Issue: 13(3), P. 566 - 566

Published: Feb. 2, 2021

In this study, we assessed the prognostic relevance of temporal muscle thickness (TMT), likely reflecting patient’s frailty, in patients with primary central nervous system lymphoma (PCNSL). 128 newly diagnosed PCNSL TMT was analyzed on cranial magnetic resonance images. Predefined sex-specific cutoff values were used to categorize patient cohort. Survival analyses, using a log-rank test as well Cox models adjusted for further parameters, performed. The risk death significantly increased reduced (hazard ratio 3.189, 95% CI: 2–097–4.848, p < 0.001). Importantly, results confirmed that could be an independent marker upon multivariate modeling 2.504, 1.608–3.911, 0.001) adjusting sex, age at time diagnosis, deep brain involvement lesions, Eastern Cooperative Oncology Group (ECOG) performance status, and methotrexate-based chemotherapy. A value below sex-related diagnosis is adverse PCNSL. Thus, our suggest systematic inclusion translational clinical studies designed help validate its role biomarker.

Language: Английский

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Effect of sarcopenia and frailty on outcomes among patients with brain metastases

Journal of Neuro-Oncology, Journal Year: 2024, Volume and Issue: 167(1), P. 169 - 180

Published: March 1, 2024

Language: Английский

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Age- and sex-adjusted CT-based reference values for temporal muscle thickness, cross-sectional area and radiodensity

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 18, 2025

Muscle mass has been traditionally assessed by measuring paraspinal muscle areas at the level of third lumbar vertebra on computed tomography (CT). Neurological or neurosurgical patients seldom undergo CT scans region. Instead, temporal thickness (TMT), cross-sectional area (TMA) and radiodensity measured from head are readily available measures quality in these patient cohorts. The purpose this retrospective study was to establish CT-based reference values for TMT, TMA each decade age 0 100 years normalized sex, define cut-off subjects risk sarcopenia as defined European Working Group Sarcopenia Older People (EWGSOP). Subjects diagnosed with a concussion Oulu University Hospital between January 2014 December 2022 (n = 9254) were identified obtain population. significant pre-existing co-morbidities excluded. measured, measurement reliability quantified, sex-adjusted calculated decade. Quantile regression used model age-related changes morphomics. A total 500 [250 (50.0%) males] mean 49.2 ± 27.9 evaluated. Inter- intra-observer almost perfect TMT TMA, substantial-to-almost radiodensity. 5.2 1.9 mm, 284 159 mm2 44.6 17.7HU, respectively. reduced males/females using compliant criteria ≤ 4.09 mm/≤3.44 166 mm2/≤156 mm2, 35.5HU/≤35.2HU, We described standardized protocol practical clinical use reliability. Using protocol, we produced quantile models detection lowest 5th, 10th, 20th, 30th, 40th 50th percentiles well EWGSOP facilitate generalizable radiological research.

Language: Английский

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Predictive value of temporal muscle thickness for prognosis in newly diagnosed IDH wild-type glioblastoma patients: evaluated for a Chinese population

European Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

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Development and Validation of an Early Recurrence Prediction Model for High-Grade Glioma Integrating Temporalis Muscle and Tumor Features: Exploring the Prognostic Value of Temporalis Muscle

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

This study aimed to develop and validate a predictive model for early recurrence of high-grade glioma (HGG) within 180 days, assess the prognostic value preoperative postoperative temporalis muscle metrics (area thickness), explore their significance in follow-up. Seventy-one molecularly confirmed HGG patients were included, with data sourced from local TCIA (The Cancer Imaging Archive) RHUH-GBM (Río Hortega University Hospital Glioblastoma) dataset. Tumor segmentation was performed using deep learning, radiomic features extracted following comparison manual segmentation. Feature selection conducted mutual information recursive feature elimination. A comprehensive integrating 3D tumor radiomics developed compared tumor-only identify optimal framework. SHAP analysis used evaluate interpretability importance. The TM_Tumor_HistGradientBoosting model, incorporating 16 including metrics, outperformed accuracy (0.89), recall (0.87), F1 score (0.88). highlighted that cross-sectional area strongly associated risk, while thickness significantly contributed prediction. Combining MRI substantially improved prediction HGG. Temporalis serve as objective sustainable indicators significant clinical

Language: Английский

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Comprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2025, Volume and Issue: 16(2)

