Update August 2023 DOI
Francine Blei

Lymphatic Research and Biology, Journal Year: 2023, Volume and Issue: 21(4), P. 410 - 429

Published: Aug. 1, 2023

The role and mechanism of Aβ clearance dysfunction in the glymphatic system in Alzheimer’s disease comorbidity DOI Creative Commons

H L Li,

Qianqian Yao, Xueyan Huang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Alzheimer’s disease (AD) is the leading type of dementia globally, characterized by a complex pathogenesis that involves various comorbidities. An imbalance in production and clearance amyloid β-protein (Aβ) peptides brain key pathological mechanism AD, with glymphatic system playing crucial role Aβ clearance. Comorbidities associated such as diabetes, depression, hypertension, not only affect but also impair brain’s lymphatic system. Abnormalities structure function this further weaken capabilities, presence comorbidities may exacerbate process. This paper aims to review specific mechanisms impaired via context AD comorbidities, providing new insights for prevention treatment AD. Overall, damage primarily focuses on aquaporin-4 (AQP4) perivascular spaces (PVS), suggesting maintaining health help slow progression its Additionally, given ongoing controversies regarding system, revisits discusses principles characteristics current detection methods

Language: Английский

Citations

1
Is enhanced-MRI a way for non-invasive evaluation of the glymphatic-meningeal lymphatic system in patients with cerebral small vessel disease? What we currently know DOI
Irene Grazzini

European Radiology, Journal Year: 2023, Volume and Issue: 33(9), P. 6094 - 6095

Published: July 6, 2023

Language: Английский

Citations

1
Decreased DTI-ALPS index in delirium: a preliminary MRI study DOI
Ye Tu,

Ren‐Jie Song,

Fei Xiong

et al.

Neuroradiology, Journal Year: 2024, Volume and Issue: 66(10), P. 1729 - 1735

Published: July 9, 2024

Language: Английский

Citations

0
Comparative Study of 3D-T2WI vs. 3D-T2-FLAIR MRI in Displaying Human Meningeal Lymphatics Vessels DOI
Yan Fang, Yi Sun,

T Lai

et al.

Clinical Radiology, Journal Year: 2024, Volume and Issue: unknown, P. 106700 - 106700

Published: Sept. 1, 2024

Language: Английский

Citations

0
Update August 2023 DOI
Francine Blei

Lymphatic Research and Biology, Journal Year: 2023, Volume and Issue: 21(4), P. 410 - 429

Published: Aug. 1, 2023

Citations

0