Lymphatic Research and Biology, Journal Year: 2023, Volume and Issue: 21(4), P. 410 - 429
Published: Aug. 1, 2023
Hypertension, Journal Year: 2024, Volume and Issue: 81(5), P. 991 - 1007
Published: March 1, 2024
Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to impairment on vascular bases, increasing evidence suggests potential association of hypertension with the neurodegenerative pathology underlying Alzheimer disease. Hypertension well known disrupt structural and functional integrity cerebral vasculature. However, mechanisms by which these alterations lead brain damage, enhance pathology, promote remain be established. Furthermore, critical questions concerning whether lowering antihypertensive medications prevents have not been answered. Recent developments in neurovascular biology, imaging, epidemiology, as new clinical trials, provided insights into issues. In particular, basic findings link between dysfunction pathobiology neurodegeneration shed light overlap pathology. this review, we will examine progress made relationship and, after evaluation evidence, attempt identify remaining knowledge gaps future research directions that may advance our understanding one leading health challenges time.
Language: Английский
Citations
30
Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)
Published: March 13, 2024
Abstract The discoveries that cerebrospinal fluid participates in metabolic perivascular exchange with the brain and further drains solutes to meningeal lymphatic vessels have sparked a tremendous interest translating these seminal findings from animals humans. A potential two-way coupling between extra-vascular compartment peripheral immune system has implications exceed those concerning neurodegenerative diseases, but also imply central nervous pushed its immunological borders toward periphery, where cross-talk mediated by may play role range of neoplastic diseases. Due non-invasive approach, magnetic resonance imaging typically been preferred methodology attempts image glymphatic lymphatics Even if flourishing, research field is still cradle, interpretations topographically associate reports yet seemed downplay presence previously described anatomical constituents, particularly dura. In this brief review, we illuminate challenges assess evidence for glymphatic-lymphatic coupling. Finally, provide new perspective on how human clearance function possibly be measured future.
Language: Английский
Citations
12
Neuroimaging Clinics of North America, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 3, 2025
Abstract The parasagittal dura (PSD) is a thin channel along the sagittal sinus vein at brain’s upper convexities. Previous studies have shown that cerebrospinal fluid (CSF) flows directly into PSD, with PSD dimensions and tracer clearance rates associated aging brain disorders. Since slow lymphatic drainage sensitive to water diffusion, circulation may be evaluated using diffusion-weighted imaging (DWI). However, traditional echo-planar DWI (EP-DWI) suffers from low resolution image distortion, limiting its application assessment. This study employed high-resolution Multiplexed Sensitivity Encoding (MUSE) Periodically Rotated Overlapping Parallel Lines Enhanced Reconstruction (PROPELLER) investigate diffusion. These advanced techniques reduce distortion while enhancing spatial resolution. Our results demonstrated structures are clearly visible on apparent diffusion coefficient (ADC) maps, correlating locations identified T2 FLAIR imaging. In addition, mean ADC values of (1843.1–2062.2 × 10 − 6 mm 2 /sec) were higher than those gray white matter but lower CSF. findings highlight potential MUSE PROPELLER for assessing offering promising non-invasive tool studying role in neurological
Language: Английский
Citations
0
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: May 4, 2025
Abstract In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated CNS diseases and conditions associated with dysfunction include neurodegenerative diseases, stroke, infections, traumatic brain injury, tumors, functional cranial disorders, hydrocephalus. However, the understanding of regulatory damage mechanisms lymphatics under physiological pathological is currently limited. Given importance profound interplay between this review covers seven key aspects: development structure vessels, methods for observing lymphatics, function molecular relationships vessels potential conclusions outstanding questions. We will explore relationship development, structure, current both animal models humans, identify unresolved points research. The aim to provide new directions future research therapeutic strategies targeting by critically analyzing advancements field, identifying gaps knowledge, proposing innovative approaches address these gaps.