Published: April 1, 2025

ABSTRACT Background Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Patients with GBM are particularly susceptible to moderate‐to‐high frail. Frailty status has been associated outcome of many types cancer, including GBM, although there still little consensus regarding specific criteria for assessing frailty status. This study aimed determine predictive significance modified score (mFS) patients using haematological and sarcopenia indicators. Methods Between January 2016 September 2022, we enrolled 309 adult patients. Data on demographics, examination, temporal muscle thickness (TMT) were collected assessed. The prognostic relevance parameters was established Kaplan–Meier Cox proportional model. scoring systems created by integrating these Variables independent values used construct nomograms. Nomogram accuracy evaluated calibration curve, Harrell's concordance index (C‐index), time‐dependent receiver operating characteristic curves. Clinical practicality assessed decision curve analysis. Results baseline characteristics participants revealed a median age 59 years (interquartile range 52–66) predominance male (58.58%). TMT (hazard ratio [HR] = 3.787, 95% confidence interval [CI] 2.576–5.566, p < 0.001), nutritional (HR 1.722, CI 1.098–2.703, 0.018), mean corpuscular volume 1.958, 1.111–3.451, 0.020) identified as markers. constructed mFS, obtained three indices, exhibited 2.461, 1.751–3.457, 0.001). low‐risk group had overall survival (OS) 13.9 months, while high risk OS 5.8 months. Importantly, mFS demonstrated significant value subgroup aged > 65 1.822, 1.011–3.284, 0.046). nomogram, which included accuracy, c‐index 0.781. nomogram bootstrapped plot also performed well compared ideal Nomograms showed promising discriminative potential, areas under curves 0.945, 0.835, 0.820 0.5‐, 1‐, 2‐year prediction, respectively. Conclusions Preoperative comprehensive marker predicting outcomes GBM. A dynamic incorporating may facilitate preoperative evaluation. Early appropriate multimodal interventions, support, rehabilitation, psychological care, help neurosurgical care or other tumours.

Language: Английский

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Temporal Muscle Thickness as a Prognostic Marker in a Real‐Life Cohort of Newly Diagnosed MGMT Promoter Methylated Glioblastoma: A Multicentric Imaging Analysis

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(8)

Published: April 1, 2025

ABSTRACT Introduction Prior research has identified temporal muscle thickness (TMT) as a prognostic marker in glioblastoma. Nonetheless, implementation daily clinical practice is complicated due to the heterogeneity of previous studies. We performed multicentric analysis aiming validate recently proposed sex‐specific cutoff values using homogeneous cohort newly diagnosed MGMT promoter methylated glioblastoma patients; we included balanced control for comparison. Materials and Methods TMT was measured at baseline initial preoperative/postoperative magnetic resonance images (MRIs) disease course first MRI after radiotherapy. Patients were divided by sex into “at risk sarcopenia” or “normal status.” Kaplan–Meier multivariable Cox regression used survival correlation. Results In total, n = 126 patients ( 66 treated with CCNU/temozolomide, 60 single‐drug temozolomide). normal mass had significantly prolonged (median overall survival: 44.2 months versus 16.7 29.5 17.4 temozolomide) compared those sarcopenia. analysis, an age diagnosis < 50 years emerged significant markers. Longitudinally, longest lack decline over course. Discussion This confirms important two real‐life cohorts. However, order establish assessment routine patient selection therapeutic measures, further validation prospective controlled trials necessary.

Language: Английский

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Temporal muscle thickness as an independent prognostic imaging marker in newly diagnosed glioblastoma patients: A validation study

Neuro-Oncology Advances, Journal Year: 2022, Volume and Issue: 4(1)

Published: Jan. 1, 2022

Previous studies have recognized temporal muscle thickness (TMT) as a prognostic marker in glioblastoma, but clinical implementation is hampered due to studies' heterogeneity and lack of established cutoff values. The aim this study was assess the validity recent proposed sex-specific TMT values real-world population genotyped primary glioblastoma patients.We measured preoperative MR images 328 patients. Sex-specific were used divide patients into "at risk sarcopenia" or "normal status". Kaplan-Meier analyses stepwise multivariate Cox-Regression association with overall survival (OS) progression-free (PFS). occurrence complications discontinuation treatment investigated using odds ratios (OR).Patients at sarcopenia had significantly higher progression death than normal status, which remained significant (OS HR = 1.437; 95%CI: 1.046-1.973; P .025 PFS 1.453; 1.037-2.036; .030). Patients also early (OR 2.45; 1.011-5.952; .042) lower chance receiving second-line 0.23; 0.09-0.60; .001). There no complications.Our confirms external use an independent newly diagnosed This simple, noninvasive could improve patient counseling aid decision processes trial stratification.

Language: Английский

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