Language: Английский
Citations
0
Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(12)
Published: Aug. 15, 2024
Abstract The glymphatic system (GS) is a whole‐brain perivascular network, consisting of three compartments: the periarterial and perivenous spaces interposed brain parenchyma. GS dysfunction has been implicated in neurodegenerative diseases, particularly Alzheimer's disease (AD). So far, comprehensive research on humans limited by absence easily accessible biomarkers. Recently, promising non‐invasive methods based magnetic resonance imaging (MRI) along with aquaporin‐4 (AQP4) quantification cerebrospinal fluid (CSF) were introduced for an indirect assessment each compartments. We recruited 111 consecutive subjects presenting symptoms suggestive degenerative cognitive decline, who underwent 3 T MRI scanning including multi‐shell diffusion‐weighted images. Forty nine out also CSF examination CSF‐AQP4. CSF‐AQP4 levels measures—including (PVS) counts volume fraction (PVSVF), white matter free water (FW‐WM) mean kurtosis (MK‐WM), diffusion tensor analysis (DTI‐ALPS) (mean, left right)—were compared among patients AD ( n = 47) other diseases (nAD 24), stable mild impairment (MCI 17) cognitively unimpaired (CU 23) elderly people. Two runs conducted, first all patients; second after dividing both nAD into two subgroups gray atrophy as proxy stage. Age, sex, years education, time included confounding factors analyses. Considering whole cohort, showed significantly higher (exp(b) 2.05, p .005) FW‐WM 1.06, .043) than CU. AQP4 respect to CU 2.98, < .001). less atrophic 2.20, .006; exp(b) 1.08, .019, respectively) 2.66, .002; 1.10, subjects. Higher total 1.59, .013) centrum semiovale PVS 1.89, .016), 1.50, .036) WM PVSVF together lower MK‐WM 0.94, .006), ALPS 0.91, .043; 0.88, .010 observed more In addition, exhibited 3.39, .002) Our results indicate significant changes putative biomarkers dementias, suggesting close interaction between neurodegeneration, case AD. However, usefulness some these standalone indices activity may be hindered their dependence stage structural damage.
Language: Английский
Citations
2
Acta Neurochirurgica, Journal Year: 2024, Volume and Issue: 166(1)
Published: June 21, 2024
Abstract The discovery of the glymphatic system has fundamentally altered our comprehension cerebrospinal fluid transport and removal waste from brain metabolism. In past decade, since its initial characterization, research on surged exponentially. Its potential implications for central nervous disorders have sparked significant interest in field neurosurgery. Nonetheless, ongoing discussions debates persist regarding concept system, current understanding largely relies findings experimental animal studies. This review aims to address several key inquiries: What methodologies exist evaluating function humans today? is evidence supporting existence a human system? Can be considered distinct meningeal-lymphatic glymphatic-meningeal lymphatic failure neurosurgical diseases? Existing literature indicates paucity techniques available assessing humans. Thus far, intrathecal contrast-enhanced magnetic resonance imaging (MRI) shown most promising results provided presence humans, albeit with limitations. It is, however, essential recognize interconnection between meningeal systems, as they operate tandem. There are some studies demonstrating deteriorations associated disorders, enriching their pathophysiology. However, translation this knowledge into clinical practice hindered by constraints modalities.
Language: Английский
Citations
1
Current Neurology and Neuroscience Reports, Journal Year: 2024, Volume and Issue: 24(10), P. 517 - 525
Published: Aug. 16, 2024
Language: Английский
Citations
1
Journal of Cancer Research and Therapeutics, Journal Year: 2024, Volume and Issue: 20(4), P. 1306 - 1313
Published: Aug. 1, 2024
The current study aimed to investigate the dynamic changes in brain glymphatic function during chemotherapy breast cancer patients (BCP) and their correlation with cognitive function.
Language: Английский
Citations
1
Phytomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 156041 - 156041
Published: Sept. 1, 2024
Language: Английский
Citations
1